Email

pavan.reddy@bcm.edu

Positions

Director

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Senior Associate Dean, Cancer Programs

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Professor

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Education

MD from Osmania University

Hyderabad, India

Residency at University of Missouri

Columbia, Missouri United States

Internal Medicine

Fellowship at University of Michigan

Ann Arbor, Michigan United States

Hematology/Oncology, Bone and Marrow Transplantation

Certifications

Internal Medicine

American Board of Internal Medicine

Medical Oncology

American Board of Internal Medicine

Honors & Awards

Presidential Lecture

City of Hope Cancer Center (01/2022 - 12/2022)

Fellow

American Society of Transplantation and Cell Therapy (01/2022 - 12/2022)

President

American Society of Transplantation and Cell Therapy (01/2020 - 12/2021)

Section Editor

Current Opinion in Hematology (01/2019 - 12/2024)

Section Editor

Frontiers in Immunology (01/2019 - 12/2022)

Deputy Editor

JCI Insight (01/2019 - 12/2024)

President Elect

American Society of Transplantation and Cell Therapy (01/2019 - 12/2020)

Vice-President

American Society of Blood and Marrow Transplantation (01/2018 - 12/2019)

Chair

ASH Awards Review Subcommittee (01/2017 - 12/2021)

Professional Interests

• Immunobiology of GVHD
• Development of GVHD

Professional Statement

Dr. Pavan Reddy has a long-standing interest in cellular molecular immunology, metabolism, in vivo animal models, human sample analysis and clinical hematopoietic cell transplantation (HCT) for blood diseases. His lab has contributed to the fundamental understanding of immunology, the biology of graft-versus-host disease, and has successfully translated laboratory observations into proof-of-concept human trials following HCT. His work provided seminal insights into the role of target tissue resilience in mitigating GVHD, the role of non-coding RNAs and intracellular trafficking mechanisms in T cells and led to clinical translation of five distinct and novel approaches in prevention and treatment of GVHD, which are now being studied in randomized national trials. His research has been funded for over a decade with multiple NIH and other peer reviewed grants. As the director of the Dan L Duncan Comprehensive Cancer Center, his major focus has been on promoting access, community engagement, and transdisciplinary research.

Selected Publications

• 1. Badr H, Rouce R, Scheurer ME, Lulla P, Mims M, Reddy P "Bringing CAR T cell therapy trials to underserved populations.." Cancer Cell. 2023 Dec 11;41(12):2007-2010. Pubmed PMID: 37890490
• 2. Riwes MM, Golob JL, Magenau J, Shan M, Dick G, Braun T, Schmidt TM, Pawarode A, Anand S, Ghosh M, Maciejewski J, King D, Choi S, Yanik G, Geer M, Hillman E, Lyssiotis CA, Tewari M, Reddy P "Feasibility of a dietary intervention to modify gut microbial metabolism in patients with hematopoietic stem cell transplantation." Nature Medicine. 2023 Nov;29(11):2805-2813. Pubmed PMID: 10667101
• 3. Fujiwara H, Seike K, Brooks MD, Mathew AV, Kovalenko I, Pal A, Lee HJ, Peltier D, Kim S, Liu C, Oravecz-Wilson K, Li L, Sun Y, Byun J, Maeda Y, Wicha M, Saunders T, Rehemtulla A, Lyssiotis CA, Pennathur S, Reddy P "Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated Immunopathology." Nature Immunology. 2021 Nov;22(11):1440-1451. Pubmed PMID: 1804356
• Mathewson N, Jenq R, Mathew AV, Koenigsknecht M, Hanash A, Toubai T, Oravecz-Wilson K, Wu SR, Sun Y, Rossi C, Fujiwara H, Byun J, Lindemans C, Calafiore M, Schmidt TC, Honda K, Young VB, Pennathur S, Brink MVD, Reddy P "Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease." Nature Immunology. 2016 May;17(5):505-13. Pubmed PMID: 4836986