Positions
- Associate Professor
-
Molecular and Human Genetics
Human Genome Sequencing Center
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Associate Professor
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Michael E. DeBakey Department of Surgery
Baylor College Medicine
Houston, Texas United States
Joint Apointment
Education
- Postdoctoral Fellowship at Manitoba Institute of Cell Biology
- 01/1988 - Winnipeg, Manitoba Canada
- PhD from Laval University
- 08/1985 - Sainte-Foy, Quebec, Quebec Canada
- BSc from Laval University
- 05/1978 - Sainte-Foy, Quebec, Quebec Canada
Websites
Selected Publications
- Nguyen NT, Cotton RT, Harring TR, Guiteau JJ, Gingras MC, Wheeler DA, O'Mahony CA, Gibbs RA, Brunicardi FC, Goss JA "A primer on a hepatocellular carcinoma bioresource bank using the cancer genome atlas guidelines: practical issues and pitfalls.." World J Surg. 2011 Aug;35(8):1732-7. Pubmed PMID: 21221581
- Schwarz LC, Wright JA, Gingras MC, Kondaiah P, Danielpour D, Pimentel M, Sporn MB, Greenberg AH "Aberrant TGF-beta production and regulation in metastatic malignancy.." Growth Factors. 1990;3(2):115-27. Pubmed PMID: 2169772
- Gingras MC, Covington KR, Chang D, Donehower L, Gill AJ, Ittman MM, et al. "Ampullary cancers harbor ELF3 tumor suppressor gene mutations and exhibit frequent WNT dysregulation.." Cell Reports. 2016;14(4):907-19. Pubmed PMID: 26804919
- Becnel LB, Pereira S, Drummond JA, Gingras MC, Covington KR, Kovar CL, Doddapaneni HV, Hu J, Muzny D, McGuire AL, Wheeler DA, Gibbs RA "An open access pilot freely sharing cancer genomic data from participants in Texas.." Scientific Data. 2016 Feb 16;3(160010):doi: 10.1038/sdata.2016.10. Pubmed PMID: 26882539
- Li D, Tanaka M, Brunicardi FC, Fisher WE, Gibbs RA, Gingras MC "Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival.." Cancer. 2011 Jul 1;117(13):2863-72. Pubmed PMID: 21692047
- Voidonikolas G, Kreml SS, Chen C, Fisher WE, Brunicardi FC, Gibbs RA, Gingras MC "Basic principles and technologies for deciphering the genetic map of cancer.." World J Surg. 2009 Apr;33(4):615-29. Pubmed PMID: 19115029
- Harring TR, Guiteau JJ, Nguyen NT, Cotton RT, Gingras MC, Wheeler DA, O'Mahony CA, Gibbs RA, Brunicardi FC, Goss JA "Building a comprehensive genomic program for hepatocellular carcinoma.." World J Surg. 2011 Aug;35(8):1746-50. Pubmed PMID: 21225260
- Gingras MC, Lapillonne H, Margolin JF "CFFM4: a new member of the CD20/FcepsilonRIbeta family.." Immunogenetics. 2001 Aug;53(6):468-76. Pubmed PMID: 11685457
- Gingras MC, Roussel E, Bruner JM, Branch CD, Moser RP "Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue.." J. Neuroimmunol.. 1995 Mar;57(41276):143-53. Pubmed PMID: 7535788
- Voidonikolas G, Gingras MC, Hodges S, McGuire AL, Chen C, Gibbs RA, Brunicardi FC, Fisher WE "Developing a tissue resource to characterize the genome of pancreatic cancer.." World J Surg. 2009 Apr;33(4):723-31. Pubmed PMID: 19137368
- Gingras MC, Margolin JF "Differential expression of multiple unexpected genes during U937 cell and macrophage differentiation detected by suppressive subtractive hybridization.." Exp. Hematol.. 2000 Jan;28(1):65-76. Pubmed PMID: 10658678
