Vishnu Dileep
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Vishnu Dileep
Assistant Professor, CPRIT Scholar
Positions
- Assistant Professor, CPRIT Scholar
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Huffington Center on Aging
Baylor College of Medicine
Houston
- Assistant Professor
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Department of Molecular and Human Genetics
Baylor Colleg of Medicine
Education
- PhD from Florida State University
- Tallahassee, Florida United States
- Cell and Molecular Biology
- Postdoctoral Training at Massachusetts Institute of Technology
- Cambridge, Massachusetts United States
Professional Statement
The brain comprises several specialized cell types, some of which, like neurons and oligodendrocytes, can live for decades or as long as the organism itself. This longevity brings the challenge of maintaining their genomic and epigenomic integrity to preserve cellular function. Our lab investigates the organization of the genome and epigenome in brain cells, focusing on the molecular changes that drive brain aging and neurodegeneration.Our goal is to understand how alterations in the genetic material and its regulation at the molecular level contribute to functional changes in brain aging and age-related neurological diseases at cellular and organismal scales. To achieve this, we investigate the genome from the linear sequence level to the large-scale 3D architecture of the genome, including enhancer-promoter interactions that regulate gene expression. Within this framework, our immediate focus is on how DNA damage accumulation in aging and neurological diseases disrupts genome organization and integrity. By establishing cause-effect relationships in these processes, we aim to uncover new therapeutic targets to mitigate or reverse brain aging and age-related neurological diseases.
Funding
- R00- Pathway to Independence Award - #R00 AG073466 (09/11/2024 - 10/20/2027) Grant funding from NIH
- Recruitment of First-Time, Tenure-Track Faculty Members - #RR240027 (08/09/2024 - 08/08/2029) Grant funding from CPRIT
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