Megumi Mathison, M.D., Ph.D.
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Positions
- Associate Professor of Surgery
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Division of Cardiothoracic Surgery
Baylor College of Medicine
Addresses
- Alkek Building for Biomedical Research (Office)
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Room: ABBR-411
Houston, TX 77030
United States
Education
- Residency from University of Tokyo School of Medicine
- ., Tokyo Japan
- Ph.D. from University of Tokyo
- ., Tokyo Japan
- M.D. from Tokyo Medical and Dental University
- ., Tokyo Japan
Professional Interests
- In situ cardiac regeneration
- Cardiovascular disease
- Cardiac cellular reprogramming
Professional Statement
In 2010, it was reported that a combination of three transcription factors— Gata4, Mef2c, and Tbx5— reprogrammed postnatal murine cardiac fibroblasts directly into differentiated cardiomyocyte-like cells in vitro. Recently, several researchers, including our group, reported that resident cardiac fibroblasts were reprogrammed into cardiomyocyte-like cells in the murine heart by direct injection of Gata4, Mef2c, Tbx5 into the myocardium after coronary ligation. These results raise the possibility that we can generate new cardiomyocytes from scar tissue after myocardial infarction in humans.Websites
Laboratory for Cardiac Regeneration
Selected Publications
- Mathison M, P Gersch R, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK "In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.." J Am Heart Assoc. 2012;1(6)
- Cui J, Li J, Mathison M, Tondato F, Mulkey SP, Micko C, Chronos NA, Robinson KA "A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials.." Cardiovasc Revasc Med. 2005;6(3):113-120.
- Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF "Extracellular matrix scaffold for cardiac repair.." Circulation. 2005;112
- Mathison MN, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Lima MM "Implications of problematic access in transluminal endografting of abdominal aortic aneurysm.." J Vasc Interv Radiol. 2003;14(1)
- Becker GJ, Kovacs M, Mathison MN "Transluminal repair of abdominal aortic aneurysm: a call for selective use, careful surveillance, new device design, and systematic study of transrenal fixation.." J Vasc Surg. 2002;35(3):611-615.
- Mathison M, Singh VP, Gersch RP, et al ""Triplet" Polycistronic Vectors Encoding Gata4, Mef2c, and Tbx5 Enhances Postinfarct Ventricular Functional Improvement Compared With Singlet Vectors." J Thorac Cardiovasc Sug. 2014 Oct;148(4):1656-1664. Pubmed PMID: 24755332
- Mathison M, Edgerton JR, Horswell L, et al. "Analysis of Hemodynamic Changes During Beating Heart Surgical Procedures." Ann Thorac Surg. 2000 Oct;70(4):1355-1360. Pubmed PMID: 11081898
- Mathison M, Singh VP, Chiuchiolo M, et al. "In Situ Reprogramming to Transdifferentiate Fibroblasts Into Cardiomyocytes Using Adenoviral Vectors: Implications for Clinical Myocardial Regeneration." J Thorac Cardiovasc Surg. 2017 Feb;153(2):329-339. Pubmed PMID: 27773576
- Mathison M, Singh VP, Sanagasetti D, et al. "Cardiac Reprogramming Factor Gata4 Reduces Postinfarct Cardiac Fibrosis Through Direct Repression of the Profibrotic Mediator Snail." J Thorac Cardiovasc Surg. 2017 Nov;154(5):1601-1610. Pubmed PMID: 28711329
- Mathison M, Rosengart TK "Heart Regeneration: The Endothelial Cell Comes First." J Thorac Cardiovasc Surg. 2018 Mar;155(3):1128-1129. Pubmed PMID: 29452462
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