Sebastian Acosta, Ph.D.
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Sebastian Acosta, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Pediatrics - Critical Care
Analytics Laboratory
Baylor College of Medicine
Houston, TX US
Education
- PhD from Rice University
- 05/2014 - Houston, Texas United States
- Computational and Applied Mathematics, Biomechanics and Inverse Problems
- MS from Brigham Young University
- 05/2011 - Provo, Utah United States
- Mathematics, Partial Differential Equations
- BS from Brigham Young University
- 05/2009 - Provo, Utah United States
- Mechanical Engineering, Fluid Dynamics
Honors & Awards
- AMS-Simons Travel Grant 2015-2017
- BP Scholarship Award in Science 2012
- Selected Participant SIAM Summer School on Waves and Imaging 2011
- Graduate Research Award BYU Math 2011
- Graduate Research Fellowship BYU Math 2010
- Orson Pratt Prize for most outstanding graduating senior, BYU Math 2009
- Brigham Young Bicentennial Scholar
- World Young Researchers for the Environment WYRE 2000
- NSF-DMS Grant
- 07/2017 - 06/2020
- NIH-NIBIB grant
Professional Interests
- Computational Biomechanics
- Inverse Problems and Imaging
- Machine Learning, predictive analytics for critical care
Professional Statement
Advanced computational methods and artificial intelligence are becoming a promising factor to improve the assessment and treatment of pathological conditions. My goal is to further this line of scientific endeavor and reinforce the translation of quantitative methods into clinical practice. I am an interdisciplinary scientist who works at the interface between mathematics, statistics, engineering and medicine. My areas of expertise are biomechanics, computational science, and mathematical and statistical methods of inference. Current applications include predictive analytics for the deterioration of ICU patients, for hemodynamic irregularities, improving quality and automation of ultrasound-based imaging, photoacoustic imaging, decision-making, and planning/scheduling optimization.Websites
Selected Publications
- S. Acosta, D. Penny, C. Rusin "An effective model of blood flow in capillary beds." Microvasc. Res.. 2015;100:40-47.
- S. Acosta and C. Montalto "Multiwave imaging in an enclosure with variable wave speed." Inverse Problems. 2015;31:065009.
- S. Acosta, C. Puelz, B. Riviere, D. Penny, C. Rusin "Numerical method of characteristics for one-dimensional blood flow." J. COmput. Phys.. 2015;294:96-109.
- S. Acosta "A control approach to recover the wave speed (conformal factor) from one measurement." Inverse Prob & Imaging. 2015;9:301-315.
- S. Acosta "On-surface radiation condition for multiple scattering of waves." Comput. Meth. Appl. Mech. Engrg. 2015;283:1296-1309.
- S. Acosta "Time reversal for radiative transport with applications to inverse and control problems." Inverse Problems. 2013;29:085014.
- S. Acosta, S. Chow, J. Taylor, V. Villamizar "On the multi-frequency inverse source problem in heterogeneous media." Inverse Prob.. 2012;28:075013.
- C. Rusin, S. Acosta, L. Shekerdemian, E. Vu, A. Bavare, R. Myers, L. Patterson, K. Brady, D. Penny "Prediction of imminent, severe deterioration of children with parallel circulations using real-time processing of physiologic data." J. Thoracic Cardiovasc. Surg.. 2016;152:171-177.
- S. Acosta "Recovery of the absorption coefficient in radiative transport from a single measurement." Inverse Probl & Imaging. 2015;9:289-300.
- S. Acosta, R. Alonso, L. Borcea "Source estimation with incoherent waves in random waveguides." Inverse Prob.. 2015;31:035013.
- R. Wagner, S. Acosta, S. Glasgow, Q. Su, and R. Grobe "Quantum fluctuations in the dressed vacuum of a bosonic model system." J. Phys. A. 2012;45:275303.
- S. Acosta, V. Villamizar and B. Malone "The DtN nonreflecting boundary condition for multiple scattering problems in the half-plane." Comput. Meth. Appl. Mech. Engrg. 2012;217:1-11.
- S. Acosta, D. Penny, K. Brady, C. Rusin "An effective model of cerebrovascular pressure reactivity and blood flow autoregulation." Microvascular Research. 2018;115:34-43.
