Michelle Masayo Kameda-Smith, MBChB, PhD, FRCS(C) Neurosurgery
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Michelle Masayo Kameda-Smith, MBChB, PhD, FRCS(C) Neurosurgery
Research Postdoctoral Fellow - MD in Functional Genomics
Positions
- Research Postdoctoral Fellow - MD in Functional Genomics
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Pediatric Hematology-Oncology
Pediatric Neuro-Oncology
Baylor College of Medicine
Houston, Texas US
Addresses
- Laboratory of Dr. Michael Taylor (Lab)
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Texas Children's Hospital
Feigin Tower
Houston, TX 77030
United States
Education
- BSc from University of Waterloo
- 07/2002 - Waterloo, Ontario Canada
- MSc from University of Western Ontario
- 08/2004 - London, Ontario Canada
- MBChB from University of Glasgow
- 07/2010 - Glasgow, Scotland United Kingdom
- PhD from McMaster University
- 05/2019 - Hamilton, Ontario Canada
- Residency at McMaster University
- 06/2022 - Hamilton, Ontario Canada
- Clinical Fellowship at Great Ormond Street Hospital for Children
- 07/2023 - London, England United Kingdom
Certifications
- Fellowship of the Royal College of Physicians and Surgeons of Canada (FRCSC) Neurosurgery
- Royal College of Physicians and Surgeons of Canada
Professional Interests
- Pediatric Neurosurgery
- Pediatric Neurooncology
Selected Publications
- Kameda-Smith MM, Zhu H, Luo EC et al "Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma." Nat Commun.. 2022 Dec 6;13(1):7506. Pubmed PMID: 36473869
- Visvanathan A, Saulnier O, Chen C, Haldipur P, Orisme W, Delaidelli A, Shin S, Millman J, Bryant A, Abeysundara N, Wu X, Hendrikse L… Kameda-Smith MM... Wechsler-Reya RJ, Weiss WA, Millen KJ, Ellison DW, Dimitrov DS, Taylor MD "Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma." Cell. 2024 Aug 22;187(22):4733-4750. Pubmed PMID: 38971152
- Badodi S, Dubuc A, Zhang X, Rosser G, Da Cunha Jaeger M, Kameda-Smith MM, Morrissy AS, Guilhamon P, Suetterlin P, Li XN, Guglielmi L, Merve A, Farooq H, Lupien M, Singh SK, Basson MA, Taylor MD, Marino S. "Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.." Cell Rep. 2017 Dec 5;21(10):2772-84. Pubmed PMID: 29212025
- Bakhshinyan D, Venugopal C, Adile AA, Garg N, Manoranjan B, Hallett R, Wang X, Mahendram S, Vora P, Vijayakumar T, Subapanditha M, Singh M, Kameda-Smith MM, Qazi M et al "BMI1 is a therapeutic target in recurrent medulloblastoma.." Oncogene. 2019 Mar;38(10):1702-16. Pubmed PMID: 30348991
- Wnt activation as a therapeutic strategy in medulloblastoma. Manoranjan B, Venugopal C, Bakhshinyan D, Adile AA, Richards L, Kameda-Smith MM, Whitley O, Dvorkin-Gheva A, Subapanditha M, Savage N, Tatari N, et al "Wnt activation as a therapeutic strategy in medulloblastoma.." Nat Commun.. 2020 Aug;11(1):4323. Pubmed PMID: 32859895
- Bakhshinyan D, Adile AA, Liu J, Gwynne WD, Suk Y, Custers S, Burns I, Singh M, McFarlane N, Subapanditha MK, Qazi MA, Vora P, Kameda-Smith MM, Savage N, Desmond KL, Tatari N, Tran D, Seyfrid M, Hope K, Bock NA, Venugopal C, Bader GD, Singh SK. "Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence." Sci Adv. 2021 Dec 10;7(50):eabi5568. Pubmed PMID: 34878832
- Kameda-Smith MM "Pediatric medulloblastoma in the molecular era: what are the surgical implications?." Cancer Metastasis Rev. 2020 Mar;39(1):235-43.
