Representative Papers
Yanagida, N., Ogawa, R., Li, Y., Lee, L.F. and Nazerian, K. Recombinant fowlpox viruses expressing the glycoprotein B homolog and the pp38 gene of Marek's disease virus. J Virol 66, 1402-1408 (1992). PMID: 1310754. PMC240863.
Li, Y. and Dodgson, J.B. The chicken HMG-17 gene is dispensable for cell growth in vitro. Mol Cell Biol 15, 5516-5523 (1995). PMID: 7565703. PMC230802.
Li, Y., Strahler, J.R. and Dodgson, J.B. Neither HMG-14a nor HMG-17 gene function is required for growth of chicken DT40 cells or maintenance of DNaseI-hypersensitive sites. Nucleic Acids Research 25, 283-288 (1997). PMID: 9016555. PMC146424.
Li, Y., Smith, T., Grabski, S. and DeWitt, D.L. The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes. J Biol Chem 273, 29830-29837 (1998). PMID: 9792699.
Fisher, G.H., Orsulic, S., Holland, E., Hively, W.P., Li, Y., Lewis, B.C., Williams, B.O. and Varmus, H.E. Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene 18, 5253-5260 (1999). PMID: 0010498877
Dunn, K.J., Williams, B.O., Li, Y. and Pavan, W.J. Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Proc Natl Acad Sci U S A 97, 10050-10055 (2000). PMID: 10963668. PMC34553.
Holland, E.C., Li, Y., Celestino, J., Dai, C., Schaefer, L., Sawaya, R.A. and Fuller, G.N. Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo. Am J Pathol 157, 1031-1037 (2000). PMID: 10980141. PMC1885688.
Li, Y., Hively, W.P. and Varmus, H.E. Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer. Oncogene 19, 1002-1009 (2000). PMID: 0010713683
Dunn, K.J., Incao, A., Watkins-Chow, D., Li, Y. and Pavan, W.J. In utero complementation of a neural crest-derived melanocyte defect using cell directed gene transfer. Genesis 30, 70-76 (2001). PMID: 11416866.
Li, Y., Podsypanina, K., Liu, X., Crane, A., Tan, L.K., Parsons, R. and Varmus, H.E. Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice. BMC: Mol Biol 2, 2 (2001). PMID: 11178110. PMC29091.
Orsulic, S., Li, Y., Soslow, R.A., Vitale-Cross, L.A., Gutkind, J.S. and Varmus, H.E. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell 1, 53-62 (2002). PMID: 12086888. PMC2267863.
Li, Y., Welm, B., Podsypanina, K., Huang, S., Chamorro, M., Zhang, X., Rowlands, T., Egeblad, M., Cowin, P., Werb, Z., Tan, L.K., Rosen, J.M. and Varmus, H.E. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci U S A 100, 15853-15858 (2003). PMID: 14668450. PMC307657.
Montaner, S., Sodhi, A., Molinolo, A., Bugge, T.H., Sawai, E.T., He, Y., Li, Y., Ray, P.E. and Gutkind, J.S. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell 3, 23-36 (2003). PMID: 12559173.
Podsypanina, K., Li, Y. and Varmus, H.E. Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype. BMC Med 2, 24 (2004). PMID: 15198801. PMC446228.
Sodhi, A., Montaner, S., Patel, V., Gomez-Roman, J.J., Li, Y., Sausville, E.A., Sawai, E.T. and Gutkind, J.S. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A 101, 4821-4826 (2004). PMID: 15047889. PMC387332.
Hu, X., Pandolfi, P.P., Li, Y., Koutcher, J.A., Rosenblum, M. and Holland, E.C. mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma. Neoplasia 7, 356-368 (2005). PMID: 15967113. PMC1501155.
Huang, S., Li, Y., Chen, Y., Podsypanina, K., Chamorro, M., Olshen, A.B., Desai, K.V., Tann, A., Petersen, D., Green, J.E. and Varmus, H.E. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biol 6, R84 (2005). PMID: 16207355. PMC1257467.
Zhang, X., Podsypanina, K., Huang, S., Mohsin, S.K., Chamness, G.C., Hatsell, S., Cowin, P., Schiff, R. and Li, Y. Estrogen receptor positivity in mammary tumors of Wnt-1 transgenic mice is influenced by collaborating oncogenic mutations. Oncogene 24, 4220-4231 (2005). PMID: 15824740.
