Positions
- Professor Emeritus
-
Medicine-Cardiovascular Sciences
Baylor College of Medicine
Houston, TX US
- Adjunct Professor
-
Bioengineering
Rice University
Houston, TX
- Adjunct (Associate) Professor
-
Electrical and Mechanical Engineering
University of Houston
Houston, TX
Education
- B.S. from University Of Washington
- 06/1966 - Seattle, WA United States
- Electrical Engineering
- Ph.D. from University Of Washington
- 12/1970 - Seattle, WA United States
- Post-doctoral Fellowship from Rice University
- 01/1973 - Houston, Texas United States
Honors & Awards
- NDEA Title IV Fellow
- 01/1966 - 01/1969
- NIH Research Career Development Award
- 01/1976 - 01/1981
- NIH MERIT Award
- 01/1991 - 01/2001
- AAMI Foundation Laufman Prize for Career Achievement
- 01/1993
- Made the first 2-D (C-Scan) ultrasonic images of human atherosclerotic plaques showing that calcium was responsible for the high attenuation and would likely cause shadowing in ultrasonic images (1969)
- 01/1969
- Designed a high-resolution (100 nm) tissue Doppler displacement system and measured carotid artery wall motion in mice (2004)
- Developed instrumentation and transducers for noninvasive measurement of central (1992) and regional (1996) flow velocity, and aortic pulse-wave velocity (1997) in mice
- Developed the first ultrasonic displacement (tissue Doppler) system to measure ventricular wall thickening (myocardial strain) in animals (1981) and in man (1987).
- Developed the first modular multipurpose ultrasonic system to measure regional blood flows and cardiac dimensions in large animals (1975) and in rats (1976)
- 01/1975 - 01/1976
- Developed the first 20 MHz pulsed Doppler velocimeter (1973) and catheter to measure coronary blood flow velocity (1974) and made the first measurements of coronary flow Reserve in man (1977)
- 01/1973 - 01/1977
Professional Statement
Since 1970 Dr. Hartley has been involved in the design, development, and application of ultrasonic instrumentation for cardiovascular measurements in man and in animal models of human diseases. His group designed the first high frequency (20 MHz) pulsed Doppler velocimeter and catheters to measure coronary blood flow velocity and reserve in man (1973), the first multichannel pulsed Doppler system and implantable probes to measure regional blood flow in chronically instrumented animals (1976), and the first tissue Doppler to measure ventricular wall thickening (myocardial strain) in animals (1981) and in man (1987). Since 1992, he has been developing and using similar methods noninvasively to measure blood flow velocity and arterial wall motion in mice with unprecedented precision (100 nm) and temporal resolution (100 us). His group recently showed that left main coronary flow reserve, measured noninvasively in mice, is reduced by many types of heart disease and loading and is a sensitive index of global cardiac function. The ultrasonic technology developed by Dr. Hartley's laboratory has been incorporated into many clinical and research systems.Websites
Selected Publications
- Downs LM, Bell JS, Freeman J, Hartley C, Hayward LJ, Mellersh CS "Late-onset progressive retinal atrophy in the Gordon and Irish Setter breeds is associated with a frameshift mutation in C2orf71.." Anim. Genet.. 2013 Apr;44(2):169-77. Pubmed PMID: 22686255
- Hartley CJ, Naghavi M, Parodi O, Pattichis CS, Poon CC, Zhang YT "Guest Editorial: Cardiovascular Health Informatics: Risk Screening and Intervention.." IEEE Trans Inf Technol Biomed. 2012 Sep;16(5):791-4. Pubmed PMID: 22997187
- Quaini A, Canic S, Glowinski R, Igo S, Hartley CJ, Zoghbi W, Little S "Validation of a 3D computational fluid-structure interaction model simulating flow through an elastic aperture.." J Biomech. 2012 Jan 10;45(2):310-8. Pubmed PMID: 22138194
- Lloyd EE, Crossland RF, Phillips SC, Marrelli SP, Reddy AK, Taffet GE, Hartley CJ, Bryan RM "Disruption of K2P6.1 Produces Vascular Dysfunction and Hypertension in Mice.." Hypertension. 2011 Oct;58(4):672-8. Pubmed PMID: 21876070
- Hartley CJ, Reddy AK, Madala S, Entman ML, Michael LH, Taffet GE "Doppler velocity measurements from large and small arteries of mice.." Am. J. Physiol. Heart Circ. Physiol.. 2011 Aug;301(2):H269-78. Pubmed PMID: 21572013
- Labruyere JJ, Hartley C, Holloway A "Contrast-enhanced ultrasonography in the differentiation of retinal detachment and vitreous membrane in dogs and cats.." J Small Anim Pract. 2011 Oct;52(10):522-30. Pubmed PMID: 21967099
- Yang EY, Dokainish H, Virani SS, Misra A, Pritchett AM, Lakkis N, Brunner G, Bobek J, McCulloch ML, Hartley CJ, Ballantyne CM, Nagueh SF, Nambi V "Segmental analysis of carotid arterial strain using speckle-tracking.." J Am Soc Echocardiogr. 2011 Nov;24(11):1276-1284.e5. Pubmed PMID: 21907541
- Hanasono MM, Kocak E, Ogunleye O, Hartley CJ, Miller MJ "One versus Two Venous Anastomoses in Microvascular Free Flap Surgery.." Plast. Reconstr. Surg.. 2010 Nov;126(5):1548-57. Pubmed PMID: 21042112
- Hartley CJ, Reddy AK, Madala S, Entman ML, Taffet GE "Feasibility of dual Doppler velocity measurements to estimate volume pulsations of an arterial segment.." Ultrasound Med Biol. 2010 Jul;36(7):1169-75. Pubmed PMID: 20620703
- Marciani L, Wright J, Foley S, Hoad CL, Totman JJ, Bush D, Hartley C, Armstrong A, Manby P, Blackshaw E, Perkins AC, Gowland PA, Spiller RC "Effects of a 5-HT(3) antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging.." Aliment. Pharmacol. Ther.. 2010 Sep;32(5):655-63. Pubmed PMID: 20626735
- Hartley CJ, Reddy AK, Michael LH, Entman ML, Chintalagattu V, Khakoo AY, Taffet GE "Coronary flow reserve in mice: Effects of age, coronary disease, and vascular loading.." Conf Proc IEEE Eng Med Biol Soc. 2010;1:3780-3. Pubmed PMID: 21096875
- Namiranian K, Lloyd EE, Crossland RF, Marrelli SP, Taffet GE, Reddy AK, Hartley CJ, Bryan RM "Cerebrovascular responses in mice deficient in the potassium channel, TREK-1.." Am. J. Physiol. Regul. Integr. Comp. Physiol.. 2010 Aug;299(2):R461-9. Pubmed PMID: 20357027
Memberships
- American Institute for Medical and Biological Engineering
- Fellow (01/1998)
- IEEE and EMBS
- Reg 5 Rep; Awards Chair; VP Fin (01/2006 - 01/2011)
- Biomedical Engineering Society
- Member
- Cardiovascular System Dynamics Society
- Member
- American Institute for Ultrasound in Medicine
- Member
- American Heart Association
- Member
- American Physiological Society
- Fellow
- Institute of Electrical and Electronic Engineers
- Senior Life Fellow
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