Elevated Serum IgA and the Gut Microbiome in Children with Type 1 Diabetes (H-48824)

IgA is a defense protein that lines the gut and can be measured in blood. IgA changes how much and what types of bacteria are in the gut. The amount and type of bacteria (called microbiome) in the gut seem to change the likelihood that someone has diabetes. However, why and how this happens is not well known. With this study we hope to understand better if and how IgA and bacteria in the gut plays a role in developing type 1 diabetes. Knowing more about this can help us come up with new ways to prevent and treat type 1 diabetes. This is a prospective observational cohort study. 

Study goals: To compare serum IgA level, stool microbiome and clinical characteristics of children with T1D and healthy control siblings 

Eligibility criteria: Age 2-18 years diagnosed with type 1 diabetes within the last 6 months and their healthy siblings living in the same household.

Investigators: Maria Redondo M.D., Ph.D., MPH ( Principal Investigator)
Amruta Thakkar, M.D.
Joud Hajjar M.D., MS
Kristi Hoffman Ph.D., MPH
Juwan Cormier

Supported by: Baylor College of Medicine Research funds