Li, Y. and Rosen, J.M. Stem/progenitor cells in mouse mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 10, 17-24 (2005). PMID: 15886883
Grimm, S.L., Bu, W., Longley, M.A., Roop, D.R., Li, Y. and Rosen, J.M. Keratin 6 is not essential for mammary gland development. Breast Cancer Res 8, R29 (2006). PMID: 16790075. PMC1557733.
Huang, S., Podsypanina, K., Chen, Y., Cai, W., Tsimelzon, A., Hilsenbeck, S. and Li, Y. Wnt-1 is dominant over neu in specifying mammary tumor expression profiles. Technol Cancer Res Treat 5, 565-571 (2006). PMID: 17121432.
Lindvall, C., Evans, N.C., Zylstra, C.R., Li, Y., Alexander, C.M. and Williams, B.O. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem 281, 35081-35087 (2006). PMID: 16973609.
Du, Z., Podsypanina, K., Huang, H., McGrath, A., Toneff, M.J., Bogoslovskaia, E., Zhang, X., Moraes, R.C., Fluck, M.M., Allred, D.C., Lewis, M.T., Varmus, H.E. and Li, Y. Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc Natl Acad Sci U S A 103, 17396-17401 (2006). PMID: 17090666. PMC1635021.
Du, Z. and Li, Y. RCAS-TVA in the mammary gland: an in vivo oncogene screen and a high fidelity model for breast transformation? Cell Cycle 6, 823-826 (2007). PMID: 17377492
Lindvall, C., Bu, W., Williams, B.O. and Li, Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev 3, 157-168 (2007). PMID: 17873348.
Huang, S., Chen, Y., Podsypanina, K. and Li, Y. Comparison of expression profiles of metastatic versus primary mammary tumors in MMTV-Wnt-1 and MMTV-Neu transgenic mice. Neoplasia 10, 118-124 (2008). PMID: 18283333. PMC2244686.
Siwko, S., Bu, W., Gutierrez, C., Lewis, B.C., Jechlinger, M., Schaffhausen, B. and Li, Y. Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors. Neoplasia 10: 653-62 (2008). PMID: 18592025. PMC2435599.
Siwko, S., Dong, J., Lewis, M.T., Liu, H., Hilsenbeck, S.G., and Li, Y. Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells—implications for pregnancy-induced protection against breast cancer (Cover). Stem Cells 26:3205-9 (2008). PMID: 18787212. PMC2647777.
Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Molecular Cancer. 8;15 (2009). PMID: 19267898. PMC2669049.
Reddy, J.P. and Li, Y. The RCAS-TVA System for Introduction of Oncogenes into Selected Somatic Mammary Epithelial Cells in Vivo. J Mammary Gland Biol Neoplasia 14(4):405-9 (2009). PMID: 19936988.
Bu, W., Xin, L., Toneff, M., Li, L. and Li, Y. Lentivirus Vectors for Stably Introducing Genes into Mammary Epithelial Cells in Vivo. J Mammary Gland Biol Neoplasia 14(4):401-4 (2009). PMID: 19936990.
Reddy, J.P., Peddibhotla, S., Bu, W., Zhao, J., Haricharan, S., Du, Y.C., Podsypanina, K., Rosen, J.M., Donehower, L.A. and Li, Y. Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation. Proc Natl Acad Sci U S A. 107(8):3728-33 (2010). PMID: 20133707. PMC2840493.
Carpin LB, Bickford LR, Agollah G, Yu TK, Schiff R, Li Y, Drezek RA. Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells. Breast Cancer Res and Treatment. 125: 27-34 (2010). PMID20217215.
Toneff, M., Du, Z., Sinai, P., Forman, J., Huang, J., Hilsenbeck, S., Schiff, R., Huang, S. and Li, Y. Somatic activation of PyMT or ErbB2 induces estrogen-independent tumor initiation. Neoplasia. 12: 718-26 (2010). PMID: 20824048. PMC2933692.
Dong, J., Tong, T., Reynado, A.M., Rosen, J.M., Huang, S. and Li, Y. Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones. Dev Biol 345: 196-203 (2010). PMID: 20691178. PMC3020144.
