Debananda Pati, M.S., Ph.D.
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Debananda Pati, M.S., Ph.D.
Professor
Positions
- Professor
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Pediatrics-Oncology
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Education
- Postdoctoral Fellowship at Baylor College Of Medicine
- 01/2001 - Houston, Texas United States
- PhD from University Of Calgary
- 01/1995 - Calgary, Canada
- MSc from University Of Buckingham
- 01/1988 - Buckingham, United Kingdom
Professional Interests
- Role of Chromosomal Cohesion and Separation in Aneuploidy and Tumorigenesis
Websites
Selected Publications
- Zhang N, Kuznetsov SG, Sharan SK, Li K, Rao PH, Pati D "A handcuff model for the cohesin complex.." J. Cell Biol.. 2008 Dec 15;183(6):1019-31. Pubmed PMID: 19075111
- Meyer R, Fofanov V, Panigrahi A, Merchant F, Zhang N, Pati D "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.." Clin. Cancer Res.. 2009 Apr 15;15(8):2703-10. Pubmed PMID: 19351757
- Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC and Pati D. "Identification and characterization of Separase Inhibitors (Sepins) for Cancer Therapy." J. Biomolecular Screening. 2014;19(6):878-889. Pubmed PMID: 24525869
- Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D "Overexpression of Separase induces aneuploidy and mammary tumorigenesis.." Proc. Natl. Acad. Sci. U.S.A.. 2008 Sep 2;105(35):13033-8. Pubmed PMID: 18728194
- Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. "Overexpression of Separase induces aneuploidy and mammary tumorigenesis." PNAS. 2008 Sep 2;105(35):13033-8.
- Mukherjee, M, Ge, G., Zhang N, Edwards D, Sumazin, P., Sharan, S, Rao PH, Medina D, Pati D "MMTV-Espl1 Transgenic Mice Develop Aneuploid, Estrogen Receptor Alpha (ERα)-Positive Mammary Adenocarcinomas." Oncogene. 2014;48(33):5511-22. Pubmed PMID: 4032816
- Panigrahi AK, Pati D "Higher-order orchestration of hematopoiesis: Is cohesin a new player?." Exp. Hematol.. 2012 Dec;40(12):967-73. Pubmed PMID: 23022223
- Panigrahi AK, Zhang N, Otta SK, Pati D "A cohesin-RAD21 interactome.." Biochem. J.. 2012 Mar 15;442(3):661-70. Pubmed PMID: 22145905
- Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, Adamson PC, Ingle AM, Wright J, Brockman AH, Paton M, Blaney SM "A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study.." Clin. Cancer Res.. 2007 Mar 1;13(5):1516-22. Pubmed PMID: 17332297
- Panigrahi AK, Zhang N, Mao Q, Pati D "Calpain-1 cleaves rad21 to promote sister chromatid separation.." Mol. Cell. Biol.. 2011 Nov;31(21):4335-47. Pubmed PMID: 21876002
- Lu XY, Lu Y, Zhao YJ, Jaeweon K, Kang J, Xiao-Nan L, Ge G, Meyer R, Perlaky L, Hicks J, Chintagumpala M, Cai WW, Ladanyi M, Gorlick R, Lau CC, Pati D, Sheldon M, Rao PH "Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma.." Mol. Cancer Res.. 2008 Jun;6(6):937-46. Pubmed PMID: 18567798
- Basu D, Zhang N, Panigrahi AK, Horton TM, Pati D "Development and validation of a fluorogenic assay to measure separase enzyme activity.." Anal. Biochem.. 2009 Sep 15;392(2):133-8. Pubmed PMID: 19497291
- Eliseeva E, Pati D, Diccinanni MB, Yu AL, Mohsin SK, Margolin JF, Plon SE "Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.." Cell Growth Differ.. 2001 Aug;12(8):427-33. Pubmed PMID: 11504708
- Zhang N, Pati D "Handcuff for sisters: a new model for sister chromatid cohesion.." Cell Cycle. 2009 Feb 1;8(3):399-402. Pubmed PMID: 19177018
- Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D "Hormone-induced chromosomal instability in p53-null mammary epithelium.." Cancer Res.. 2004 Aug 15;64(16):5608-16. Pubmed PMID: 15313898
- Pati D, Meistrich ML, Plon SE "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.." Mol. Cell. Biol.. 1999 Jul;19(7):5001-13. Pubmed PMID: 10373550
- Zhang N, Panigrahi AK, Mao Q, Pati D "Interaction of Sororin Protein with Polo-like Kinase 1 Mediates Resolution of Chromosomal Arm Cohesion.." J. Biol. Chem.. 2011 Dec 2;286(48):41826-37. Pubmed PMID: 21987589
- Pati D, Habibi HR "Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary.." Biol. Reprod.. 2002 Mar;66(3):813-22. Pubmed PMID: 11870090
- Pati D, Zhang N, Plon SE "Linking sister chromatid cohesion and apoptosis: role of Rad21.." Mol. Cell. Biol.. 2002 Dec;22(23):8267-77. Pubmed PMID: 12417729
- Pati D "Oncogenic activity of separase.." Cell Cycle. 2008 Nov 15;7(22):3481-2. Pubmed PMID: 19001849
- Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, Bertuch AA, Blaney SM, Delaney SL, Hegde M, Berg SL "Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.." Mol. Cancer Ther.. 2009 Aug;8(8):2232-42. Pubmed PMID: 19671751
- Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK "RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.." J. Cell Biol.. 2007 Feb 26;176(5):581-92. Pubmed PMID: 17312021
- Pati D, Keller C, Groudine M, Plon SE "Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA.." Mol. Cell. Biol.. 1997 Jun;17(6):3037-46. Pubmed PMID: 9154802
- Panigrahi AK, Pati D "Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer.." Crit. Rev. Oncol. Hematol.. 2009 Dec;72(3):181-93. Pubmed PMID: 19162508
- Mukherjee M, Ge G, Zhang N, Huang E, Nakamura LV, Minor M, Fofanov V, Rao PH, Herron A, Pati D "Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.." PLoS ONE. 2011;6(7):e22167. Pubmed PMID: 21799785
- Zhang N, Pati D "Sororin is a master regulator of sister chromatid cohesion and separation.." Cell Cycle. 2012 Jun 1;11(11):2073-83. Pubmed PMID: 22580470
Intellectual Property
- Product Patent #PCT/US2014/061353 (Pending)
- In some embodiments, the present disclosure pertains to compositions with compounds that inhibit Separase activity. In additional embodiments, the present disclosure pertains to methods of treating a tumor in a subject by administering one or more compositions of the present disclosure to the subject.
- Co Inventors: Nenggang Zhang
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