Elizabeth A. Olmsted-Davis, Ph.D.
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Elizabeth A. Olmsted-Davis, Ph.D.
Associate Professor
Positions
- Associate Professor
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Pediatrics-Hem-Onc Cell & Gene
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Baylor College of Medicine (Office)
-
N-1010
Houston, TX 77030
United States
Phone: (713) 798-1253
edavis@bcm.edu
Education
- Advanced Training from University Of Pennsylvania
- 01/1998 - Philadelphia, PA United States
- Ph.D. from University Of Rochester
- 01/1991 - Rochester, NY United States
- M.S. from University Of Rochester
- 01/1988 - Rochester, NY United States
- B.S. from Allegheny College
- 01/1986 - Meadeville, PA United States
- Advanced Training from Wyeth-Ayerst Research
- 01/1994 - Philadelphia, PA United States
Professional Interests
- Tissue engineering
- Gene therapy
- BMP2
- Spinal fusion
- Hospital Medicine
Websites
Selected Publications
- Gugala Z, Davis AR, Fouletier-Dilling CM, Gannon FH, Lindsey RW, Olmsted-Davis EA "Adenovirus BMP2-induced osteogenesis in combination with collagen carriers.." Biomaterials. 2007 Oct;28(30):4469-79. Pubmed PMID: 17645942
- Olmsted EA, Blum JS, Rill D, Yotnda P, Gugala Z, Lindsey RW, Davis AR "Adenovirus-mediated BMP2 expression in human bone marrow stromal cells.." J. Cell. Biochem..;82(1):41599. Pubmed PMID: 11400159
- Dewan AK, Dewan RA, Calderon N, Fuentes A, Lazard Z, Davis AR, Heggeness M, Hipp JA, Olmsted-Davis EA "Assessing mechanical integrity of spinal fusion by in situ endochondral osteoinduction in the murine model.." J Orthop Surg Res. 2010;5:58. Pubmed PMID: 20727195
- Gannon FH, Kaplan FS, Olmsted E, Finkel GC, Zasloff MA, Shore E "Bone morphogenetic protein 2/4 in early fibromatous lesions of fibrodysplasia ossificans progressiva.." Hum. Pathol.. 1997 Mar;28(3):339-43. Pubmed PMID: 9042799
- Olmsted EA, Kaplan FS, Shore EM "Bone morphogenetic protein-4 regulation in fibrodysplasia ossificans progressiva.." Clin. Orthop. Relat. Res.. 2003 Mar;(408):331-43. Pubmed PMID: 12616078
- Hsu CW, Olabisi RM, Olmsted-Davis EA, Davis AR, West JL "Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption.." J Biomed Mater Res A. 2011 Jul;98(1):53-62. Pubmed PMID: 21523904
- Lazard ZW, Heggeness MH, Hipp JA, Sonnet C, Fuentes AS, Nistal RP, Davis AR, Olabisi RM, West JL, Olmsted-Davis EA "Cell-based gene therapy for repair of critical size defects in the rat fibula.." J. Cell. Biochem.. 2011 Jun;112(6):1563-71. Pubmed PMID: 21344484
- Lanchoney TF, Olmsted EA, Shore EM, Gannon FA, Rosen V, Zasloff MA, Kaplan FS "Characterization of bone morphogenetic protein 4 receptor in fibrodysplasia ossificans progressiva.." Clin. Orthop. Relat. Res.. 1998 Jan;(346):38-45. Pubmed PMID: 9577408
- Azhdarinia A, Wilganowski N, Robinson H, Ghosh P, Kwon S, Lazard ZW, Davis AR, Olmsted-Davis E, Sevick-Muraca EM "Characterization of chemical, radiochemical and optical properties of a dual-labeled MMP-9 targeting peptide.." Bioorg. Med. Chem.. 2011 Jun 15;19(12):3769-76. Pubmed PMID: 21612930
- Stephens EH, Saltarrelli JG, Baggett LS, Nandi I, Kuo JJ, Davis AR, Olmsted-Davis EA, Reardon MJ, Morrisett JD, Grande-Allen KJ "Differential proteoglycan and hyaluronan distribution in calcified aortic valves.." Cardiovasc. Pathol..;20(6):334-42. Pubmed PMID: 21185747
