Rachel N. Arey, Ph.D.
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Rachel N. Arey, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Department of Molecular and Cellular Biology
Center for Precision Environmental Health
Baylor College of Medicine
Houston, Texas United States
Addresses
- Alkek Building (Office) (Office)
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Alkek Building
Room: N1317.02
Houston, TX 77030
United States
Phone: (713) 798-2955
rachel.arey@bcm.edu
Education
- BA from Austin College
- Sherman, TX
- PhD from University of Texas Southwestern Medical Center
- Dallas, TX
- Neuroscience
- Postdoctoral Fellowship at Princeton University
- Princeton, NJ
- Cognitive Aging, Genetics and Genomics
Professional Interests
- Cognitive Aging
- Learning and Memory
- C. elegans genetics and genomics
- Molecular underpinnings of complex behavior
Professional Statement
Research in the Arey lab focuses on identifying novel and conserved regulators of learning and memory, with a particular focus on cognitive aging. We use an interdisciplinary approach, combining C. elegans genetics and genomics tools along with microscopy and behavioral assays. We are particularly interested in how changes in synaptic function and transmission contribute to age-related memory loss, and finding pathways that prevent cognitive decline.Selected Publications
- Arey RN, Kaletsky R, Murphy CT. "Nervous System-Wide Profiling of Presynaptic mRNAs Reveals Regulators of Associative Memory." Sci Reports. 2019 Dec 30;9(1):20314. Pubmed PMID: 31889133
- Arey RN, Stein GM, Kaletsky R, Kauffman A, Murphy CT. "Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline.." Neuron. 2018 May 2;98(3):562-574. Pubmed PMID: 29656871
- Lakhina V*, Arey RN*, Kaletsky R*, Kauffman A,* Stein G, Keyes W, Xu D, Murphy CT. "Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs.." Neuron. 2015 Jan 21;85(2):330-45. Pubmed PMID: 25611510
- Kaletsky R*, Lakhina V*, Arey R, Williams A, Landis J, Ashraf J, Murphy CT. "The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.." Nature. 2016 Jan 7;529(7584):92-6. Pubmed PMID: 26675724
- Li LB, Lei H, Arey RN, Li P, Liu J, Murphy CT, Xu XZ, Shen K. "The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory.." Curr Biol.. 2016 Mar 7;26(5):605-15. Pubmed PMID: 26877087
- Arey RN, Murphy CT. "Conserved regulators of cognitive aging: From worms to humans.." Behav Brain Res.. 2017 Mar 30;322(Pt B):299-310. Pubmed PMID: 27329151
- Arey RN, Enwright JF 3rd, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA. "An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.." Mol Psychiatry.. 2014 Mar;19(3):342-50. Pubmed PMID: 23399917
- Arey R, McClung CA. "An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse.." Behav Pharmacol.. 2012 Aug;23(4):392-6. Pubmed PMID: 22743604
Memberships
- Society For Neuroscience
Funding
- Defining the Essential Long-term memory translatome Whitehall Foundation
- Identifying Neuropeptide Signals that Slow Cognitive Aging Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty
- Uncovering brain-wide molecular determinants of individual memory performance across lifespan NIH Director's New Innovator Award
- Identifying behavioral and molecular effects of perfluorinated compounds on cognitive aging GC-CPEH NIEHS Center Pilot Project
- Junior Faculty Seed Grant ( Caroline Wiess Law Fund For Research in Molecular Medicine
- Profiling how age-related changes in presynaptic mRNA localization and levels contribute to cognitive decline.
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