- Gingras MC, Szpirer J, Turcotte B, Bélanger L, Szpirer C "Differential regulation of normal and tumor alpha 1-fetoprotein genes in fetal hepatocyte x hepatoma hybrids.." Cancer Res.. 1988 Nov 15;48(22):6371-4. Pubmed PMID: 2460223
- Guertin M, LaRue H, Bernier D, Wrange O, Chevrette M, Gingras MC, Bélanger L "Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.." Mol. Cell. Biol.. 1988 Apr;8(4):1398-407. Pubmed PMID: 2454390
- Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, Bertino JR, Gingras MC, Ittman M, et al "Functional annotation of rare gene aberration drivers of pancreatic cancer.." Nature Communications. 2016 Jan 25;7(10500):doi: 10.1038/ncomms10500. Pubmed PMID: 26806015
- Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, et al. "Genomic analyses identify molecular subtypes of pancreatic cancer.." Nature. 2016;531(7592):47-52. Pubmed PMID: 26909576
- Frank TS, Sun X, Zhang Y, Yang J, Fisher WE, Gingras MC, Li M. "Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer." Cancer Letters. 2015;363(1):1-6. Pubmed PMID: 25890222
- Wang Y, Zhang Y, Yang J, Ni X, Liu S, Li Z, Hodges SE, Fisher WE, Brunicardi FC, Gibbs RA, Gingras MC, Li M "Genomic sequencing of key genes in mouse pancreatic cancer cells.." Curr. Mol. Med.. 2012 Mar 1;12(3):331-41. Pubmed PMID: 22208613
- Bélanger L, Frain M, Baril P, Gingras MC, Bartkowiak J, Sala-Trépat JM. "Glucocorticosteroid suppression of α-fetoprotein synthesis in developing rat liver. Evidence for selective gene repression at the transcriptional level.." Biochemistry. 1981;20:6665-72. Pubmed PMID: 6171301
- Roussel E, Gingras MC, Grimm EA, Roth JA "High expression of adhesion molecules/activation markers with little interleukin-2, interferon gamma, and tumor necrosis factor beta gene activation in fresh tumor-infiltrating lymphocytes from lung adenocarcinoma.." Cancer Immunol. Immunother.. 1995 Jul;41(1):41283. Pubmed PMID: 7641214
- Roussel E, Gingras MC "High-throughput gene expression profiling--a work-in-progress with great potential for proteomics.." Curr Opin Drug Discov Devel. 2006 May;9(3):332-8. Pubmed PMID: 16729729
- Al-Lamki Z, Wali YA, Wasifuddin SM, Zachariah M, Al-Mjeni R, Li C, Muralitharan S, Al-Kharusi K, Gunaratne P, Peterson L, Gibbs R, Gingras MC, Margolin JF "Identification of prognosis markers in pediatric high-risk acute lymphoblastic leukemia.." Pediatr Hematol Oncol. 2005;22(7):629-43. Pubmed PMID: 16166056
- The Cancer Genome Atlas Research Network "Integrated genomic characterization of pancreatic ductal adenocarcinoma." Cancer Cell. 2017;
- Farshidfar F, Zheng S, Gingras MC, Newton Y, Shih J, et al. "Integrative genomic analysis of cholangiocarcinoma identifies distinct IDH-mutant molecular profiles." Cell Reports. 2017;18(11):2780-94. Pubmed PMID: 28297679
- Gingras MC, Roussel E, Roth JA, Moser RP "Little expression of cytokine mRNA by fresh tumour-infiltrating mononuclear leukocytes from glioma and lung adenocarcinoma.." Cytokine. 1995 Aug;7(6):580-8. Pubmed PMID: 8580376
- Roussel E, Gingras MC, Ro JY, Branch C, Roth JA "Loss of alpha 1 beta 1 and reduced expression of other beta 1 integrins and CAM in lung adenocarcinoma compared with pneumocytes.." J Surg Oncol. 1994 Jul;56(3):198-208. Pubmed PMID: 7518021
