Research

Lab Members

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Principal Investigator

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Nicole Provenza, Ph.D.

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Assistant Professor, Neurosurgery, Baylor College of Medicine
Adjunct Professor, Electrical and Computer Engineering, Rice University

Dr. Provenza is an assistant professor of Neurosurgery and McNair Scholar at Baylor College of Medicine. She received her Ph.D. in biomedical engineering from Brown University and completed her postdoctoral fellowship at BCM. Provenza's research focuses on the neurophysiology underlying cognition and emotion and the effects of neuromodulation on neural activity and behavior. Her work integrates neural activity and deep phenotyping approcahes to inform neural signatures underlying real-world functional deficits in cognitive and emotional disorders. An improved understanding of the relationship between neural activity and behavior will enable the development of improved neuromodulation strategies that more effectively guide brain activity and behavior toward healthy states.

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Lab Members

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Tomasz Fraczek, Ph.D.

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Lead Data Scientist, Provenza and Sheth Labs
Tomek completed an undergraduate degree in physics at the University of California Santa Barbara, and then a Ph.D. in neuroscience at the University of Washington. During his Ph.D. work, he studied deep brain stimulation for motor disorders, with a particular focus on longitudinal monitoring and the remote chronic monitoring and data management systems this sort of data collection requires. In his free time, Tomek is an avid climber, skier, and sailor.
 

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Yewen Zhou, M.S.

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Software Engineering and Programming Associate, Provenza and Sheth Labs
Yewen earned an M.S. in data science from Columbia University and a B.A. in data science from U.S. Berkeley with a focus on business/industrial analytics. His professional background includes deep learning, machine learning, software engineering and data science related projects. Currently, he collaborates with lab members on projects involving video synchronization, TRBD dashboard setup and data archiving.

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Sai Chamarthi, B.S

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Research Technician
Sai is a recent graduate of Brown University with a B.S. in biomedical engineering. While there, she was interested in understanding the neural underpinnings of consciousness and conducted research investigating the role of distractors in temporal attention processing. With this lab, she hopes to continue her research training and further contribute to the development of neuromodulation therapies aimed at improving mental health experiences. She is also tangentially intrigued by public health, design/innovation and advocacy and hopes to bridge these interests in pursuing medical school in a couple years.

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Sameer Rajesh, B.S.

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Medical Student
Sameer is a medical student at U.T. Southwestern. He previously worked under Dr. Provenza in Dr. Sheth's lab, where he studied neural correlates of behavior and treatment response in patients with treatment-resistant OCD receiving deep brain stimulation. Now, he is continuing an analysis of neural correlates of symptom provocation in these patients. His interests are in anatomic and functional brain connectivity, as well as the mathematical and engineering tools we use to interrogate the brain. He plans to pursue neurosurgery.

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Zain Naqvi, B.S.

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Medical Student, Co-advised by Dr. Sheth
Zain is a third-year medical student at Baylor College of Medicine, planning to pursue a career in neurosurgery. This year, under the guidance of Dr. Sheth, he engaged in a research year through the Medical Research Pathway (MRP) program, before he applies for a neurological surgery residency. His research interests are centered on investigated neural biomarkers for psychiatric disorders and advancing neuromodulation techniques. Currently, his work involves collaborating with patients who have deep brain stimulation implants for OCD. He is actively involved in collecting and processing neural data from these patients and identify and characterize potential biomarkers and gain a deeper understanding of the OCD circuitry. This endeavor aims to pave the way for developing adaptive DBS systems tailored to individual needs.

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Tommy Liu, B.S.A.

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Medical Student, Co-advised by Dr. Sheth
Tommy is a second-year medical student at BCM, interested in applying for neurological surgery residency and currently taking a year off for research in the Medical Research Pathway. He received a B.S.A. from the University of Texas at Austin, majoring in neuroscience. Clinically, he is interested in neuromodulation therapies to treat psychiatric, cognitive and motor disorders. After his research year, he will rejoin the BCM Medical Class of 2027.

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Holden Bentley, B.S.

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Medical Student, Co-advised by Dr. Sheth
Holden is a third-year medical student, and intends to pursue a career in neurosurgery. He received a B.S. in biomedical engineering at the University of Texas at Austin in 2021. He is currently a student attending McGovern Medical School and is participating in a research year under the guidance of Dr. Nicole Provenza and Dr. Sameer Sheth. He is primarily interested in the application of deep brain stimulation to treatment-resistant psychiatric disorders and developing an understanding of human brain function in such patients. His work currently involves the collection and processing of neuronal data collected from OCD patients with DBS implants. His goal is to improve the application of DBS to these patients, and to discover novel ways to characterize OCD from neural data. Ultimately, this could allow for adaptive DBS (aDBS) systems to be created, which could revolutionize neuropsychiatric care.