Positions
- Professor
-
Medicine - Epidemiology & Population Science
Baylor College of Medicine
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas (TX)
Addresses
- N720 (Lab)
-
Alkek Building
One Baylor Plaza
Houston, TX 77030
United States
Phone: (713) 798-7506
Education
- BS from Lanzhou University
- Lanzhou
- PhD from Chinese Academy of Sciences
- Shanghai
- Postdoctoral Training at Yale University
- New Haven
Professional Interests
- Non-Hodgkin's Lymphoma & Multiple Myeloma
- Environmental carcinogenesis
- Genetic polymorphism
- Artificial intelligence
- Tumor antigens
Professional Statement
My research aims to elucidate the role of genetic and environmental etiological factors in cancer and to define the precise molecular and cellular events and genetic polymorphisms intersecting with environmental risk factors that are responsible for the epidemiological association, cancer initiation and progression, and clinical outcomes. The translational objective of my research is to develop therapeutic agents targeting oncoproteins and cancer/testis antigens.Selected Publications
- Yu X, Li W, Deng Q, Liu H, Wang X, Hu H, Cao Y, Xu-Monette ZY, Li L, Zhang M, Lu Z, Young KH, Li Y "MYD88 L265P elicits mutation-specific ubiquitination to drive NF-κB activation and lymphomagenesis." Blood. 2021;137(12):1615-1627. Pubmed PMID: 33025009
- Wang L, Deng Q, Hu H, Liu M, Gong Z, Zhang S, Xu-Monette ZY, Lu Z, Young KH, Ma X, Li Y "Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice." J Hematol Oncol. 2019;12(1):70. Pubmed PMID: 31277689
- Li Y, Gordon MW, Xu-Monette ZY, Visco C, Tzankov A, Zou D, Qiu L, Montes-Moreno S, Dybkaer K, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huang Q, Ai W, Ponzoni M, Ferreri AJ, Winter JN, Go RS, Piris MA, et al "Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program." Blood. 2013;121(22):4529-40. Pubmed PMID: 23515929
- Takwi A., Li, Y., Buscaglia L.E.B., Zhang J. Choudhury S., Park A.K., Liu, M., Young K.H., Park WY. Martin R.C.G., Li, Y "A Statin-regulated MicroRNA Represses Human c-Myc Expression and Function." EMBO Mol Med. 2012;4(9):896-909. Pubmed PMID: 22887866
- Yu X, Li W, Liu H, Deng Q, Wang X, Hu H, Xu-Monette ZY, Xiong W, Lu Z, Young KH, Wang W, Li Y. "Ubiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation." J Hematol Oncol. 2020;13:40. Pubmed PMID: 32357935
- Fan C, Qu H, Wang X, Sobhani N, Wang L, Liu S, Xiong W, Zeng Z, Li Y "Cancer/Testis Antigens: from Serology to mRNA Cancer Vaccine." Semin Cancer Biol. 2021;76:218-231. Pubmed PMID: 33910064
- Ma X, Conklin DJ, Li F, Dai Z, Hua X, Li Y, Xu-Monette ZY, Young, KH, Xiong W, Wysoczynski, Sithu SD, Srivastava A, Bhatnagar A, Li, Y "The Oncogenic MicroRNA miR-21 Promotes Regulated Necrosis in Mice." Nature Comm. 2015;6:7151. Pubmed PMID: 25990308
- Ma, X., Kumar, M., Choudhury, S.N., Buscaglia, L.E.B., Barker J.R., Kanakamedala, K., Liu, M., Li, Y "Loss of the miR-21 Allele Elevates the Expression of its Target Genes and Reduces Tumorigenesis." Proc Natl Acad Sci USA. 2011;108(25):10144-9. Pubmed PMID: 21646541
Memberships
- American Association for Cancer Research
- American Society of Hematology
- American Association for the Advancement of Science
- Society of Toxicology
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