Srinivas Chamakuri
Picture
Srinivas Chamakuri
Assistant Professor
Positions
- Assistant Professor
-
Pathology
Baylor College of Medicine
Houston, TX USA
Education
- MSc from Osmania University
- 05/2008 - Hyderabad, India
- PhD from University of Hyderabad
- 01/2015 - Hyderabad, India
- Postdoctoral Training at Baylor College of Medicine
- 05/2020 - Houston, Texas United States
Professional Interests
- Synthetic Organic Chemistry
- Medicinal Chemistry
- DNA Encoded Library Technology
- Fragment-based Drug Discovery
- Diversity-Oriented Synthesis
- Chemical Biology
Websites
ViiCTR Profile
Google Scholor
Selected Publications
- Sunny Ann Tang, Afton Fults, Shelton R Boyd, Nikhil Gattu, Kevin A Tran, Jiayi Fan, Kevin R MacKenzie, Timothy Palzkill, Damian W Young, Srinivas Chamakuri* "Expanding Complex Morpholines Using Systematic Chemical Diversity." Org. Lett. 2024 Mar 20; Pubmed PMID: 38506470
- Suhyeorn Park, Jiayi Fan, Srinivas Chamakuri, Martin M Matzuk, Timothy Palzkill "Exploiting the Carboxylate-Binding Pocket of β-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library." J. Med. Chem. 2023 Dec 20;67(1):620-642. Pubmed PMID: 38117688
- Ravikumar Jimmidi, Srinivas Chamakuri*, Shuo Lu, Reuben S Harris, Martin M Matzuk, Timothy Palzkill, Damian W Young "DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors." 2023 Aug 4;6(1):164. Pubmed PMID: 37542196
- Amol B Viveki, Timothy M Mansfield, Kevin A Tran, Evan Lenkeit, Kevin R MacKenzie, Damian W Young, Srinivas Chamakuri* "Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles." Chem. E .J. 2023 Jul 18;29(55):e202301888. Pubmed PMID: 37462979
- Secondra Holmes, Prashi Jain, Srinivas Chamakuri, Martin M Matzuk, Conrad Santini, Kevin R MacKenzie, Damian W Young "Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1." Acs. Med. Chem. Lett.. 2024 Jan 2;15(1):107-115. Pubmed PMID: 38229743
- Damian W Young, Srinivas Chamakuri "Trisubstituted triumph." Nature Chemistry volume 14, pages595–597 (2022). 2022;14:595–597. Pubmed PMID: 35668207
- Srinivas Chamakuri*, Sunny Ann Tang, Kevin A Tran, Shiva Krishna Reddy Guduru, Peter K Bolin, Kevin R MacKenzie, Damian W Young* "A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1, 2-Diamines." Molecules. 2022;27(11):3419. Pubmed PMID: 35684357
- Prasanna Kandel, Fatih Semerci, Rachana Mishra, Srinivas Chamakuri, David D Moore, Damian W Young, Mirjana Maletic-Savatic "Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis." PNAS. 2022;119(13):e2023784119. Pubmed PMID: 35333654
- Chamakuri, S.; Lu, S.; Ucisik, M. N.; Bohren, K. M.; Chen, Y.-C.; Matzuk, M. M.; Palzkill, T.; Young, D. W. "DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors." Proceedings of the National Academy of Sciences. 2021;118(36):e2111172118. Pubmed PMID: 34426525
- Chamakuri, S*.; Chung, M. -K.; Santini, C.; Matzuk, M. M.; Young, D.W*. "Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library." Bioorg Med Chem. 2021;48(15):116387. Pubmed PMID: 34571488
- Elizabeth A Bowling, Jarey H Wang, Fade Gong, Srinivas Chamakuri, Damian W. Young, Thomas F Westbrook "Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer." Cell. 2021;184(2):384-403. e21. Pubmed PMID: 33450205
- Olivier BC Monty, Nicholas Simmons, Srinivas Chamakuri, Martin M Matzuk, Damian W Young "Solution-phase Fmoc-based peptide synthesis for DNA-encoded chemical libraries: Reaction conditions, protecting group strategies, and pitfalls." ACS Combi Science. 2020;22(12):833-843. Pubmed PMID: 33074645
- Prashi Jain, Idris O. Raji, Srinivas Chamakuri, Kevin R. MacKenzie, Brandon T. Ebright, Conrad Santini, Damian W. Young "Synthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production." J Org Chem. 2019;84(10):6040-6064. Pubmed PMID: 30848904
- Srinivas Chamakuri, Prashi Jain, Shiva Krishna Reddy Guduru, J Winston Arney 1, Kevin R MacKenzie, Conrad Santini, Damian W Young* "Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production." J Org Chem. 2018;83(12):6541–6555. Pubmed PMID: 29751727
- Shiva Krishna Reddy Guduru, Srinivas Chamakuri, Idris O Raji, Kevin R MacKenzie, Conrad Santini, Damian W Young "Synthesis of enantiomerically pure 3-substituted piperazine-2-acetic acid esters as intermediates for library production." J Org Chem. 2018;83(19):11777-11793. Pubmed PMID: 30180575
- Jeffery A Erickson, Ravikumar Jimmidi, Prashanth Anamthathmakula, Xuan Qin, Jian Wang, Leyi Gong, Jaehyeon Park, Gary Koolpe, Caitlin Tan, Martin M Matzuk, Feng Li, Srinivas Chamakuri*, Wipawee Winuthayanon* "Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen." Acs. Med. Chem. Lett.. 2024 Aug 5;15(9):1526-1532. Pubmed PMID: 39291021
- Angela F Ku, Kiran L Sharma, Hai Minh Ta, Courtney M Sutton, Kurt M Bohren, Yong Wang, Srinivas Chamakuri, Ruihong Chen, Choel Kim, Martin M Matzuk et ak., "Reversible male contraception by targeted inhibition of serine/threonine kinase 33." Science. 2024 May 23;384(6698):885-890. Pubmed PMID: 38781365
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