T. Lin, L. Meng, Li, Y. and R. Y.L. Tsai. The Tumor-Initiating Function of Nucleostemin-Enriched Mammary Tumor Cells. Cancer Research. 70:9444-52. (2010). PMID: 21045149. PMC2982898.
Visbal, A.P., LaMarca, H.L., Villanueva, H., Toneff, M.J., Li, Y., Rosen, J.M. and Lewis, M.T. Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened. Dev Biol 352, 116-127 (2011). PMID: 21276786. PMC3057274.
Bu, W., Chen, J., Morrison, G.D., Huang, S., Creighton, C.J., Huang, J., Chamness, G.C., Hilsenbeck, S.G., Roop, D.R., Leavitt, A.D. and Li, Y. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. Oncogene 30, 4399-4409 (2011). PMID: 21532625. PMC3156856
Dong, J., Huang, S., Caikovski, M., Ji, S., McGrath, A., Custorio, M.G., Creighton, C.J., Maliakkal, P., Bogoslovskaia, E., Du, Z., Zhang, X., Lewis, M.T., Sablitzky, F., Brisken, C. and Li, Y. ID4 regulates mammary gland development by suppressing p38MAPK activity. Development 138, 5247-5256 (2011). PMID: 22069192. PMC3210500.
Zhu, M., Yi, M., Kim, C.H., Deng, C., Li, Y., Medina, D., Stephens, R.M. and Green, J.E. Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol 12, R77 (2011). PMID: 21846369. PMC3245617.
Batts, T.D., Machado, H.L., Zhang, Y., Creighton, C.J., Li, Y. and Rosen, J.M. Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration. PLoS One 6, e27841 (2011). PMID: 22140470. PMC3226565.
Reddy, J.P. and Li, Y. Oncogene-induced senescence and its role in tumor suppression. J Mammary Gland Biol Neoplasia 16, 247-256 (2011). PMID: 21681694
Liu, W., Xing, F., Iiizumi-Gairani, M., Okuda, H., Watabe, M., Pai, S.K., Pandey, P.R., Hirota, S., Kobayashi, A., Mo, Y.Y., Fukuda, K., Li, Y. and Watabe, K. N-myc downstream regulated gene 1 modulates Wnt-beta-catenin signalling and pleiotropically suppresses metastasis. EMBO Molecular Medicine 4, 93-108 (2012). PMID 22246988. PMCID 3306556.
Jackson, J.G., Pant, V., Li, Q., Chang, L.L., Quintas-Cardama, A., Garza, D., Tavana, O., Yang, P., Manshouri, T., Li, Y., El-Naggar, A.K. and Lozano, G. p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer. Cancer Cell 21, 793-806 (2012). PMID 22698404. PMCID 3376352.
Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes turmorigenesis. Mol Cell 48(5): 771-84 (2012). PMID: 23123196. PMCID: PMC3526114.
Zhang Y, Lv D, Kim HJ, Kurt RA, Bu W, Li Y, Ma X. A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells. Cell Res. 23(3) 394-408 (2013). PMID: 23266888. PMC3587709
Wang Y, Dong J, Li D, Lai L, Siwko S, Li Y, Liu M.. Lgr4 regulates mammary development and mammary stem cell self-renewal through the pluripotency transcription factor Sox2. Stem Cells. 31:1921-31 (2013). PMID: 23712846. PMC3934111.
Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu Z. Differential regulation of c-Jun plays an instrumental role in chemoresistance of cancer cells. J. Biol Chem. 288(27):19321-9 (2013). PMID: 23678002. PMC3707636.
Bu, W., Zhang, X., Dai, H., Huang, S. and Li, Y. Mammary Cells with Active Wnt Signaling Resist ErbB2-Induced Tumorigenesis. PLoS One 8, e78720 (2013). PMID 24265712. PMC3827100.
Haricharan, S., Dong, J., Hein, S., Reddy, J.P., Du, Z., Toneff, M., Holloway, K., Hilsenbeck, S.G., Huang, S., Atkinson, R., Woodward, W., Jindal, S., Borges, V.F., Gutierrez, C., Zhang, H., Schedin, P.J., Osborne, C.K., Tweardy, D.J. and Li, Y. Mechanism and preclinical prevention of increased breast cancer risk caused by pregnancy. eLife 2, e00996 (2013). PMID 24381245. PMC3874103
- Perspective: Chakravarthi, Varambally. 2013. Elife. 2: e01926.