- Liu SH, Davis A, Li Z, Ballian N, Davis E, Wang XP, Fisher W, Brunicardi FC "Effective ablation of pancreatic cancer cells in SCID mice using systemic adenoviral RIP-TK/GCV gene therapy.." J. Surg. Res.. 2007 Jul;141(1):45-52. Pubmed PMID: 17512546
- Bosch P, Fouletier-Dilling C, Olmsted-Davis EA, Davis AR, Stice SL "Efficient adenoviral-mediated gene delivery into porcine mesenchymal stem cells.." Mol. Reprod. Dev.. 2006 Nov;73(11):1393-403. Pubmed PMID: 16897738
- Fouletier-Dilling CM, Gannon FH, Olmsted-Davis EA, Lazard Z, Heggeness MH, Shafer JA, Hipp JA, Davis AR "Efficient and rapid osteoinduction in an immune-competent host.." Hum. Gene Ther.. 2007 Aug;18(8):733-45. Pubmed PMID: 17691858
- Olmsted EA, Gannon FH, Wang ZQ, Grigoriadis AE, Wagner EF, Zasloff MA, Shore EM, Kaplan FS "Embryonic overexpression of the c-Fos protooncogene. A murine stem cell chimera applicable to the study of fibrodysplasia ossificans progressiva in humans.." Clin. Orthop. Relat. Res.. 1998 Jan;(346):81-94. Pubmed PMID: 9577414
- Bikram M, Fouletier-Dilling C, Hipp JA, Gannon F, Davis AR, Olmsted-Davis EA, West JL "Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells.." Ann Biomed Eng. 2007 May;35(5):796-807. Pubmed PMID: 17340196
- Yeh GL, Mathur S, Wivel A, Li M, Gannon FH, Ulied A, Audi L, Olmstead EA, Kaplan FS, Shore EM "GNAS1 mutation and Cbfa1 misexpression in a child with severe congenital platelike osteoma cutis.." J. Bone Miner. Res.. 2000 Nov;15(11):2063-73. Pubmed PMID: 11092389
- Salisbury E, Sonnet C, Heggeness M, Davis AR, Olmsted-Davis E "Heterotopic ossification has some nerve.." Crit. Rev. Eukaryot. Gene Expr.. 2010;20(4):313-24. Pubmed PMID: 21395504
- Olabisi RM, Lazard ZW, Franco CL, Hall MA, Kwon SK, Sevick-Muraca EM, Hipp JA, Davis AR, Olmsted-Davis EA, West JL "Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification.." Tissue Eng Part A. 2010 Dec;16(12):3727-36. Pubmed PMID: 20673027
- Olmsted-Davis E, Gannon FH, Ozen M, Ittmann MM, Gugala Z, Hipp JA, Moran KM, Fouletier-Dilling CM, Schumara-Martin S, Lindsey RW, Heggeness MH, Brenner MK, Davis AR "Hypoxic adipocytes pattern early heterotopic bone formation.." Am. J. Pathol.. 2007 Feb;170(2):620-32. Pubmed PMID: 17255330
- Mauro LJ, Olmsted EA, Skrobacz BM, Mourey RJ, Davis AR, Dixon JE "Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation.." J. Biol. Chem.. 1994 Dec 2;269(48):30659-67. Pubmed PMID: 7527035
- Dacquin R, Mee PJ, Kawaguchi J, Olmsted-Davis EA, Gallagher JA, Nichols J, Lee K, Karsenty G, Smith A "Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar.." Dev. Dyn.. 2004 Apr;229(4):826-34. Pubmed PMID: 15042706
- Xue W, Wallin R, Olmsted-Davis EA, Borrás T "Matrix GLA protein function in human trabecular meshwork cells: inhibition of BMP2-induced calcification process.." Invest. Ophthalmol. Vis. Sci.. 2006 Mar;47(3):997-1007. Pubmed PMID: 16505034
- Rodenberg E, Azhdarinia A, Lazard ZW, Hall M, Kwon SK, Wilganowski N, Salisbury EA, Merched-Sauvage M, Olmsted-Davis EA, Sevick-Muraca EM, Davis AR "Matrix metalloproteinase-9 is a diagnostic marker of heterotopic ossification in a murine model.." Tissue Eng Part A. 2011 Oct;17(19):2487-96. Pubmed PMID: 21599541
