DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
Project Goals: Type 2 diabetes used to be known as “adult-onset” diabetes and was thought to mostly affect people later in life. Now, more children are being diagnosed with type 2 diabetes. Rates of type 2 diabetes among children and adolescents are increasing rapidly over time. Currently, we do not understand why rates of type 2 diabetes is increasing in children. The DISCOVERY Study seeks to understand what factors cause some children to develop type 2 diabetes while others don’t.
DISCOVERY is a study for children 9-14 years old who may be at higher risk of developing type 2 diabetes. This study does not involve medications and there is no cost to you. You will be compensated for your time in this study. Join families across the US to help us make a difference for all children and young people!
Visit the study web site.
Type 2 Diabetes and Bone Health in Youth
Project Goals: This study aims to investigate prospectively the effect of hyperglycemia on bone accrual, quality and strength in youth onset type 2 diabetes (T2D) compared with obese controls with normal glucose tolerance; and to identify the hormonal and biochemical determinants of bone accrual and strength in youth onset T2D.
Bone Health and Metabolism in Youth with Obesity
Project 1 Goals: This study evaluates the effects of childhood obesity on bone formation and strength (bone microarchitecture) and the relationship of bone hormones to insulin sensitivity and vascular function.
Project 2 Goals: Investigate the interaction between childhood adiposity, insulin resistance and adipokine imbalance on bone health in Hispanic youth across pubertal stages and the modifying effect of physical activity.
Advanced glycation endproducts (AGEs), oxidation products and the soluble receptor for AGE (sRAGE): Cardiovascular Disease Risk Biomarkers in Youth with Type 2 Diabetes.
Project Goals: This study aims to investigate the role of the advanced glycation endproducts (AGEs), oxidation products, and the soluble receptor for AGEs (sRAGE) as biomarkers of microvascular and macrovascular disease in youth with type 2 diabetes.
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes
Project Goals: 1) To develop more precise prediction of risk of youth-onset type 2 diabetes (T2D); and 2) To understand of the physiologic drivers of youth T2D, to guide development of more effective therapeutic and prevention strategies.
Lab Studies
IRB Number: H-55870
Study Title: DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
Study Description: DISCOVERY will extensively phenotype a large cohort of youth at-risk for type 2 diabetes (T2D), as they transition through puberty, and characterize the course of dysfunction in pathophysiological indicators that lead to T2D.
Jesus Cazares, RC II: 713-798-7132 | jesus.cazares@bcm.edu| discovery@bcm.edu
IRB Number: H-45986
Study Title: Bone Health and Metabolism in Youth
Study Description: This study evaluates the effect of obesity and childhood onset diabetes and their associated adverse metabolic milieu on bone density, microarchitecture and bone biomarkers. In turn, the effect of these biomarkers on vascular function in youth will be assessed.
Victoria Sollock, RN, BSN; 713.798.6721 | Victoria.Sollock@bcm.edu
IRB Number: H-50574
Study Title: Type 2 diabetes and bone health in youth; A longitudial study
Study Description: This study investigates the effect of childhood onset diabetes on bone accrual, density, microarchitecture and bone biomarkers longitudinally over 12 months.
Victoria Sollock, RN, BSN; 713.798.6721 | Victoria.Sollock@bcm.edu
IRB Number: H-30665
Study Title: Determinants of subclinical coronary atherosclerosis and endothelial dysfunction in youth with and without type 2 diabetes
Status: Not currently enrolling