Highlighted in the DOD-CDMRP Breast Cancer Awareness month, 2014
Highlighted in the CDMRP annual report to DOD, 2014
S. Haricharan, S. Hein, J. Dong, M. Toneff, O. Aina, P. H. Rao, R. Cardiff, Li. Y. Contribution of an alveolar cell of origin to the aggressive phenotype of pregnancy-associated breast cancer. Oncogene. 33(50):5729-39 (2014). PMID: 24317513. PMC4050040.
1and Zhang, P. Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis. PNAS 111, 1008-1013 (2014). PMID 24395789. PMCID 3903200.
Qin, L., Wu, Y.L., Toneff, M.J., Li, D., Liao, L., Gao, X., Bane, F.T., Tien, J.C., Xu, Y., Feng, Z., Yang, Z., Xu, Y., Theissen, S.M., Li, Y., Young, L. and Xu, J. NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. Cancer Res 74, 3477-3488 (2014). PMID 24769444. PMCID 4083628.
Michelle E. Doscas Q, Ashley J. Williamson, Lydia Usha, Yedida Bogachkov, Geetha S. Rao, Fei Xiao, Yimin Wang, Carl Ruby, Howard Kaufman, Jingsong Zhou, James W. Williams, Li, Y and Xiulong Xu. Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell proliferation and Cell Cycle Progress. Neoplasia. 16(10):824-34. (2014) PMID: 25379019. PMCID: PMC4212247.
Sinha, V.C., Qin, L. and Li, Y. A p53/ARF-dependent Anticancer Barrier Activates Senescence and Blocks Tumorigenesis without Impacting Apoptosis. Molecular cancer research (2014). 13(2): 231-8. PMID 25253740. PMCID: PMC4336810.
Haricharan, S. and Li, Y. STAT signaling in mammary gland differentiation, cell survival and tumorigenesis. Mol Cell Endocrinology. 382: 560–569. (2014) PMID: 23541951. PMC3748257.
Holloway, K.R., Sinha, V.C., Toneff, M.J., Bu, W., Hilsenbeck, S.G. and Li, Y. Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2. PLoS One 10, e0117239 (2015). PMID 25635772. PMCID 4311910.
Qin, L., Xu, Y., Xu, Y., Ma, G., Liao, L., Wu, Y., Li, Y., Wang, X., Wang, X., Jiang, J., Wang, J. and Xu, J. NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1alpha- and AP-1-mediated VEGFa transcription. Oncotarget 6, 23890-23904 (2015). PMID 26287601.
Zheng, Z.Y., Tian, L., Bu, W., Fan, C., Gao, X., Wang, H., Liao, Y.H., Li, Y., Lewis, M.T., Edwards, D., Zwaka, T.P., Hilsenbeck, S.G., Medina, D., Perou, C.M., Creighton, C.J., Zhang, X.H. and Chang, E.C. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell reports 12, 511-524 (2015). PMID 26166574. PMCID 4512851.
Shi, A., Dong, J., Hilsenbeck, S., Bi, L., Zhang, H. and Li, Y. The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia. PLoS One 10, e0132214 (2015). PMID 26146825. PMCID 4492667.
Ge, G.Z., Xia, H.J., He, B.L., Zhang, H.L., Liu, W.J., Shao, M., Wang, C.Y., Xiao, J., Ge, F., Li, F.B., Li, Y. and Chen, C. Generation and characterization of a breast carcinoma model by PyMT overexpression in mammary epithelial cells of tree shrew, an animal close to primates in evolution. Int J Cancer (2015). PMID 26296387.
Fang, X., Wei, J., He, X., An, P., Wang, H., Jiang, L., Shao, D., Liang, H., Li, Y., Wang, F. and Min, J. Landscape of dietary factors associated with risk of gastric cancer: A systematic review and dose-response meta-analysis of prospective cohort studies. European journal of cancer 51, 2820-2832 (2015). PMID 26589974.
Dong, J., Zhao, W., Shi, A., Toneff, M., Lydon, J., So, D. and Li, Y. The PR status of the originating cell of ER/PR-negative mouse mammary tumors. Oncogene (2016). 35:4149-54. PMID 26640140.