- Schwarz LC, Gingras MC, Goldberg G, Greenberg AH, Wright JA. "Loss of growth factor dependence and conversion of transforming growth factor-ß1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts." Cancer Research. 1988;48:6999-7003. Pubmed PMID: 3056609
- Patel SG, Zhou G, Liu SH, Li M, Jeong JW, DeMayo FJ, Gingras MC, Gibbs RA, Fisher WE, Brunicardi FC "Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas.." World J Surg. 2009 Apr;33(4):630-7. Pubmed PMID: 19137362
- Campeau PM, Kim JC, Lu JT, Schwartzentruber JA, Abdul-Rahman OA, Schlaubitz S, Murdock DM, Jiang MM, Lammer EJ, Enns GM, Rhead WJ, Rowland J, Robertson SP, Cormier-Daire V, Bainbridge MN, Yang XJ, Gingras MC, Gibbs RA, Rosenblatt DS, Majewski J, Lee BH "Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome.." Am. J. Hum. Genet.. 2012 Feb 10;90(2):282-9. Pubmed PMID: 22265014
- Greenberg AH, Egan SE, Jarolim L, Gingras MC, Wright JA "Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice.." Cancer Res.. 1987 Sep 15;47(18):4801-5. Pubmed PMID: 3621176
- Qiu J, Gunaratne P, Peterson LE, Khurana D, Walsham N, Loulseged H, Karni RJ, Roussel E, Gibbs RA, Margolin JF, Gingras MC "Novel potential ALL low-risk markers revealed by gene expression profiling with new high-throughput SSH-CCS-PCR.." Leukemia. 2003 Sep;17(9):1891-900. Pubmed PMID: 12970791
- Belanger L, Baril P, Guertin M, Gingras MC, Gourdeau H, Anderson A, Hamel D, Boucher JM "Oncodevelopmental and hormonal regulation of alpha 1-fetoprotein gene expression.." Adv. Enzyme Regul.. 1983;21:73-99. Pubmed PMID: 6085825
- Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M, Scarlett CJ, G "Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.." Nature. 2012 Nov 15;491(7424):399-405. Pubmed PMID: 23103869
- Liu S, Ballian N, Belaguli NS, Patel S, Li M, Templeton NS, Gingras MC, Gibbs R, Fisher W, Brunicardi FC "PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer.." Pancreas. 2008 Aug;37(2):210-20. Pubmed PMID: 18665085
- Liu SH, Rao DD, Nemunaitis J, Senzer N, Zhou G, Dawson D, Gingras MC, Wang Z, Gibbs R, Norman M, Templeton NS, Demayo FJ, O'Malley B, Sanchez R, Fisher WE, Brunicardi FC "PDX-1 Is a Therapeutic Target for Pancreatic Cancer, Insulinoma and Islet Neoplasia Using a Novel RNA Interference Platform.." PLoS ONE. 2012;7(8):e40452. Pubmed PMID: 22905092
- Liu SH, Patel S, Gingras MC, Nemunaitis J, Zhou G, Chen C, Li M, Fisher W, Gibbs R, Brunicardi FC "PDX-1: Demonstration of oncogenic properties in pancreatic cancer.." Cancer. 2011 Feb 15;117(4):723-33. Pubmed PMID: 20886630
- Shiao SYPK, Gingras MC "Personalized genomics in the 21st century: implications for nursing research with children and families." Southern Online Journal of Nursing Research. 2010;10(3)
- Gingras MC, Arevalo P, Aguilar-Cordova E "Potential salmon sperm origin of the E3 region insert of the adenovirus 5 dl309 mutant.." Cancer Gene Ther.. 1966;3(3):151-4. Pubmed PMID: 8725878
- Roussel E, Gingras MC, Grimm EA, Bruner JM, Moser RP "Predominance of a type 2 intratumoural immune response in fresh tumour-infiltrating lymphocytes from human gliomas.." Clin. Exp. Immunol.. 1996 Aug;105(2):344-52. Pubmed PMID: 8706344
- Rodriguez JA, Guiteau JJ, Nazareth L, Reid JG, Goss JA, Gibbs RA, Gingras MC "Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms.." World J Surg. 2009 Apr;33(4):647-52. Pubmed PMID: 19082655
