Positions
- Professor
-
Virol & Micro: Ling
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Education
- Postdoctoral Fellowship at Johns Hopkins University School Of Medicine
- Baltimore, MD United States
- PhD from USUHS F. Edward Hebert School Of Medicine
- Bethesda, MD United States
- BA from St. Olaf College
- Northfield, Minnesota United States
Honors & Awards
- Graduated Cum Laude
- St. Olaf College
- National Research Service Award for individual postdoctoral fellows
- Leukemia Society of America Special Fellow Award
- Secretary
- Epstein-Barr Virus Association (01/2006 - 01/2013)
- Certificate of Appreciation
- Elephant Managers Association (EMA)
- Associate Editor
- PLOS Pathogens
- Member
- American Cancer Society peer review group (Microbial Pathogenesis and Cancer; MPC) 2010-2015
- Chair
- American Cancer Society peer review group (Microbial Pathogenesis and Cancer; MPC) 2013-2015
- Executive committee EEHV Advisory Group
- EEHV Advisory group
Professional Interests
- Elephant Endotheliotropic Herpesvirus (EEHV)
- Gammaherpesvirus pathogenesis
Professional Statement
The Ling laboratory investigates herpesviruses in humans and animals, with a focus over the last 10 years on Elephant Endotheliotropic Herpesvirus (EEHV). EEHV can cause lethal hemorrhagic disease, particularly in juvenile Asian elephants. It is the leading cause of death in juvenile Asian elephants in North America and Europe and also affects both free-roaming and captive Asian elephants in their natural range countries. To address this problem, our laboratory, in close partnership with the Houston Zoo, has developed a comprehensive “Bench to Barn” research program focusing on 1) diagnostics, 2) treatments, and long-term 3) a vaccine. Progress towards these goals has been made through the development of qPCR diagnostic assays, sequencing the EEHV genome, and developing tools to measure and evaluate elephant immune responses to EEHV. Trials evaluating a prototype vaccine against EEHV1A, the EEHV type associated with most disease in Asian elephants, have recently been initiated. Postdoctoral fellows and students who participate in this research develop skills applicable to research and vaccine development for any viral pathogen that infects humans or animals.Websites
Information site for all things EEHV
Selected Publications
- Cook, K.A., Ling, P.D., Terio, K.A., Baumgartner, W.A., Howard, L.L., and Landolfi, J.A. 2023. "Detection of Elephant Endotheliotropic Herpesvirus (EEHV) 1A in archival tissue using RNASCOPE In situ hybridization.." J Zoo Wildl Med. 2023;53:661-669. Pubmed PMID: 36640067
- Watts, J., Clinton, J.L.S., Pollet, J., Peng R.S., Tan, J., and P.D. Ling. "Multi-Antigen Elephant Endotheliotropic Herpesvirus (EEHV) mRNA Vaccine Induces Humoral and Cell-Mediated Responses in Mice." Vaccines (Basel). 2024 Dec;12:1429. Pubmed PMID: 39772089
- Clinton, J.L.C., Hoornweg, T., Tan, J., Peng, RS., Schaftenaar, W., Rutten, V. P., de Haan, C.A.M., and PD Ling "The EEHV1A gH/gL complex elicits humoral and cell-mediated immune responses in mice." Vaccine. 2024 Aug;42:126227. Pubmed PMID: 39180978
- Clinton, J.L.C., Hoornweg, T., Tan, J., Peng, RS., Schaftenaar, W., Rutten, V. P., de Haan, C.A.M., and PD Ling "EEHV1A glycoprotein B subunit vaccine elicits humoral and cell-mediated immune responses in mice." Vaccine. 2022 Aug;40:5131-5140. Pubmed PMID: 35879117
- Iyer, M.L., Molter, C.M., Flanagan, J.P., Bauer, K.L., Marrow, J., Bernardy, R., Hoffman, D., Parkinson, L., Evans, T.S., and Paul D. Ling "Novel Diagnostic and Therapeutic approaches to elephant endotheliotropic herpesvirus 1A hemorrhagic disease in a captive juvenile Asian elephant.." J Zoo Wildl Med .. 2022 Mar;53:232-240. Pubmed PMID: 35339171
Memberships
- American Society for Virology
- Member
- American Society for Microbiology
- Member
- Elephant Endotheliotropic Herpesvirus (EEHV) Advisory Committee
- Member
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