- Kameda-Smith MM, Ragulojan M, Elliott C, Bliss L, Moore H, Sader N, Alsuwaihel M, Tso MK, Dakson A, Ajani O, Yarascavitch B, Fleming A, Mehta V, Aminnejad M, Farrokhyar F, Singh SK; Canadian Neurosurgery Research Collaborative (CNRC). "National multicentered retrospective review of clinical and intraoperative factors associated with the development of cerebellar mutism after pediatric posterior fossa tumor resection.." Childs Nerv Syst.. 2024 Jan 27; Pubmed PMID: 38279985
- Kameda-Smith MM, Pond GR, Seow H. "Rurality index score and pediatric neuro-oncological outcome in Ontario.." J Neurosurg Pediatr.. 2023 Jan;275-81. Pubmed PMID: 36640100
- Adile AA, Bakhshinyan D, Suk Y, Uehling D, Saini M, Aman A, Magolan J, Subapanditha MK, McKenna D, Chokshi C, Savage N, Kameda-Smith MM, Venugopal C, Singh SK. "An effective kinase inhibition strategy for metastatic recurrent childhood medulloblastoma.." J Neurooncol.. 2023 Jul;163(3):635-45. Pubmed PMID: 37354357
- Sergeant A, Kameda-Smith MM, Manoranjan B, Karmur B, Duckworth J, Petrelli T, Savage K, Ajani O, Yarascavitch B, Samaan MC, Scheinemann K, Alyman C, Almenawer S, Farrokhyar F, Fleming AJ, Singh SK, Stein N. "Analysis of surgical and MRI factors associated with cerebellar mutism." J Neurooncol.. 2017 Jul;133(3):539-52. Pubmed PMID: 28527006
- Yang K, Nath S, Koziarz A, Badhiwala JH, Ghayur H, Sourour M, Catana D, Nassiri F, Alotaibi MB, Kameda-Smith M, Manoranjan B, Aref MH, Mansouri A, Singh S, Almenawer SA. "Biopsy Versus Subtotal Versus Gross Total Resection in Patients with Low-Grade Glioma: A Systematic Review and Meta-Analysis." World Neurosurg. 2018 Dec;120:e762-e775. Pubmed PMID: 30172972
- Kameda-Smith MM, Wang A, Abdulhadi N, Voth R, Sergeant A, Maharaj A, Bakhshinyan D, Adile AA, Pai AM, Ajani O, Yarascavitch B, Alyman MC, Duckworth J, Samaan MC, Farrokhyar F, Singh SK, Fleming A; Pediatric Brain Tumour Study Group. "Salvage Therapy for Childhood Medulloblastoma: A Single Center Experience.." Can J Neurol Sci.. 2019 Jul;46(4):403-14. Pubmed PMID: 31293232
- Kameda-Smith MM, White MA, St George EJ, Brown JI. "Time to diagnosis of paediatric posterior fossa tumours: an 11-year West of Scotland experience 2000-2011." Br J Neurosurg.. 2013 Jun;27(3):364-9. Pubmed PMID: 23186516
- Kameda-Smith MM, Zhang E, Lannon M, Algird A, Reddy K, Lu JQ. "Pituitary metastasis: From pathology to clinical and radiological considerations." J Clin Neurosci.. 2022 Nov;93:231-40. Pubmed PMID: 34656254
- Dakson A, Tso MK, Ahmed SU, Bigder M, Elliott C, Guha D, Lavergne P, Makarenko S, Iorio-Morin C, Kameda-Smith M, Taccone MS, Wang BH, Winkler-Schwartz A, Sankar T, Christie SD; Canadian Neurosurgery Research Collaborative. "Launch of the Canadian Neurosurgery Research Collaborative." Can J Neurol Sci.. 2017 Mar;44(2):204-6. Pubmed PMID: 28166852
- Lach B, Kameda-Smith M, Singh S, Ajani O. "Development of an Atypical Teratoid Rhabdoid Tumor in a Meningioma.." Int J Surg Pathol.. 2017 Sep;25(6):567-72. Pubmed PMID: 28459167
- Kameda-Smith MM, Jung Y, D'Arco F, Hewitt R, Aquilina K, Jeelani NUO. "Pediatric congenital anterior skull base encephaloceles and surgical management: A comparative review of 22 patients treated transnasally, transcranially, or combined approach with a review of the literature." Neurosurgery. 2024 Apr 29; Pubmed PMID: 38682945
- Kameda-Smith MM, Green K, Hutton DL, Jeelani NUO, Thompson DNP, Hargrave D, Aquilina K. "The role of reoperation in pediatric cerebellar pilocytic astrocytoma.." JNS Peds. 2024 May 17; Pubmed PMID: 38759245
Memberships
- Royal College of Physicians and Surgeons of Canada (RCPSC)
- Member (07/2022)
Funding
- Cancer Therapeutics and Training Program (CTTP) - #RP210043 (08/07/2023 Grant funding from Cancer Prevention and Research Institute of Texas (CPRIT)
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