- Liu SH, Smyth-Templeton N, Davis AR, Davis EA, Ballian N, Li M, Liu H, Fisher W, Brunicardi FC "Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice.." Surgery. 2011 Apr;149(4):484-95. Pubmed PMID: 21295812
- Fouletier-Dilling CM, Bosch P, Davis AR, Shafer JA, Stice SL, Gugala Z, Gannon FH, Olmsted-Davis EA "Novel compound enables high-level adenovirus transduction in the absence of an adenovirus-specific receptor.." Hum. Gene Ther.. 2005 Nov;16(11):1287-97. Pubmed PMID: 16259562
- Gugala Z, Olmsted-Davis EA, Gannon FH, Lindsey RW, Davis AR "Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type.." Gene Ther.. 2003 Aug;10(16):1289-96. Pubmed PMID: 12883525
- Maduro MR, Davis E, Davis A, Lamb DJ "Osteotesticular protein tyrosine phosphatase expression in rodent testis.." J. Urol.. 2002 May;167(5):2282-3. Pubmed PMID: 11956493
- Shafer J, Davis AR, Gannon FH, Fouletier-Dilling CM, Lazard Z, Moran K, Gugala Z, Ozen M, Ittmann M, Heggeness MH, Olmsted-Davis E "Oxygen tension directs chondrogenic differentiation of myelo-monocytic progenitors during endochondral bone formation.." Tissue Eng.. 2007 Aug;13(8):2011-9. Pubmed PMID: 17518751
- Mauro LJ, Olmsted EA, Davis AR, Dixon JE "Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells.." Endocrinology. 1996 Mar;137(3):925-33. Pubmed PMID: 8603605
- Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR "Primitive adult hematopoietic stem cells can function as osteoblast precursors.." Proc. Natl. Acad. Sci. U.S.A.. 2003 Dec 23;100(26):15877-82. Pubmed PMID: 14673088
- Olmsted EA, O'Brien L, Henshaw EC, Panniers R "Purification and characterization of eukaryotic initiation factor (eIF)-2 alpha kinases from Ehrlich ascites tumor cells.." J. Biol. Chem.. 1993 Jun 15;268(17):12552-9. Pubmed PMID: 8099583
- Salisbury E, Rodenberg E, Sonnet C, Hipp J, Gannon FH, Vadakkan TJ, Dickinson ME, Olmsted-Davis EA, Davis AR "Sensory nerve induced inflammation contributes to heterotopic ossification.." J. Cell. Biochem.. 2011 Oct;112(10):2748-58. Pubmed PMID: 21678472
- Wang X, Olmsted-Davis E, Davis A, Liu S, Li Z, Yang J, Brunicardi FC "Specific targeting of pancreatic islet cells in vivo by insulin-promoter-driven adenoviral conjugated reporter genes.." World J Surg. 2006 Aug;30(8):1543-52. Pubmed PMID: 16855800
- DeStefano J, Olmsted E, Panniers R, Lucas-Lenard J "The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells.." J. Virol.. 1990 Sep;64(9):4445-53. Pubmed PMID: 2166823
- Olmsted-Davis EA, Gugala Z, Gannon FH, Yotnda P, McAlhany RE, Lindsey RW, Davis AR "Use of a chimeric adenovirus vector enhances BMP2 production and bone formation.." Hum. Gene Ther.. 2002 Jul 20;13(11):1337-47. Pubmed PMID: 12162816
- Dilling CF, Wada AM, Lazard ZW, Salisbury EA, Gannon FH, Vadakkan TJ, Gao L, Hirschi K, Dickinson ME, Davis AR, Olmsted-Davis EA "Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification.." J. Bone Miner. Res.. 2010 May;25(5):1147-56. Pubmed PMID: 19839764
- Elizabeth A. Olmsted, Frederick S. Kaplan, and Eileen M. Shore "Mechanisms Controlling Bone Morphogenetic Protein 4 Message Expression in Fibrodysplasia Ossificans Progressiva." Clinic Ortho Rel Res. 2003;408:331-343.
