Email

mkarlsso@bcm.edu

Positions

Clinical Informatics Fellow - PGY7

Pathology
Baylor College of Medicine
Houston, Texas United States

Education

BS from University of California Los Angeles

07/2007 - Los Angeles, California United States

Neuroscience (Major), Physiological Science (Major)

PhD from University of Alabama at Birmingham

07/2016 - Birmingham, Alabama United States

Neurobiology

MD from University of Alabama at Birmingham

06/2018 - Birmingham, Alabama United States

Medical Scientist Training Program

Residency at Baylor College of Medicine

06/2024 - Houston, Texas United States

Neurodevelopmental Disabilities

Certifications

#V3011

Texas Medical Board

Honors & Awards

President’s Diversity Champion Award

Award recognizes individuals and organizations significantly contributing to creating a more culturally diverse and inclusive university community.

University of Alabama at Birmingham (02/2018)

David C. Leach Award

This award recognizes residents and fellows who have fostered innovation and improvement in their programs, advanced humanism in medicine, and increased efficiency and emphasis on educational outcomes.

Accreditation Council for Graduate Medical Education (10/2024)

Professional Statement

As a pediatric neurologist specializing in neurodevelopmental disabilities and currently in a clinical informatics fellowship, I am deeply passionate about pediatric medicine and neuroscience.

In my practice, I focus on pediatric patients with Mendelian disorders of the epigenetic machinery. I aim to leverage informatics-based approaches, including electronic health records, clinical decision support systems, health information exchanges, and predictive analytics, to improve diagnoses and personalize healthcare interventions for children with complex neurological conditions.

Additionally, I am committed to promoting diversity, equity, and inclusion in patient care and graduate medical education, striving to improve healthcare outcomes for underrepresented communities.

Websites

Selected Publications

• Meadows, J.P.*, Guzman-Karlsson, M.C.*, Phillips S., Brown, J.A., Strange, S.K., Sweatt, J.D., Hablitz, J.J. "DNA Methylation Regulates Neuronal Intrinsic Membrane Excitability." Sci. Signal.. 2016 Aug 23;9(442):ra83. Pubmed PMID: 27555660
• Kennedy, AJ, Rahn, EJ, Paulukaitis, BS, Savell, KE, Kordasiewicz, HB, Wang, J, Lewis, JW, Posey, J, Strange, SK, Guzman-Karlsson, MC, Phillips, SE, Decker, K, Motley, SM, Swayze, EE, Ecker, DJ, Michael, TP, Day, JJ, Sweatt, JD "Tcf4 regulates synaptic plasticity, DNA methylation, and memory function." Cell Rep.. 2016 Sep 6;16(10):2666-2685. Pubmed PMID: 27568567
• Jarrod P. Meadows, Mikael C. Guzman-Karlsson, Scott Phillips, Christopher Holeman, Jessica L. Posey, Jeremy J. Day, John J. Hablitz, J. David Sweatt "DNA methylation regulates neuronal glutamatergic synaptic scaling." Sci. Signal.. 2015 Jun 23;8(382):ra61. Pubmed PMID: 26106219
• Rafał Czajkowski, Balaji Jayaprakash, Brian J. Wiltgen, Thomas Rogerson, Mikael C. Guzman-Karlsson, Alison Barth, Joshua Trachtenberg, Alcino J. Silva "Encoding and storage of spatial information in the retrosplenial cortex." Proc. Natl. Acad. Sci. U.S.A.. 2014 Jun 10;111(23):8661-8666. Pubmed PMID: 24912150

Memberships

American Academy of Neurology

American Medical Informatics Association

Child Neurology Society

Associate Chair of Leadership, Diversity, Equity, and Inclusion Committee

American Academy of Pediatrics

Member of Council on Children with Disabilities (COCWD) Equity, Diversity, and Inclusion Subcommittee

American Neurological Association

Texas Pediatric Society

Texas Neurological Society

Funding

Enhancing SDOH Screening and Counseling in Pediatric Neurology: A Mixed-Methods Study

Grant funding from American Academy of Pediatrics - Section of Pediatric Trainees

Inspiring Minds: Brain Fair and Beyond

Grant funding from American Academy of Pediatrics (AAP) Section on Early Career Physicians (SOECP)

Languages

Spanish