Hein, S.M., Haricharan, S., Johnston, A.N., Toneff, M.J., Reddy, J.P., Dong, J., Bu, W. and Li, Y. Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress. Oncogene 35, 1461-1467 (2016). PMID 26096929. PMCID 4688047.
Holloway, K.R., Sinha, V.C., Bu, W., Toneff, M., Dong, J., Peng, Y. and Li, Y. Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype. International journal of biological sciences 12, 381-388 (2016). PMID 27019623. PMCID 4807158.
Choi, S., Chen, Z., Tang, L.H., Fang, Y., Shin, S.J., Panarelli, N.C., Chen, Y.T., Li, Y., Jiang, X. and Du, Y.C. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nature communications 7: 10384 (2016). PMID 26785948. PMCID 4735924.
Williamson, A.J., Doscas, M.E., Ye, J., Heiden, K.B., Xing, M., Li, Y., Prinz, R.A. and Xu, X. The sonic hedgehog signaling pathway stimulates anaplastic thyroid cancer cell motility and invasiveness by activating Akt and c-Met. Oncotarget (2016) 7:10472-85. PMID 26859575.
Welte, T., Kim, I.S., Tian, L., Gao, X., Wang, H., Li, J., Holdman, X.B., Herschkowitz, J.I., Pond, A., Xie, G., Kurley, S., Nguyen, T., Liao, L., Dobrolecki, L.E., Pang, L., Mo, Q., Edwards, D.P., Huang, S., Xin, L., Xu, J., Li, Y., Lewis, M.T., Wang, T., Westbrook, T.F., Rosen, J.M. and Zhang, X.H. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nature Cell Biology 18, 632-644 (2016). PMID 27183469. PMCID 4884142.
Xu, X., Rao, G. and Li, Y. Xanthine oxidoreductase is required for genotoxic stress-induced NKG2D ligand expression and gemcitabine-mediated antitumor activity. Oncotarget 7, 59220-59235 (2016). PMID 27494876.
Pham, K., Dong, J., Jiang, X., Qu, Y., Yu, H., Yang, Y., Olea, W., Marini, J.C., Chan, L., Wang, J., Wehrens, X.H., Cui, X., Li, Y., Hadsell, D.L. and Cheng, N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. American Journal of Physiology. Endocrinology and Metabolism 312, E136-E149 (2017). PMID 27894063. PMCID 5374299.
Xu, X., Sun, J., Song, R., Doscas, M.E., Williamson, A.J., Zhou, J., Sun, J., Jiao, X., Liu, X. and Li, Y. Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation. Oncotarget 8, 30438-30454 (2017). PMID 28389629. PMCID 5444754.
Wang, W., Meng, Y., Dong, B., Dong, J., Ittmann, M.M., Creighton, C.J., Lu, Y., Zhang, H., Shen, T., Wang, J., Rowley, D.R., Li, Y., Chen, F., Moore, D.D. and Yang, F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia 19, 421-428 (2017). PMID 28433771. PMCID 5402631.
Qin, L., Xu, Y., Yu, X., Toneff, M.J., Li, D., Liao, L., Martinez, J.D., Li, Y. and Xu, J. The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland. Oncotarget 8, 84761-84775 (2017). PMID 29156681. PMCID 5689571.
Xu, Y., Lee, D.K., Feng, Z., Xu, Y., Bu, W., Li, Y., Liao, L. and Xu, J. Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice. PNAS 114, 11494-11499 (2017). PMID 29073077. PMCID 5664488.
Yu, Y., Gu, S., Li, W., Sun, C., Chen, F., Xiao, M., Wang, L., Xu, D., Li, Y., Ding, C., Xia, Z., Li, Y., Ye, S., Xu, P., Zhao, B., Qin, J., Chen, Y.G., Lin, X. and Feng, X.H. Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-beta signaling. PNAS 114, 10113-10118 (2017). PMID 28874583. PMCID 5617276.
Xiulong Xu, Yurong Lu, Yi Li, Richard A. Prinz. Sonic hedgehog signaling in thyroid cancer. Frontiers in Endocrinology. 8:284 (2017). PMID: 29163356 PMCID: PMC5670164.
