Matthew Torre

Assistant Professor

Email

matthew.torre@bcm.edu

Positions

Assistant Professor: Pathology and Immunology
Baylor College of Medicine
Houston, Texas United States

Investigator: Jan and Dan Duncan Neurological Research Institute
Texas Children's Hospital

Faculty Member: Center for Alzheimer's and Neurodegenerative Diseases (CAND)
Baylor College of Medicine

Addresses

Duncan Neurological Research Institute (Lab)
: 1250 Moursund Street
DNRI-N.0650.28
Houston, TX 77030
United States

Education

MD from Harvard Medical School: Boston, Massachusetts United States

BA from University of Pennsylvania: Philadelphia, Pennsylvania United States

Residency at Brigham and Women's Hospital: Boston, Massachusetts United States; Anatomic Pathology

Clinical Fellowship at Brigham and Women's Hospital, Boston Children's Hospital: Boston, Massachusetts United States; Neuropathology

Postdoctoral Fellowship at Brigham and Women's Hospital: Boston, Massachusetts United States

Professional Interests

Chemotherapy-related cognitive impairment
Neurodegeneration
Iatrogenic neuropathology

Professional Statement

Chemotherapy-related cognitive impairment (CRCI) is an increasingly recognized adverse effect of treatment and is observed in up to 75% of patients. Despite the high frequency of CRCI and its associated patient morbidity, the pathophysiology of CRCI is incompletely understood. However, CRCI and neurodegenerative disorders such as Alzheimer's disease plausibly share biological mechanisms, and prior chemotherapy exposure may mediate future risk of dementia. The goal of the Torre laboratory is to dissect mechanisms contributing to CRCI and neurodegeneration and develop therapeutic strategies to preserve cognition in patients at risk of cognitive decline. The laboratory performs studies in complementary organismal model systems, including Drosophila and murine models, and human brain tissue.