Positions

Sr. Staff Scientist

Pathology
Center for Drug Discovery
Baylor College of Medicine
Houston, TX US

Addresses

Center for Drug Discovery (Lab)

BCMS-S213
Houston, TX 77030
United States
Phone: (713) 798-6283
kurt.bohren@bcm.edu

Education

MEd from University of Houston

Houston, Texas United States

PhD from University of Bern

Bern, Switzerland

Professional Statement

DNA-encoded chemical libraries (DECLs) are promising tools in drug discovery. DECL technology allows the synthesis and screening of chemical libraries of unprecedented size at moderate costs. I am fortunate to have joined a team that can generate up to 100 million different DNA-tagged molecules in a single tube. Such a mixture can be used to target specific recombinant proteins of interest. Any molecular entities that bind with a target protein can be identified thanks to their DNA barcodes. Down-stream analyses using our modern biophysical tools such as SPR, ITC, NMR, and many others help validate a “hit”, and may lead to new drug candidates, or answer basic biological questions.

Selected Publications

• "The entire list in PubMed." ;

Memberships

• American Chemical Society

member (01/1996)

• American Association for the Advancement of Science

member (04/1988)

Languages

German, French