Yue Z, Yuan Z, Zeng L, Wang Y, Lai L, Li J, Sun P, Xue X, Qi J, Yang Z, Zheng Y, Fang Y, Li D, Siwko S, Li Y, Luo J, Liu M. LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells. FASEB J. 2018. PMID: 29269400. PMCID: PMC5901378
Chen J, Sun J, Doscas ME, Ye J, Williamson AJ, Li Y, Li Y, Prinz RA, Xu X. Control of hyperglycemia in male mice by leflunomide: mechanisms of action. J. Endocrinology. 237(1):43-58. 2018. PMID: 29496905 PMCID: PMC5839151.
Sun J, Mu Y, Jiang Y, Song R, Yi J, Zhou J, Sun J, Jiao X, Prinz RA, Li Y, Xu X. Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates. Cell Death and Disease. 9 (3): 407 2018. PMID: 29540819.
Johnston, A.N., Bu, W., Hein, S., Garcia, S., Camacho, L., Xue, L., Qin, L., Nagi, C., Hilsenbeck, S.G., Kapali, J., Podsypanina, K., Nangia, J. and Li, Y. Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions. Breast Cancer Research: 20, 42 (2018). PMID 29778097.
Chen, J., Sun, J., Prinz, R.A., Li, Y. & Xu, X. Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase. Molecular nutrition & food research 62, e1800709 (2018). PMID 30296358. PMCID 6340301.
Bu, W., Liu, Z., Jiang, W., Nagi, C., Huang, S., Edwards, D.P., Jo, E., Mo, Q., Creighton, C.J., Hilsenbeck, S.G., Leavitt, A.D., Lewis, M.T., Wong, S.T.C. & Li, Y. Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes. Cancer Res (2018). PMID 30401712.
Zhang, Q., Xiao, M., Gu, S., Xu, Y., Liu, T., Li, H., Yu, Y., Qin, L., Zhu, Y., Chen, F., Wang, Y., Ding, C., Wu, H., Ji, H., Chen, Z., Zu, Y., Malkoski, S., Li, Y., Liang, T., Ji, J., Qin, J., Xu, P., Zhao, B., Shen, L., Lin, X. & Feng, X.H. ALK phosphorylates SMAD4 on tyrosine to disable TGF-beta tumour suppressor functions. Nature cell biology 21, 179-189 (2019). PMID 30664791..
Yuan, B., Liu, J., Cao, J., Yu, Y., Zhang, H., Wang, F., Zhu, Y., Xiao, M., Liu, S., Ye, Y., Ma, L., Xu, D., Xu, N., Li, Y., Zhao, B., Xu, P., Jin, J., Xu, J., Chen, X., Shen, L., Lin, X. & Feng, X.H. PTPN3 acts as a tumor suppressor and boosts TGF-β signaling independent of its phosphatase activity. EMBO J. 38, e99945 (2019). PMID 31304624. PMCID 6627230..
Kim, I.S., Gao, Y., Welte, T., Wang, H., Liu, J., Janghorban, M., Sheng, K., Niu, Y., Goldstein, A., Zhao, N., Bado, I., Lo, H.C., Toneff, M.J., Nguyen, T., Bu, W., Jiang, W., Arnold, J., Gu, F., He, J., Jebakumar, D., Walker, K., Li, Y., Mo, Q., Westbrook, T.F., Zong, C., Rao, A., Sreekumar, A., Rosen, J.M. & Zhang, X.H. Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms. Nature cell biology 21, 1113-1126 (2019). PMID 31451770. PMCID 6726554.
Xue, L., Chen, F., Yue, F., Camacho, L., Kothapalli, S., Wei, G., Huang, S., Mo, Q., Ma, F., Li, Y. & Jiralerspong, S. Metformin and an insulin/IGF-1 receptor inhibitor are synergistic in blocking growth of triple-negative breast cancer. Breast Cancer Research and Treatment 185, 73-84 (2021). PMID 32940848. PMCID 7855212.
Zhang, T., Na, J.H., Li, S., Chen, Z., Zhang, G., Pang, S., Daniyan, A.F., Li, Y., Shi, L. & Du, Y.N. Functional impact of cancer patient-associated Bcl-xL mutations. MedComm 1, 328-337 (2020). PMID 34308416. PMCID 8302207.