- S. Acosta, M. Ahmed, S. Yin, K. Brady, D. Penny, C. Rusin "A robust Fourier-based method to measure pulse pressure variability." Biomedical Signal Processing and Control. 2020;60:101947.
- S. Acosta, C. Puelz, D. Penny, B. Riviere, K. Brady, C. Rusin "Cardiovascular mechanics in the early stages of pulmonary hypertension." Biomech. Model. Mechanobio.. 2017;
- S. Acosta "High order surface radiation conditions for time-harmonic waves in exterior domains." Comput. Meth. Appl. Mech. Egnrg.. 2017;32:296-310.
- Barbara-Jo Achuff; Brady Moffett; Sebastian Acosta; Javier Lasa; Paul Checchia; Craig Rusin "Hemodynamic response to IV Acetaminophen in pediatric cardiac patients." Critical Care Medicine. 2018 Jan;46(1):28.
- B. Achuff, J. Achuff, H. Park, B. Moffett, S. Acosta, C. Rusin, P. Checchia "Epinephrine syringe exchange events in a paediatric cardiovascular ICU: analysing the storm." Cardiology in the Young. 2017 Dec;1-7.
- S. Acosta and V. Villamizar "Coupling of Dirichlet-to-Neumann boundary condition and finite difference methods in curvilinear coordinates for multiple scattering." J. Comput. Phys.. 2010;229:5498–5517.
- B-J. Achuff, B. Moffett, S. Acosta, J. Lasa, P. Checchia, C. Rusin "Hypotensive response to IV Acetaminophen in pediatric cardiac patients." Pediatr. Crit. Care Med.. 2019 Jan; Pubmed PMID: 30676493
- S. Acosta, B. Palacios "Thermoacoustic tomography using an integro-differential wave equation modeling attenuation." J. Diff. Equations. 2018;264:1984-2010.
- C. Puelz, S. Acosta, B. Riviere, D. Penny, K. Brady, C. Rusin "A computational study of the Fontan circulation with fenestration or hepatic vein exclusion." Computers in Biology and Medicine. 2017;89:405-418.
- V. Villamizar, S. Acosta, B. Dastrup "High order local absorbing boundary conditions for acoustic waves in terms of farfield expansions." J. Comput. Phys.. 2017;333:331-351.
- S. Acosta and V. Villamizar "Generation of smooth grids with line control for scattering from multiple obstacles." Math. Comput. Simul.. 2009;79:2506-2520.
- S. Acosta and V. Villamizar "Finite differences on grids with nearly uniform cell area and line spacing for the wave equation on complex domains." J. Comp. Appl. Math.. 2010;234:1970-1979.
- S. Acosta and V. Villamizar "Elliptic grids with nearly uniform cell area and line spacing." Elect. Trans. Num. Anal. ETNA.. 2009;34:59-75.
- S. Acosta and P. Acosta "Numerical wave scattering taking account of energy dissipation and media stiffness." SIAM J. Undergrad. Research Online.. 2008;1:100-119.
- S. Acosta "Recovery of pressure and wave speed for photoacoustic imaging under a condition of relative uncertainty." Inverse Problems. 2019;35(11):115013.
- S Acosta "Well-posedness for photoacoustic tomography with Fabry-Perot sensors." SIAM J. Imag. Sciences. 2019;12(4):1669-1685.
- D. Rios, C. Rhee, L. Elizondo, K. Brady, C. Rusin, S. Acosta "Creatinine filtration kinetics in critically ill neonates." Pediatric Research. 2020 May 26;
- M. Ahmed et al. "Multisystem inflammatory syndrome in children: A systematic review." EClinicalMedicine. 2020 Sep;26:100527.
