Nicholas Murphy, PhD
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Nicholas Murphy, PhD
Assistant Professor
Positions
- Assistant Professor
-
Menninger Department of Psychiatry and Behavioral Sciences
Neuropsychiatry
Baylor College of Medicine
Houston, Texas
Education
- Postdoctoral Fellowship at University of Texas Health Science Center at Houston
- Houston, Texas United States
- Neuropsychiatry
- Postdoctoral Training at Newcastle University
- Newcastle Upon Tyne, United Kingdom
- Neuroscience, Neuropsychiatry
- PhD from Newcastle University
- 03/2016 - Newcastle upon Tyne, United Kingdom
- MSc from The University of York
- 01/2013 - York, United Kingdom
- BSc from Bangor University
- 08/2011 - Bangor, United Kingdom
- Postdoctoral Fellowship at Baylor College of Medicine
- Houston, Texas
- Neuropsychiatry
Websites
Selected Publications
- Nicholas Murphy; Nithya Ramakrishnan; Christopher P. Walker; Nicola R. Polizzotto;Raymond Y. Cho "). Intact Auditory Cortical Cross-Frequency Coupling in Early and Chronic Schizophrenia." Frontiers in Psychiatry. 2020;
- Aadith Vittala; Nicholas Murphy; Atul Maheshwari; Vaishnav Krishnan "Understanding Cortical Dysfunction in Schizophrenia with TMS/EEG." Front. Neurosci. 2020;
- Nithya Ramakrishnan; Nicholas Murphy; Christopher Walker; Valeria Cuellar Leal; Jair Soares; Raymond Cho; Sudhakar Selvaraj "Neurophysiological Effect of Ketamine on Prefrontal Cortex in Treatment Resistant Depression: A combined TMS-EEG study." Chronic Stress. 2019;
- Firbank, M.J*., Parikh, J*., Murphy, N.R.E., Killen, A., Allan, C., Collerton, D., Blamire, A., Taylor, J.P. "Reduced occipital GABA+ and white matter integrity in Parkinson’s disease dementia with visual hallucinations." Neurology. 2018; Pubmed PMID: 30021920
- Stylianou, M., Murphy, N.R.E., Peraza, L.R., Graziadio, S., Cromarty, R., Killen, A., O’Brien, J., Thomas, A., LeBeau, F., Taylor, J.P. "Quantitative electroencephalography (QEEG) as a marker of cognitive fluctuations in dementia with Lewy bodies (DLB) and aid to differential diagnosis." Clin Neurophysiol. 2018; Pubmed PMID: 29656189
- Walker, C.P.*, Pessoa, A.L.S.*, Figueiredo, T.*, Rafferty, M., Melo, U.S., Nóbrega, P.R., Murphy, N.R.E, Kok, F., Zatz, M., Santos, S., Cho, R.Y. "Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG." 2019;
- Davey, J., Rueschemeyer, S.A., Costigan, A., Murphy, N.R.E., Krieger-Redwood, K., Hallam, G., Jefferies, B. "Shared neural processes support semantic control and action understanding,." Brain Lang. 2015; Pubmed PMID: 25658631
- Nicholas Murphy, Nithya Ramakrishnan, Bylinda Vo-Le, Brittany Vo-Le, Mark A. Smith, Tabish Iqbal, Alan C. Swann, Sanjay J. Mathew & Marijn Lijffijt "A randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-D-aspartate receptor blockade in healthy veterans." Neuropsychopharmacology. 2020 Dec; Pubmed PMID: 33318635
- O'Brien B, Lijffijt M, Lee J, Kim YS, Wells A, Murphy N, Ramakrishnan N, Swann AC, Mathew SJ. "Distinct trajectories of antidepressant response to intravenous ketamine." J Affect Disord. 2021 May 1; Pubmed PMID: 33770540
- Murphy N, Lijffijt M, Ramakrishnan N, Vo-Le B, Vo-Le B, Iqbal S, Iqbal T, O'Brien B, Smith MA, Swann AC, Mathew SJ. "Does mismatch negativity have utility for NMDA receptor drug development in depression?." Braz J Psychiatry. 2021 Apr 5; Pubmed PMID: 33825765
- Murphy N, Killen A, Graziadio S, Rochester L, Firbank M, Allan C, Collerton D, Taylor J, Urwyler P. "Exploring Bottom-Up Visual Processing and Visual Hallucinations in Parkinson's Disease with Dementia.." Frontiers Neurology. 2021;
- Ramakrishnan.N, Lijffijt.M, Green.C, Balderston.B, Murphy.N, Grillon.C, Iqbal.T, Vo-Le.B, O’Brien.B, Murrough.J, Swann.A, Mathew.SJ. "Neurophysiological and clinical effects of the NMDA receptor antagonist lanicemine (BHV-5500) in PTSD: A randomized, double-blind, placebo-controlled trial." Depress Anxiety. 2021 Jul 12; Pubmed PMID: 34254405
- Murphy, N. "Chapter 6: Constructing and Accessing Meaning at the Cortical Level an Investigation of the Neural Networks Underpinning Semantic Cognition, Focusing on the Representation of Action and Vision. In, Meaning and Logos." 2015;
- Murphy, N.R.E., Graziadio, S., & Taylor, JP. "Chapter 8: EEG and transcranial magnetic stimulation. Changing and recording the dynamic flow of visual perception. In, The Neuroscience of Visual Hallucinations." 2015;
- Nicholas Murphy, PhD "Neurophysiological Biomarkers as a Springboard for the Refinement of Transcranial Magnetic Stimulation Therapy: Stratification, Mechanisms of Action, and Next Steps." Biological Psychiatry. 2023 Sep 15;94(6):443-444.
Memberships
- American Society of Clinical Psychopharmacology
- Anxiety and Depression Association of America
Funding
- A Pilot Study to Determine the Safety, Tolerability, and Feasibility of Imaging AMPA Receptors in PTSD (07/01/2022 - 06/30/2023) Grant funding from Caroline Wiess Law Fund for Research in Molecular Medicine
- Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression - #1R21MH133198-01A1 (01/01/2024 - 12/31/2025) Grant funding from NIMH
- In this study we utilize a mechanistic clinical trial approach to evaluate the utility of ketamine induced gamma band potentiation to predict ketamine therapy clinical outcomes.
- Behavioral Sensitization Underlying Misophonia and its Illness Course (01/01/2022 - 12/31/2023) Grant funding from The REAM Foundation - Misophonia Research Fund
- In this study we examine behavioral sensitization using potentiated startle as a possible biological mechanism involved in misophonia and its illness course.
Skills
- Electroencephalography (EEG)
- Magnetoencephalography (MEG)
- Neuromodulation
- Use of magnetic and electrical stimulation for clinical and research purposes.
- Neurophysiology
- Matlab
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