DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
Project Goals: The primary objective of DISCOVERY is to identify the physiologic drivers and other determinants of progression to T2D by charting the course of changes in glycemia, β-cell function, insulin sensitivity, psychosocial, behavioral, and social determinants of health during this critical period of maturation and inform approaches for precise prediction of which youth are at highest risk of developing T2D.
Type 2 Diabetes and Bone Health in Youth
Project Goals: This study aims to investigate prospectively the effect of hyperglycemia on bone accrual, quality and strength in youth onset type 2 diabetes (T2D) compared with obese controls with normal glucose tolerance; and to identify the hormonal and biochemical determinants of bone accrual and strength in youth onset T2D.
Bone Health and Metabolism in Youth with Obesity
Project 1 Goals: This study evaluates the effects of childhood obesity on bone formation and strength (bone microarchitecture) and the relationship of bone hormones to insulin sensitivity and vascular function.
Project 2 Goals: Investigate the interaction between childhood adiposity, insulin resistance and adipokine imbalance on bone health in Hispanic youth across pubertal stages and the modifying effect of physical activity.
Advanced glycation endproducts (AGEs), oxidation products and the soluble receptor for AGE (sRAGE): Cardiovascular Disease Risk Biomarkers in Youth with Type 2 Diabetes.
Project Goals: This study aims to investigate the role of the advanced glycation endproducts (AGEs), oxidation products, and the soluble receptor for AGEs (sRAGE) as biomarkers of microvascular and macrovascular disease in youth with type 2 diabetes.
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes
Project Goals: 1) To develop more precise prediction of risk of youth-onset type 2 diabetes (T2D); and 2) To understand of the physiologic drivers of youth T2D, to guide development of more effective therapeutic and prevention strategies.