- Antonio Mendoza, Sebastian Tume, Kriti Puri, Sebastian Acosta, Joseph R Cavallaro "Clinical Features and Physiological Signals Fusion Network for Mechanical Circulatory Support Need Prediction in Pediatric Cardiac Intensive Care Unit." IEEE Journal of Biomedical and Health Informatics. 2024 Dec 2;
- Bryan G McOmber, Alvaro G Moreira, Kelsey Kirkman, Sebastian Acosta, Craig Rusin, Binoy Shivanna "Predictive analytics in bronchopulmonary dysplasia: past, present, and future." Front. Pediatr. 2024 Nov 19;12
- Julia Weld, Erin Kim, Priya Chandra, Fabio Savorgnan, Sebastian Acosta, Saul Flores, Rohit S Loomba "Fluid Overload and AKI After the Norwood Operation: The Correlation and Characterization of Routine Clinical Markers." 2023 May 2;45:1440–1447.
- Rohit S Loomba, Fabio Savorgnan, Sebastian Acosta, Justin J Elhoff, Juan S Farias, Enrique G Villarreal, Saul Flores "Clinical Interventions and Hemodynamic Monitoring in the Setting of Left Ventricular Systolic Heart Failure in Children: Insights From a Physiologic Simulator." American journal of therapeutics. 2024 Oct 1;31(5):e531-e540.
- Sebastian Acosta, Jesse Chan, Raven Johnson, Benjamin Palacios "Pseudodifferential models for ultrasound waves with fractional attenuation." SIAM Journal on Applied Mathematics. 2024 Aug 31;84(4):1609-1630.
- Rohit S Loomba, Umesh Dyamenahalli, Fabio Savorgnan, Sebastian Acosta, Enrique Villarreal, Juan S Farias, Joshua Wong, Saul Flores "Association of immediate postoperative hemodynamic and laboratory values in predicting Norwood admission outcomes." Pediatric Cardiology. 2022 Nov 9;45(6):1232-1241.
- Samantha Gilg, Sebastian Acosta, Rohit S Loomba, Claire Rizk, Gary E Stapleton, David Faraoni, Fabio Savorgnan "Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates." Pediatr Investig. 2024 Jul 20;8:135-138.
- Justin J Elhoff, Sebastian Acosta, Saul Flores, Julie LaSalle, Rohit Loomba, Molly McGetrick, Christy McKinney, Megan Ostrom, Chetna K Pande, Robin Schlosser, Sarah Schwab, Fabio Savorgnan "Parental holding of infants improves haemodynamics in the cardiac ICU." Cardiology in the Young. 2024 May 1;34(5):1004 - 1009.
- Sebastian Acosta, Tahsin Khajah "Method of virtual sources using on-surface radiation conditions for the Helmholtz equation." Engineering Analysis with Boundary Elements. 2024 Feb 1;159:342-351.
- Sebastian Acosta, Adel M Hassan, Zbigniew Gugala, Zena Karagoli, Jessica Hochstetler, Amy L Kiskaddon, Paul Checchia, David Faraoni, Feng Zheng, Fabio Savorgnan "Higher cumulative dose of opioids and other sedatives are associated with extubation failure in norwood patients." Pediatric Cardiology. 2023 Oct 25;45:8–13.
- Rohit S Loomba, Umesh Dyamenahalli, Fabio Savorgnan, Sebastian Acosta, Justin J Elhoff, Juan S Farias, Enrique Villarreal, Saul Flores "The effect of clinical and haemodynamic variables on post-operative length of stay immediately upon admission after biventricular repair with Yasui operation." Cardiology in the Young. 2023 Oct 1;33(10):2066-2071.
- Craig G Rusin, Sebastian I Acosta, Kennith M Brady, Eric Vu, Carly Scahill, Brian Fonseca, Cindy Barrett, Janet Simsic, Andrew R Yates, Brenna Klepczynski, William J Gaynor, Daniel J Penny "Automated prediction of cardiorespiratory deterioration in patients with single-ventricle parallel circulation: A multicenter validation study." JTCVS open. 2023 Sep 1;15:406-411.
- Fabio Savorgnan, Daniel I Crouthamel, Andy Heroy, John Santerre, Sebastian Acosta "Markov model for detection of ECG instability prior to cardiac arrest in single-ventricle patients." Journal of Electrocardiology. 2023 Sep 1;80:106-110.
