Positions
- Associate Professor
-
Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine
Houston, TX
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, TX
Education
- PhD from University of British Columbia
- Vancouver, BC Canada
- BSc from Simon Fraser University
- Burnaby, BC Canada
- Postdoctoral Fellowship at Hospital for Sick Children
- Toronto, ON Canada
Professional Statement
The goal of Dr. Marco Gallo's research is to discover the mechanisms by which the epigenome and non-coding genome drive tumorigenesis in pediatric and adult brain tumors. His laboratory consists of an integrated team of bioinformaticians and wet lab scientists who investigate the function of epigenetic and chromatin factors and 3D genome architecture in programming stem-like states in brain tumors.Among other contributions, his research has shed light on the intratumoral organization and evolution of genetic subclones in pediatric high-grade gliomas (Cancer Research, 2019), the link between 3D genome organization and expression of targetable antigens in adult glioblastoma (Genome Research, 2019), how subclonalgenetics influences chromatin organization (Science Advances, 2021) and identified chromatin factors that promote cell state transitions (Nature Communications, 2023).
He has received awards from provincial, national and international organizations, including: the Institute of Cancer Research at the Canadian Institutes of Health Research (CIHR), the Society for Neuro-Oncology and Stand Up To Cancer.
Websites
Selected Publications
- Nikolic A, ... Gallo M "macroH2A2 antagonizes epigenetic programs of stemness in glioblastoma." Nature Communications. 2023;14:3062. Pubmed PMID: 37244935
- Nikolic A, ... Gallo M "Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer." Science Advances. 2021;7:abg6045. Pubmed PMID: 34644115
- Johnston M, ... Gallo M "High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma." Genome Research. 2019;29:1211-1222. Pubmed PMID: 31249064
- Hoffman M, ... Gallo M "Intratumoral genetic and functional heterogeneity in pediatric glioblastoma." Cancer Research. 2019;79:2111-2123. Pubmed PMID: 30877103
- Gallo M, ... Dirks PB "MLL5 orchestrates a cancer self-renewal state by repressing the histone variant H3.3 and globally reorganizing chromatin." Cancer Cell. 2015;28:715-729. Pubmed PMID: 26626085
- Johnston MJ, ... Gallo M "TULIPs decorate the three-dimensional genome of PFA ependymoma." Cell. 2024;187:4926-4945. Pubmed PMID: 38986619
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