Farook Jahoor, Ph.D.
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Positions
- Distinguished Professor Emeritus
-
Pediatrics-Nutrition
Baylor College of Medicine
Houston, TX US
Education
- PhD from University Of The West Indies
- 01/1982 - Kingston, St Andrew Jamaica
- Human Nutrition/Metabolism
- MSc from University Of The West Indies
- 01/1976 - Kingston, St Andrew Jamaica
- Human Nutrition
- BSc from McMaster University
- 01/1973 - Hamilton, Ontario Canada
- Biological Sciences
Professional Interests
- Intermediary metabolism in different pathological states
Websites
Selected Publications
- Jahoor F, Hsu JW, Mehta PB, Keene KR, Gaba R, Mulukutla SN, Caducoy E, Peacock WF, Patel SG, Rasmus B, Ake L, Balasubramanyam A. "Metabolomic profiling of patients with A-β+ Ketosis-Prone Diabetes during diabetic ketoacidosis.." Diabetes. 2021 May 21; Pubmed PMID: 34021044
- Shivakumar N, Sivadas A, Devi S, Jahoor F, McLaughlin J, Smith CP, Kurpad AV, Mukhopadhyay A. "Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.." PLoS One. 2021 May 14;16(5) Pubmed PMID: 33989353
- Premranjan Kumar 1 , Chun Liu 1 , Jean W Hsu 2 , Shaji Chacko 2 , Charles Minard 3 , Farook Jahoor 2 , Rajagopal V Sekhar 1 "Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Re." Clin Transl Med .. 2021 Mar 27;11(3) Pubmed PMID: 33783984
- Hong Chang Tan 1 , Jean W Hsu 2 , Jean-Paul Kovalik 3 , Alvin Eng 4 , Weng Hoong Chan 4 , Chin Meng Khoo 5 , E Shyong Tai 5 , Shaji Chacko 2 , Farook Jahoor 2 "Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy." J Nutr .. 2020 Dec 10;150(12):3180-3189. Pubmed PMID: 33097955
- Premranjan Kumar 1 , Chun Liu 1 , James W Suliburk 2 , Charles G Minard 3 , Raja Muthupillai 4 , Shaji Chacko 5 , Jean W Hsu 5 , Farook Jahoor 5 , Rajagopal V Sekhar 1 6 Affiliations "Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clin." Biomedicines. 2020 Sep 30;8(10):1-22. Pubmed PMID: 33007928
- Shivakumar N, Kashyap S, Kishore S, Thomas T, Varkey A, Devi S, Preston T, Jahoor F, Sheshshayee MS, Kurpad AV. "Protein-quality evaluation of complementary foods in Indian children.." Am J Clin Nutr.. 2019 May 1;109(5):1319-1327. Pubmed PMID: 30920607
- Schutt AK, Blesson CS, Hsu JW, Valdes CT, Gibbons WE, Jahoor F, Yallampalli C. "Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid.." Reprod Biol Endocrinol.. 2019 Jan 17;17(1) Pubmed PMID: 30654812
- Tan HC, Hsu JW, Khoo CM, Tai ES, Yu S, Chacko S, Lai OF, Jahoor F. "Alterations in branched-chain amino acid kinetics in nonobese but insulin-resistant Asian men." Am J Clin Nutr.. 2018 Dec 1;108(6):1220-1228. Pubmed PMID: 30358799
- Lutchmansingh FK, Hsu JW, Bennett FI, Badaloo AV, McFarlane-Anderson N, Gordon-Strachan GM, Wright-Pascoe RA, Jahoor F, Boyne MS. "Glutathione metabolism in type 2 diabetes and its relationship with microvascular complications and glycemia.." PLoS One. 2018 Jun 7;13(6) Pubmed PMID: 29879181
- May T, Klatt KC, Smith J, Castro E, Manary M, Caudill MA, Jahoor F, Fiorotto ML. "Choline Supplementation Prevents a Hallmark Disturbance of Kwashiorkor in Weanling Mice Fed a Maize Vegetable Diet: Hepatic Steatosis of Undernutrition.." Nutrients. 2018 May 22;10(5) Pubmed PMID: 29786674
- Mulukutla SN, Hsu JW, Gaba R, Bohren KM, Guthikonda A, Iyer D, Ajami NJ, Petrosino JF, Hampe CS, Ram N, Jahoor F, Balasubramanyam A. "Arginine Metabolism Is Altered in Adults with A-β + Ketosis-Prone Diabetes.." J Nutr .. 2018 Feb 1;148(2):185-193. Pubmed PMID: 29490093