Bu, W. & Li, Y. Intraductal Injection of Lentivirus Vectors for Stably Introducing Genes into Rat Mammary Epithelial Cells in Vivo. J Mammary Gland Biol Neoplasia 25, 389-396 (2020). PMID 33165800. PMCID 7965254.
Zhang, W., Bado, I.L., Hu, J., Wan, Y.W., Wu, L., Wang, H., Gao, Y., Jeong, H.H., Xu, Z., Hao, X., Lege, B.M., Al-Ouran, R., Li, L., Li, J., Yu, L., Singh, S., Lo, H.C., Niu, M., Liu, J., Jiang, W., Li, Y., Wong, S.T.C., Cheng, C., Liu, Z. & Zhang, X.H. The bone microenvironment invigorates metastatic seeds for further dissemination. Cell 184, 2471-2486 e2420 (2021). PMID 33878291. PMCID 8087656.
Ding, Y., Liu, Y., Lee, D.K., Tong, Z., Yu, X., Li, Y., Xu, Y., Lanz, R.B., O'Malley, B.W. & Xu, J. Cell lineage tracing links ERalpha loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype. PNAS 118 (2021). PMID 34006643. PMCID 8166171.
Yue, F., Jiang, W., Ku, A.T., Young, A.I.J., Zhang, W., Souto, E.P., Gao, Y., Yu, Z., Wang, Y., Creighton, C.J., Nagi, C., Wang, T., Hilsenbeck, S.G., Feng, X.H., Huang, S., Coarfa, C., Zhang, X.H., Liu, Q., Lin, X. & Li, Y. A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Res (Cover) 81, 4441-4454 (2021). PMID 34099494. PMCID 8416783.
Young, A.I.J., Bu, W., Jiang, W., Ku, A.T., Kapali, J., Dhamne, S., Qin, L., Hilsenbeck, S.G., Du, Y.N. & Li, Y. Targeting the Pro-Survival Protein BCL-2 to Prevent Breast Cancer. Cancer Prevention Research (2021). PMID 34667127.
Martinez, J.D., Mo, Q., Xu, Y., Qin, L., Li, Y. & Xu, J. Common Genomic Aberrations in Mouse and Human Breast Cancers with Concurrent P53 Deficiency and Activated PTEN-PI3K-AKT Pathway. International journal of biological sciences 18, 229-241 (2022). PMID 34975329. PMCID 8692138.
Yue, Z., Niu, X., Yuan, Z., Qin, Q., Jiang, W., He, L., Gao, J., Ding, Y., Liu, Y., Xu, Z., Li, Z., Yang, Z., Li, R., Xue, X., Gao, Y., Yue, F., Zhang, X.H., Hu, G., Wang, Y., Li, Y., Chen, G., Siwko, S., Gartland, A., Wang, N., Xiao, J., Liu, M. & Luo, J. RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis. The Journal of clinical investigation 132 (2022). PMID 34847079. PMCID PMC8759794.
Wang, X., Shi, Z., Lu, H.Y., Kim, J.J., Bu, W., Villalobos, J.A., Perera, D.N., Jung, S.Y., Wang, T., Grimm, S.L., Taylor, B.C., Rajapakshe, K., Park, H., Wulfkuhle, J., Young, N.L., Li, Y., Coarfa, C., Edwards, D.P. & Huang, S. High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array. Journal of proteomics 262, 104596 (2022). PMID 35489683.
Zhang, T., Zhang, G., Chen, X., Chen, Z., Tan, A.Y., Lin, A., Zhang, C., Torres, L.K., Bajrami, S., Zhang, T., Zhang, G., Xiang, J.Z., Hissong, E.M., Chen, Y.T., Li, Y. & Du, Y.N. Low-dose carbon monoxide suppresses metastatic progression of disseminated cancer cells. Cancer Letters 546, 215831 (2022). PMID 35868533.
Lin, M., Ku, A.T., Dong, J., Yue, F., Jiang, W., Ibrahim, A.A., Peng, F., Creighton, C.J., Nagi, C., Gutierrez, C., Rosen, J.M., Zhang, X.H., Hilsenbeck, S.G., Chen, X., Du, Y.N., Huang, S., Shi, A., Fan, Z. & Li, Y. STAT5 confers lactogenic properties in breast tumorigenesis and restricts metastatic potential. Oncogene (2022). 41:5214-5222. PMID 36261627.
