Valerie Sandra LeBleu, MBA MD PhD
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Valerie Sandra LeBleu, MBA MD PhD
Education
- BS from Florida Institute of Technology
- 12/2003 - Melbourne, Florida United States
- PhD from Harvard University
- 06/2009 - Boston, Massachusetts United States
- MD from Northwestern Feinberg School of Medicine
- 05/2023 - Chicago, Illinois United States
- MBA from Northwestern Kellogg School of Management
- 05/2023 - Chicago, Illinois United States
Honors & Awards
- James P. and Christine M. Kelly Family Medical Scholarship
- Feinberg School of Medicine, Northwestern University (06/2022)
- National Kidney Foundation of Illinois
- Medical Student Research Grant Award (06/2019)
- Wilson S. Stone Award
- The University of Texas MD Anderson Cancer Center (06/2015)
- Rising STARS Science and Technology Acquisition and Retention
- The University of Texas MD Anderson Cancer Center (06/2014)
- Young Ambassador Award
- Metastasis Research Society (06/2012)
- Fellow
- FDA-AACR Oncology Educational Fellowship (08/2022 - 06/2023)
- Scholar
- MeRIT (Medical Resident Investigator Track) Scholar, Baylor College of Medicine, (06/2023 - 06/2027)
Selected Publications
- Mahadevan KK, LeBleu VS , Ramirez EV [...] DePinho RA, Anirban Maitra A, McAndrews KM, Raghu Kalluri R "Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells." Dev Cell. 2023 Aug 24;58(17):1562-1577. Pubmed PMID: 37625403
- Haltom AR [...] LeBleu VS, Kalluri R "Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma." Extracell Vesicle. 2022 Oct 27;1(100014) Pubmed PMID: 37503329
- McAndrews KM, [...] LeBleu VS, Kalluri R "Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL6-Mediated Therapy Resistance in Pancreatic Cancer." Cancer Discov. 2022 Jun 2;12(6):1580-1597.. Pubmed PMID: 35348629
- LeBleu VS [...] Tainer J, Zon LI, Kallur R "Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish." Dev Dyn. 2023 Apr 17;252(7):1046-1060. Pubmed PMID: 37002899
- Mahadeva KK, McAndrews KM, LeBleu VS, [...], Maitra A, Heffernan TP, Kalluri R "KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells." Cancer Cell. 2023 Aug 24;41(9):1606-1620. Pubmed PMID: 37625401
- LeBleu VS "Plasticity Enables Cooperation among Heterogeneous Cancer Cell Populations to Support Metastatic Fitness." Cancer Res. 2022 May 22;82(10):1870-1871. Pubmed PMID: 35570704
- LeBleu VS & Thiery JP "The Continuing Search for Causality between Epithelial-to-Mesenchymal Transition and the Metastatic Fitness of Carcinoma Cells." Cancer Res. 2022 Apr 15;82(8):1467-1469. Pubmed PMID: 35425957
- El-Shennawy L, [...] Lebleu VS, [...] Liu H "Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2." Nat Commun. 2022 Jan 20;13(1):405. Pubmed PMID: 35058437
- McAndrews KM, [...] LeBleu VS, Ge Y, Kalluri R "Dermal αSMA+ myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production." EMBO J. 2022 Feb 25;41(7):e109470. Pubmed PMID: 35212000
- Zhou X, [...] LeBleu VS, [...] Kalluri R "Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer." Mol Ther Methods Clin Dev. 2021 May 29;22:360-376. Pubmed PMID: 34514028
- McAndrews KM, [...] LeBleu VS, Kalluri R "αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression." Oncogene. 2021 Jun 9;40(26):4440-4452. Pubmed PMID: 34108617
- McAndrews KM, [...] LeBleu VS, Kugeratski FG, Kalluri R "Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer." Life Sci Alliance. 2021 Jul 19;4(9):e202000875. Pubmed PMID: 34282051
- Hensel J, [...] LeBleu VS, Kalluri R "Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses." Sci Rep. 2020 Oct 27;10(1):18377. Pubmed PMID: 33110184
- Tang M, [...] LeBleu VS, McAndrews KM, Kalluri R "Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis." FASEB. 2021 May;35(5):e21557. Pubmed PMID: 33855751
- Chen Y, [...] LeBleu VS, Kalluri R "Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer." Cancer Cell. 2021 Apr 12;39(4):548-565. Pubmed PMID: 33667385
- McAndrews KM, Che SPY, LeBleu VS, Kalluri R "Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity." J Biol Chem. 2021 Jan;296:100523. Pubmed PMID: 33711340
- LeBleu VS, Kanasaki K, Lovisa S, Alge JL, Kim J, Chen Y, Teng Y, Gerami-Naini B, Sugimoto H, Kato N, Revuelta I, Grau N, Sleeman JP, Taduri G, Kizu A, Rafii S, Hochedlinger K, Quaggin SE, Kalluri R. "Genetic reprogramming with stem cells regenerates glomerular epithelial podocytes in Alport syndrome." Life Sci Alliance. 2024 Apr 1;7(6):e202402664. Pubmed PMID: 38561223
- 55. McAndrews KM, Chen Y, Darpolor JK, Zheng X, Yang S, Carstens JL, Li B, Wang H, Miyake T, Correa de Sampaio P, Kirtley ML, Natale M, Wu CC, Sugimoto H, LeBleu VS, Kalluri R. "Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer." Cancer Discovery. 2022 Mar 29; Pubmed PMID: 35348629
- 45. McAndrews KM, Dowlatshahi DP, Dai J, Becker LM, Hensel J, Snowden LM, Leveille JM, Brunner MR, Holden KW, Hopkins NS, Harris AM, Kumpati J, Whitt MA, Lee JJ, Ostrosky-Zeichner LL, Papanna R, LeBleu VS, Allison JP, Kalluri R. "Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity." JCI Insight. 2020 Sep 17;5(18):e142386. Pubmed PMID: 32796155
- Becker LM, O'Connell JT, Vo AP, Cain MP, Tampe D, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, McAndrews KM, Zielinski R, Lorenzi PL, Zeisberg M, Raza S, LeBleu VS, Kalluri R. "Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer." Cell Reports. 2020 Jun 2;31(9):107701. Pubmed PMID: 32492417
- Lovisa S, Fletcher-Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, Taduri G, Lawson E, Dewar R, Revuelta I, Kato N, Wu CJ, Bassett RL Jr, Putluri N, Zeisberg M, Zeisberg EM, LeBleu VS, Kalluri R "Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis." Sci Signal. 2020 Jun 9;13(365):eaaz2597. Pubmed PMID: 32518142
Languages
French
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