Xue Deng, Ph.D.
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Xue Deng, Ph.D.
Postdoctoral Associate
Positions
- Postdoctoral Associate
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Molecular & Human Genetics - Zoghbi Lab
Baylor College of Medicine
Education
- PhD from University of Chinese Academy of Sciences
- 01/2022 - Shanghai, Shanghai China
Professional Interests
- Neurodegenerative diseases
Selected Publications
- Shu S*, Jiang M*, Deng X*, Yue W, Cao X, Zhang K, Wang Z, He H, Cui J, Wang Q, Qu K, Fang Y "Heterochromatic silencing of immune-related genes in glia is required for BBB integrity and normal lifespan in drosophila." Aging Cell. 2023 Oct; Pubmed PMID: 37594178
- Yue W*, Deng X*, Wang Z, Jiang M, Hu R, Duan Y, Wang Q, Cui J, Fang Y "Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS." Immun Ageing. 2023 Jun; Pubmed PMID: 37340309
- Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A, Fang Y "CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1." J Cell Biol. 2022 Jan; Pubmed PMID: 34726688
- Wang C, Duan Y, Duan G, Wang Q, Zhang K, Deng X, Qian B, Gu J, Ma Z, Zhang S, Guo L, Liu C, Fang Y "Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation." Mol Cell. 2020 Aug 6; Pubmed PMID: 32649883
- Sun X, Duan Y, Qin C, Li JC, Duan G, Deng X, Ni J, Cao X, Xiang K, Tian K, Chen CH, Li A, Fang Y "Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy." Cell Death Dis. 2018 Sep; Pubmed PMID: 30237395
- Duan Y, Du A, Gu J, Duan G, Wang C, Gui X, Ma Z, Qian B, Deng X, Zhang K, Sun L, Tian K, Zhang Y, Jiang H, Liu C, Fang Y "PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins." Cell Res. 2019 Mar; Pubmed PMID: 30728452
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