- El-Hattab AW, Jahoor F. "The utility of arginine-citrulline stable isotope tracer infusion technique in the assessment of nitric oxide production in MELAS syndrome." Int J Cardiol. 2018 Mar 1;254:282. Pubmed PMID: 28041706
- El-Hattab AW, Jahoor F. "Assessment of Nitric Oxide Production in Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome with the Use of a Stable Isotope Tracer Infusion Technique." J Nutr .. 2017 Jul;147(7):1251-1257. Pubmed PMID: 28515163
Projects
- Effect of dietary milk and dairy (M&D) food intake on body weight and cardio- metabolic health in young children
- USDA/ARS (07/2019 - 06/2024)
- Houston
- The goal of this project is to determine the effect of habitual M&D foods consumption on energy balance and whether they also have a protective effect against early cardiovascular and metabolic diseases
- Obesity-Related Glycine Deficiency: Investigating a Long-standing Metabolic Paradox Using Bedside and Bench Approaches.
- National Medical Research Council of Singapore (08/2018 - 03/2022)
- Singapore
- The goal of this project is to test the hypothesize that low glycine concentration in morbid obesity is due to an increase in glycine utilization to support GSH synthesis and that GSH concentration is significantly low in morbid obesity because of elevated oxidative stress.
- Role of FGF21 in the pathogenesis of HIV-associated metabolic disease
- NIH (12/2020 - 12/2025)
- Houston
- The goal of this project is to establish mechanistic connections between increased FGF21 levels, WAT browning and the observed metabolic abnormalities in Vpr mice and in persons living with HIV infection.
- Arginine and nitric oxide synthesis in the pathogenesis of ketosis-prone diabetes
- NIH (04/2014 - 12/2021)
- Houston
- The goal of this project is to determine whether abnormal metabolism of arginine, citrulline, glutamine and nitric oxide underlie insulin secretory defects in KPD
Funding
- Obesity-Related Glycine Deficiency: Investigating a Long-standing Metabolic Paradox Using Bedside and Bench Approaches - #300019262/SGH REF: SA2020-006 (08/01/2018 - 03/31/2022) Grant funding from National Med Res Council of Singapore
- The goal of this project is to test the hypothesize that low glycine concentration in morbid obesity is due to an increase in glycine utilization to support GSH synthesis and that GSH concentration is significantly low in morbid obesity because of elevated oxidative stress.
- Role of FGF21 in the pathogenesis of HIV-associated metabolic disease - #1R01DK126042-01 (12/01/2020 - 11/30/2024) Grant funding from NIH NIDDK
- The goal of this project is to establish mechanistic connections between increased FGF21 levels, WAT browning and the observed metabolic abnormalities in Vpr mice and in persons living with HIV infection.
- Arginine and nitric oxide synthesis in the pathogenesis of ketosis-prone diabetes - #1 R01 DK101411 (04/01/2014 - 12/31/2021) Grant funding from NIH NIDDK
- The goal of this project is to determine whether abnormal metabolism of arginine, citrulline, glutamine and nitric oxide underlie insulin secretory defects in KPD
- Effect of dietary milk and dairy (M&D) food intake on body weight and cardio-metabolic health in young children. - #USDA CRIS FY'20 3092-5-001-057 (07/01/2019 - 06/30/2024) Grant funding from USDA/ARS
- The goal of this project is to determine the effect of habitual M&D foods consumption on energy balance and whether they also have a protective effect against early cardiovascular and metabolic diseases.
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