Zeng, L., Zhang, H.Y., Yang, C.Y., Cheng, Z., Jiang, Q.Y., Luo, Y., Li, Y., Li, F.B. & Chen, C.S. Generation of a tree shrew breast cancer model using lentivirus expressing PIK3CA- H1047R. Zool Res 44, 94-97 (2023). PMID 36376241.
Ku, A.T., Young, A.I.J., Ibrahim, A.A., Bu, W., Jiang, W., Lin, M., Williams, L.C., McCue, B.L., Miles, G., Nagi, C., Behbod, F. & Li, Y. Short-term PI3K Inhibition Prevents Breast Cancer in Preclinical Models. Cancer Prevention Research (Cover) 16, 65-73 (2023). PMID 36343340. PMCID PMC9905287.
Bu, W. & Li, Y. Advances in Immunocompetent Mouse and Rat Models. Cold Spring Harb Perspect Med (2023). PMID 37217281. PMCID 10810718.
Bu, W. & Li, Y. In Vivo Gene Delivery into Mouse Mammary Epithelial Cells Through Mammary Intraductal Injection. Journal of visualized experiments: JoVE (2023). PMID 36847377.
Bu, W., Creighton, C.J., Heavener, K.S., Gutierrez, C., Dou, Y., Ku, A.T., Zhang, Y., Jiang, W., Urrutia, J., Jiang, W., Yue, F., Jia, L., Ibrahim, A., Zhang, B., Huang, S. & Li, Y. Efficient cancer modeling through CRISPR/Cas9/HDR-based somatic precision gene editing in mice. Sci Adv 9, eade0059 (2023). PMID 37172086. PMCID PMC10181191.
Dou, Y., Katsnelson, L., Gritsenko, M.A., Hu, Y., Reva, B., Hong, R., Wang, Y.T., Kolodziejczak, I., Lu, R.J., Tsai, C.F., Bu, W., Liu, W., Guo, X., An, E., Arend, R.C., Bavarva, J., Chen, L., Chu, R.K., Czekanski, A., Davoli, T., Demicco, E.G., DeLair, D., Devereaux, K., Dhanasekaran, S.M., Dottino, P., Dover, B., Fillmore, T.L., Foxall, M., Hermann, C.E., Hiltke, T., Hostetter, G., Jedryka, M., Jewell, S.D., Johnson, I., Kahn, A.G., Ku, A.T., Kumar-Sinha, C., Kurzawa, P., Lazar, A.J., Lazcano, R., Lei, J.T., Li, Y., Liao, Y., Lih, T.M., Lin, T.T., Martignetti, J.A., Masand, R.P., Matkowski, R., McKerrow, W., Mesri, M., Monroe, M.E., Moon, J., Moore, R.J., Nestor, M.D., Newton, C., Omelchenko, T., Omenn, G.S., Payne, S.H., Petyuk, V.A., Robles, A.I., Rodriguez, H., Ruggles, K.V., Rykunov, D., Savage, S.R., Schepmoes, A.A., Shi, T., Shi, Z., Tan, J., Taylor, M., Thiagarajan, M., Wang, J.M., Weitz, K.K., Wen, B., Williams, C.M., Wu, Y., Wyczalkowski, M.A., Yi, X., Zhang, X., Zhao, R., Mutch, D., Chinnaiyan, A.M., Smith, R.D., Nesvizhskii, A.I., Wang, P., Wiznerowicz, M., Ding, L., Mani, D.R., Zhang, H., Anderson, M.L., Rodland, K.D., Zhang, B., Liu, T. & Fenyo, D. Proteogenomic insights suggest druggable pathways in endometrial carcinoma. Cancer Cell 41, 1586-1605 e1515 (2023). PMID 37567170. PMCID 10631452
Fei Yue, Amy T. Ku , Payton Stevens , Megan Michalski , Weiyu Jiang , Jianghua Tu , Zhongcheng Shi , Yongchao Dou , Yi Wang , Xin-Hua Feng , Galen Hostetter , Xiangwei Wu , Shixia Huang , Noah Shroyer , Bing Zhang , Bart Williams , Qingyun Liu , Xia Lin, Li, Y. Loss of ZNRF3/RNF43 Unleashes EGFR in Cancer. eLIFE. Reviewed Preprint (2024)
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