Email

mihail.chelu@bcm.edu

Positions

Professor

Medicine - Cardiology
Baylor College of Medicine
Houston, Texas United States

Director of Electrophysiology

Baylor College of Medicine
Houston, Texas United States

Director of Clinical Electrophysiology Research

Baylor College of Medicine
Houston, Texas United States

Medical Director

Inherited Arrhythmia and Cardiomyopathy Clinic
Baylor College of Medicine
Houston, Texas United States

Associate Program Director

Electrophysiology Fellowship
Baylor College of Medicine

Addresses

Fannin Tower - Cardiology (Clinic)

6624 Fannin Street, Ste. 2480
Houston, TX 77030
United States
Phone: (713) 529-5530
https://hgcardio.com/

Education

MD from Iuliu Hatieganu University of Medicine and Pharmacy

09/2000 - Cluj-Napoca, Romania

PhD from Baylor College of Medicine

09/2006 - Houston, Texas United States

Molecular Physiology and Biophysics

Clinical Fellowship at Texas Heart Institute at St Luke's Episcopal Hospital/Baylor College of Medicine

06/2013 - Houston, Texas United States

Cardiac Electrophysiology

Clinical Fellowship at Texas Heart Institute at St Luke's Episcopal Hospital/Baylor College of Medicine

06/2012 - Houston, Texas United States

Cardiovascular Disease

Postdoctoral Fellowship at Baylor College of Medicine

03/2009 - Houston, Texas United States

Internal Medicine/Clinical Investigator Pathway

Residency at University of Texas Health Science Center

03/2009 - Houston, Texas United States

Internal Medicine/Clinical Investigator Pathway

Internship at University of Texas Health Science Center

03/2006 - Houston, Texas United States

Internal Medicine

MS from Babes-Bolyai University

06/1997 - Cluj-Napoca, Romania

Theoretical Physics

BS from Babes-Bolyai University

06/1996 - Cluj-Napoca, Romania

Physics

Certifications

Clinical Cardiac Electrophysiology

American Board of Internal Medicine

Cardiovascular Disease

American Board of Internal Medicine

Honors & Awards

Associate Fellow

American College of Cardiology

Professional Interests

• Clinical Cardiac Electrophysiology
• Inherited cardiac arrhythmias and cardiomyopathies
• Sudden cardiac death
• Ablation of complex atrial flutters and fibrillation
• Ablation of ventricular arrhythmias
• Implantation of pacemakers, defibrillators, cardiac resynchronization therapy devices
• Conduction system pacing

Professional Statement

Dr. Chelu’s research interests include:
1) molecular mechanisms and genetics of cardiac arrhythmias and cardiomyopathies;
2) clinical trials of devices and medications for treatment of arrhythmias;
3) outcomes research of interventions for treatment of cardiovascular diseases;
4) integration of sensors and mobile platforms to monitor, identify disease signatures, and determine impact on quality of life.

Websites

Selected Publications

• Kim JA, Kim SE, Ellenbogen KA, Vijayaraman P, Chelu MG. "Clinical outcomes of conduction system pacing versus biventricular pacing for cardiac resynchronization therapy: A systematic review and meta-analysis.." J Cardiovasc Electrophysiol.. 2023;34(8):1718-1729. Pubmed PMID: 37343033
• Haddadin F, Majmundar M, Jabri A, Pecha L, Scott C, Daher M, Kumar A, Kalra A, Fram R, Haddadin F, Almahameed S, DeSimone CV, Cha YM, Mulpuru SK, Ellenbogen KA, Saeed M, Chelu MG, Deshmukh AJ. "Clinical outcomes and predictors of complications in patients undergoing leadless pacemaker implantation.." Heart Rhythm.. 2022;19(8):1289-1296. Pubmed PMID: 35490710
• Kim JA, Khan K, Kherallah R, Khan S, Kamat I, Ulhaq O, Marashly Q, Chelu MG. "Innovations in atrial fibrillation ablation.." J Interv Card Electrophysiol.. 2022;66(3):737-756. Pubmed PMID: 35411440
• Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH "Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice." J Clin Invest. 2009 Jul;119(7):1940-51. Pubmed PMID: 19603549

Funding

Left vs Left RCT - #PLACER 2021C3- 24160

$30,777,361.00 (01/01/2023 - 06/30/2029)

Patient-Centered Outcomes Research Institute (PCORI)

Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing with a Left Ventricular Epicardial Lead in Patients with Heart Failure (HF) with Left Ventricular Ejection Fraction (LVEF) ≤ 50% and with either a Wide QRS Complex (> 130 ms) or with/anticipated > 40% Pacing Randomized Clinical Trial (RCT) (NCT05650658) The goal is test the comparative effectiveness of His/Left Bundle Branch Pacing in relation to patient centered outcomes (quality of life, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure with LVEF≤50% and an indication for cardiac resynchronization therapy by the current guidelines. The primary outcome is death from any cause or HF leading to hospitalization. The study is expected to enroll and randomize 2136 participants at 65 investigational sites in USA and Canada. The enrollment is ongoing with 469 participants randomized at 63 active sites as of April 10, 2025.

Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders - #1R01HL166832

(09/25/2024 - 06/30/2029) NIH/NHLBI