- Xiaoping Wang, Elizabeth Olmsted-Davis, Shihe Liu, Zhijun Li, Jie Yang, Alan Davis, Ph.D., F. Charles Brunicardi "In vivo specific targeting of pancreatic islet cells by adeno-RIP-LacZ gene. World J Surg." World J Surg. 2006;(8):1543-1552.
- Ronke M Olabisi, Zawaunyka Lazard, Michael Heggeness, Kevin M Moran, John A Hipp, Ashvin Dewan, Alan R. Davis, Jennifer L. West; Elizabeth A. Olmsted-Davis "An Injectable Method for Spine Fusion." Spine J. 2011 Jun;11(6):545-556. Pubmed PMID: 21292563
- Jennifer L. Mumaw, Erin Jordan, Corinne Sonnet, Ronke Olabisi, Elizabeth A. Olmsted-Davis, Alan R. Davis, J. Peroni, J. L. West, Franklin West, Yangqing Lu and Steven L. Stice "Heterotrophic Ossification with Cryopreserved Poly (ethylene glycol) Microencapsulated BMP2 Expressing MSCs." Int J Biomater. 2012 Feb 7;2012:861794. Pubmed PMID: 22500171
- Salisbury E, Hipp J, Olmsted-Davis EA, Davis AR, Heggeness MH, Gannon FH "Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels." Hum Pathol. 2012 Dec;43(12):2213-2222. Pubmed PMID: 22748303
- Elizabeth Stephens; Jerome Saltarrelli; Liezl R Balaoing, BS; Scott Baggett; Indrajit Nandi; Kristin Anderson; Joel Morrisett; Michael Reardon; Melanie Simpson; Paul Weigel; Elizabeth Olmsted-Davis; Alan Davis; Kathryn Jane Grande-Allen "Hyaluronan turnover and hypoxic brown adipocytic differentiation are co-localized with ossification in calcified human aortic valves." Pathology Research and Practice. 2012 Nov 15;208(11):642-650. Pubmed PMID: 23017666
- Elizabeth A. Salisbury, ZaWaunyka W. Lazard, Eroboghene Ubogu, Alan R. Davis, Elizabeth A. Olmsted-Davis. "Transient Brown Adipocyte-Like Cells Derived from Peripheral Nerve Progenitors in Response to BMP2." Stem Cells Translational Medicine. 2012 Dec 1;12:874-885. Pubmed PMID: 23283549
- Lee M. Reichel, M.D.; Elizabeth Salisbury, PH.D.; Michael J Moustoukas, M.D.; Alan R Davis, PH.D.; Elizabeth Olmsted-Davis, Ph.D. "Molecular Mechanisms of Heterotopic Ossification." J Hand Surg Am. 2014 Mar;39(3):563-566.
- Corinne Sonnet, Ronke Olabisi, Chartrisa Simpson, Michael Weh, John Peroni, Zbigniew Gugala, John A. Hipp, Francis H. Gannon, Ronald W. Lindsey, Steven Stice, Michael H. Heggeness, Alan R. Davis, Jennifer L. West; Elizabeth A. Olmsted-Davis "Injection of Osteoinductive Microspheres Leads to Rapid Healing of Critical Size Femoral Defects in Wild Type Rats." J Orthop Res. 2013 Oct;31(10):1597-604. Pubmed PMID: 23832813
- Lu Y, Darne CD, Tan IC, Zhu B, Hall MA, Lazard ZW, Davis AR, Simpson L, Sevick-Muraca EM, Olmsted-Davis EA "Far-red fluorescence gene reporter tomography for determination of placement and viability of cell-based gene therapies.." Opt Express. 2013 Oct 7;21(20):24129-38. Pubmed PMID: 24104323
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