In Young Park

In Young Park, Ph.D.

Picture

In Young Park, Ph.D.

Assistant Professor

Email

ipark@bcm.edu

Positions

Assistant Professor: Department of Molecular and Cellular Biology
Center for Precision Environmental Health (CPEH)

Education

PhD from Korea Advanced Institute of Science and Technology (KAIST): 08/2004 - Daejeon, South Korea; Biological Sciences

MS from Korea Advanced Institute of Science and Technology (KAIST): 02/1996 - Daejeon, South Korea; Life Sciences

BS from Korea Advanced Institute of Science and Technology (KAIST): 02/1990 - Daejeon, South Korea; Biology

Professional Interests

Post-translational Regulation of Cytoskeleton
Methylation of Cytoskeletal Proteins
Regulation of Microtubules

Selected Publications

Park I. Y., Chowdhury P., Tripathi D. N., Powell R. T., Dere R., Terzo E. A., Rathmell W. K., & Walker C. L. "Methylated α-tubulin antibodies recognize a new microtubule modification on mitotic microtubules." MAbs. 2016;
Park, I. Y.*, Powell, R. T.*, Tripathi, D. N., Dere, R., Ho, T. H., Blasius T. L., Chiang, Y.-C., Davis, I. J., Fahey C. C., Hacker, K. E., Verhey, K. J., Bedford, M. T., Jonasch E., Rathmell, W. K., & Walker, C. L. "Dual chromatin and cytoskeletal remodeling by SETD2." Cell. 2016;166(4):950-62.
Ho, T. H.*, Park, I. Y.* et. al. "High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma." Oncogene. 2016;35(12):1565-74.
"For full publication list: https://www.ncbi.nlm.nih.gov/myncbi/in%20young.park.2/bibliography/public/." ;

Koenning M, Wang X, Karki M, Jangid RK, Kearns S, Tripathi DN, Cianfrocco M, Verhey KJ, Jung SY, Coarfa C, Ward CS, Kalish BT, Grimm SL, Rathmell WK, Mostany R, Dere R, Rasband MN, Walker CL*, Park IY*. *Co-corresponding author. "Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice.." Brain.. 2021; Pubmed PMID: 34014281
Seervai RNH, Jangid RK, Karki M, Tripathi DN, Jung SY, Kearns SE, Verhey KJ, Cianfrocco MA, Millis BA, Tyska MJ, Mason FM, Rathmell WK, Park IY*, Dere R*, and Walker CL*. *Co-corresponding author. "The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase.." Sci Adv.. 2020 Oct 2;6(40) Pubmed PMID: 33008892
Karki M, Jangid RK, Anish R, Seervai RNH, Bertocchio JP, Hotta T, Msaouel P, Jung SY, Grimm SL, Coarfa C, Weissman BE, Ohi R, Verhey KJ, Hodges HC, Burggren W, Dere R, Park IY, Prasad BVV, Rathmell WK, Walker CL, Tripathi DN. "A cytoskeletal function for PBRM1 reading methylated microtubules.." Sci Adv.. 2021 Apr 2;7(14) Pubmed PMID: 33811077
Chiang YC*, Park IY*, Terzo EA, Tripathi DN, Mason FM, Fahey CC, Karki M, Shuster CB, Sohn BH, Chowdhury P, Powell RT, Ohi R, Tsai YS, de Cubas AA, Khan A, Davis IJ, Strahl BD, Parker JS, Dere R, Walker CL, Rathmell WK. *Co-first author. "SETD2 Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma.." Cancer Res.. 2018 Jun 15;78(12):3135-3146. Pubmed PMID: 29724720
Sohn BH, Park IY, Shin JH, Yim SY, Lee JS. "Glutamine synthetase mediates sorafenib sensitivity in β-catenin-active hepatocellular carcinoma cells.." Exp Mol Med.. 2018 Jan 5;50(1) Pubmed PMID: 29303508
Sun M, Tong P, Kong W, Dong B, Huang Y, Park IY, Zhou L, Liu XD, Ding Z, Zhang X, Bai S, German P, Powell R, Wang Q, Tong X, Tannir NM, Matin SF, Rathmell WK, Fuller GN, McCutcheon IE, Walker CL, Wang J, Jonasch E. "HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas.." Cancer Res.. 2017 Oct 1;77(19):5313-5326. Pubmed PMID: 28807937
Sowers JL, Mirfattah B, Xu P, Tang H, Park IY, Walker C, Wu P, Laezza F, Sowers LC, Zhang K. "Quantification of histone modifications by parallel-reaction monitoring: a method validation.." Anal Chem.. 2015 Oct 6;87(19):10006-14. Pubmed PMID: 26356480