- Sebastian Acosta, Tahsin Khajah, Benjamin Palacios "A new interpolated pseudodifferential preconditioner for the Helmholtz equation in heterogeneous media." SIAM J Sci Comput. 2025;
- Devika Subramanian, Aadith Vittala, Xinpu Chen, Christopher Julien, Sebastian Acosta, Craig Rusin, Carl Allen, Nicholas Rider, Zbigniew Starosolski, Ananth Annapragada, Sridevi Devaraj "Stratification of pediatric COVID-19 cases using inflammatory biomarker profiling and machine learning." Journal of Clinical Medicine. 2023 Aug 22;12(7):5435.
- Howard Chao, Sebastian Acosta, Craig Rusin, Christopher Rhee "Comparison of near-infrared spectroscopy-based cerebral autoregulatory indices in extremely low birth weight infants." Children. 2023 Jul 9;10(8):1361.
- Juan S Farias, Enrique G Villarreal, Fabio Savorgnan, Sebastian Acosta, Saul Flores, Rohit S Loomba "The use of neutrophil–lymphocyte ratio for the prediction of refractory disease and coronary artery lesions in patients with Kawasaki disease." Cardiology in the Young. 2023 Aug 1;33(8):1409-1417.
- Mubbasheer Ahmed, Sebastian I Acosta, George M Hoffman, James S Tweddell, Nancy S Ghanayem "Mathematical analysis of hemoglobin target in univentricular parallel circulation." The Journal of Thoracic and Cardiovascular Surgery. 2023 Jul 1;166(1):214-220.
- Sebastian Acosta, Srinivasan Suresh, Anna K Ettinger, Fabio Savorgnan, Ananth Annapragada, Nirupama Kannikeswaran, Usha Sethuraman "Association of area deprivation index with severity of COVID-19 in pediatric patients: A multisite study of racially and ethnically diverse children." The Pediatric Infectious Disease Journal. 2023 Jun 1;42(6):e197-e200.
- Leah I Elizondo, Danielle R Rios, Eric Vu, Kathleen Kibler, R Blaine Easley, Dean B Andropoulos, Sebastian Acosta, Craig G Rusin, Jeffrey R Kaiser, Ken M Brady, Christopher J Rhee "Observed and calculated cerebral critical closing pressure are highly correlated in preterm infants." Pediatric research. 2019 Aug 1;86(2):242-246.
- Sebastián Acosta, Carlos Montalto "Photoacoustic imaging taking into account thermodynamic attenuation." Inverse Problems. 2016 Sep 19;32(11):115001.
Memberships
- AHA: American Heart Association
- SIAM: Society for Industrial and Applied Mathematics
- US Association for Computational Mechanics
Funding
- Collaborative Research: Improved Algorithms for Multiwave Imaging in Complex Media: Theory and Computation - #1712725 (07/15/2017 - 06/30/2020) Grant funding from NSF-DMS
- Novel pseudo-differential methods to drastically increase computational speed and accuracy for biomedical ultrasound imaging and focusing - #1R15EB035359-01A1 Grant funding from NIH
- The PreVAIL-kIds Common Protocol - #4R33HD105593 Grant funding from NIH
Intellectual Property
- Method Patent #11504015 (Approved)
- A technique for predicting fluid responsiveness in a critically ill patient comprises measuring physiological data of the patient, then generating an estimate of pulse pressure vari ability from a Fourier transform of the physiological wave form. Both invasive and non-invasive physiological data measurements may be used.
- Co Inventors: Sebastian Acosta, Mubbasheer Ahmed, Suellen Yin, Kenneth M Brady, Daniel J Penny, Craig Rusin
- Method Patent #10485486 (Approved)
- A system generates and displays a clinical metric based on continuously collected patient physiological data, wherein the clinical metric provides a predictive measure of the likelihood of the onset of a cardiorespiratory deterioration event in the patient in a predetermined time period in the future. If the clinical metric has a configured relationship with a predetermined threshold value, embodiments may generate an alarm in addition to or instead of displaying the clinical metric. The clinical metric thus allows clinical staff to take medically indicated actions to prevent or reduce the effects of the predicted deterioration.
- Co Inventors: Craig Rusin, Kenneth M Brady, Eric Vu, Sebastian Acosta, Daniel J Penny
Languages
Spanish
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