- Cotton RT, Li D, Scherer SE, Muzny DM, Hodges SE, Catania RL, Witkiewicz AK, Brody JR, Kennedy EP, Yeo CJ, Brunicardi FC, Gibbs RA, Gingras MC, Fisher WE "Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma.." HPB (Oxford). 2009;11(5):435-44. Pubmed PMID: 19768149
- Zhou G, Gingras MC, Liu SH, Sanchez R, Edwards D, Dawson D, Christensen K, Paganelli G, Gibbs R, Fisher W, Brunicardi FC "SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes.." Surgery. 2011 Dec;150(6):1136-42. Pubmed PMID: 22136833
- Zhou G, Gingras MC, Liu SH, Li D, Li Z, Catania RL, Stehling KM, Li M, Paganelli G, Gibbs RA, Demayo FJ, Fisher WE, Brunicardi FC "The Hypofunctional Effect of P335L Single Nucleotide Polymorphism on SSTR5 Function.." World J Surg. 2011 Aug;35(8):1715-24. Pubmed PMID: 21249361
- Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, et al "Trans-ancestry mutational landscape of hepatocellular carcinoma genomes." Nature Genetics. 2014;46(12):1267-73. Pubmed PMID: 25362482
- Roussel E, Gingras MC "Transendothelial migration induces rapid expression on neutrophils of granule-release VLA6 used for tissue infiltration.." J. Leukoc. Biol.. 1997 Sep;62(3):356-62. Pubmed PMID: 9307074
- Gingras MC, Jarolim L, Finch J, Bowden GT, Wright JA, Greenberg AH "Transient alterations in the expression of protease and extracellular matrix genes during metastatic lung colonization by H-ras-transformed 10T1/2 fibroblasts.." Cancer Res.. 1990 Jul 1;50(13):4061-6. Pubmed PMID: 2191771
- Gingras MC, Lapillonne H, Margolin JF "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development.." Mol. Immunol.. 2002 Mar;38(11):817-24. Pubmed PMID: 11922939
- Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, et al "Whole-genome landscape of pancreatic neuroendocrine tumours." Nature. 2017;543(7643):65-71. Pubmed PMID: 28199314
- Bainbridge MN, Wiszniewski W, Murdock DR, Friedman J, Gonzaga-Jauregui C, Newsham I, Reid JG, Fink JK, Morgan MB, Gingras MC, Muzny DM, Hoang LD, Yousaf S, Lupski JR, Gibbs RA "Whole-genome sequencing for optimized patient management.." Sci Transl Med. 2011 Jun 15;3(87):87re3. Pubmed PMID: 21677200
- Gingras MC, Fisher WE, Gibbs RA, Brunicardi FC. "Direct whole exome sequencing of pancreatic ductal adenocarcinoma." Schwartz's Principles of Surgery, 9th ed.. 2012;
- Gingras MC, Jones RJ. "Exosome targeted therapy, a step in the future." Translational Cancer Research. 2017 Oct 19;6(Suppl 9):S1398-S1401.
- 2. Sabo A, Murdock D, Dugan S, Meng Q, Gingras MC, Hu J, Muzny D, Gibbs R. "Community based recruitment and exome sequencing indicates high diagnostic yield in adults with intellectual disability.." Molecular Genetics and Genomic Medicine. 2020 Aug 7;(doi: 10.1002/mgg3.1439):e1439. Pubmed PMID: 32767738
- Montenegro-Garreaud X, Hansen A, Khayat M, Chander V, Jiang Y, Li H, Mitani T, Jayaseelan J, Shen H, Meng Q, Rosenfeld J, Jhangiani SN, Abarca H, Trubnikova M, Gingras MC, Posey J, Liu P, Lupski JR, Gibbs R. "Phenotypic expansion in KIF1A related dominant disorders: a description of novel variants and review of published cases.." Human Mutation. 2012;
Intellectual Property
- Product Patent (Approved)
Languages
French
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