Austin L Brown
Picture
Austin L Brown
Member
Positions
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Assistant Professor
-
Pediatrics
Hematology-Oncology
Baylor College of Medicine
Houston, Texas United States
Addresses
- Baylor College of Medicine (Office)
-
One Baylor Plaza
Mail Stop: BCM 622
Houston, TX 77030
United States
Phone: (713) 798-6634
austin.brown@bcm.edu
Education
- BS from Auburn University
- 12/2009 - Auburn, Alabama United States
- Microbiology
- MPH from University of Texas Health Science Center
- 12/2011 - Houston, Texas United States
- Epidemiology
- PhD from University of Texas Health Science Center
- 05/2014 - Houston, Texas United States
- Epidemiology
- Postdoctoral Fellowship at Baylor College of Medicine
- 06/2016 - Houston, Texas United States
- Molecular Epidemiology
Honors & Awards
- Delta Omega, Honorary Society in Public Health
- University of Texas Health Science Center (05/2014)
- Young Investigator Award
- Brian Tumor Epidemiology Consortium (BTEC) (06/2015)
- Young Investigator Award
- International Society of Paediatric Oncology (SIOP) (10/2016)
Professional Interests
- Cancer Survivorship
- Childhood Cancer
- Cancer Treatment Toxicity
- Molecular Epidemiology
Websites
Selected Publications
- Brown AL, Foster KL, Lupo PJ, Peckham EC, Murray JC, Okcu MF, Lau C, Rednam S, Belmont JW, Scheurer ME "DNA methylation of a novel PAK4 locus influences ototoxicity susceptibility among cisplatin-treated survivors of pediatric embryonal tumors." Neuro Oncol. 2017 Apr 24; Pubmed PMID: 28444219
- Peckham-Gregory EC, Danysh HE, Brown AL, Eckstein O, Grimes A, Chakraborty R, Lubega J, McClain KL, Allen CE, Scheurer ME, Lupo PJ "Evaluation of maternal and perinatal characteristics on childhood lymphoma risk: A population-based case-control study." Pediatr Blood Cancer. 2017 May; Pubmed PMID: 27896915
- Banfield E, Brown AL, Peckham EC, Rednam SP, Murray J, Okcu MF, Mitchell LE, Chintagumpala MM, Lau CC, Scheurer ME, Lupo PJ "Exploratory analysis of ERCC2 DNA methylation in survival among pediatric medulloblastoma patients." Cancer Epidemiol. 2016 Oct; Pubmed PMID: 27607585
- Brown AL, Lupo PJ, Danysh HE, Okcu MF, Scheurer ME, Kamdar KY "Prevalence and Predictors of Overweight and Obesity Among a Multiethnic Population of Pediatric Acute Lymphoblastic Leukemia Survivors: A Cross-Sectional Assessment." J Pediatr Hematol Oncol. 2016 Aug; Pubmed PMID: 26989911
- Lupo PJ, Brown AL, Hettmer S "Second malignancy risk among pediatric, adolescent, and young adult survivors of fusion-positive and fusion-negative sarcomas: Results from the SEER database, 1992 through 2012." Cancer. 2016 Aug; Pubmed PMID: 27481314
- Brown AL, Lupo PJ, Okcu MF, Lau CC, Rednam S, Scheurer ME "SOD2 genetic variant associated with treatment-related ototoxicity in cisplatin-treated pediatric medulloblastoma." Cancer Med. 2015 Nov; Pubmed PMID: 26400460
- Raghubar KP, Orobio J, Ris MD, Heitzer AM, Roth A, Brown AL, Okcu MF, Chintagumpala M, Grosshans DR, Paulino AC, Mahajan A, Kahalley LS "Adaptive functioning in pediatric brain tumor survivors: An examination of ethnicity and socioeconomic status." Pediatr Blood Cancer. 2019 May 27; Pubmed PMID: 31134755
- Lupo PJ, Schraw JM, Desrosiers TA, et al. "Cancer risk among children and adolescents with birth defects: A population-based assessment of 10 million live births." JAMA Oncol. 2019 Jun 20; Pubmed PMID: 31219523
- Taylor OA, Brown AL, Brackett J, Dreyer ZE, Moore IK, Mitby P, Hooke MC, Hockenberry MH, Lupo PJ, Scheurer ME "Disparities in neurotoxicity risk and outcomes among pediatric acute lymphoblastic leukemia patients." Clin Cancer Res. 2018 Oct 15;24(20):5012-5017. Pubmed PMID: 30206159
- Lupo PJ, Brown AL, Arroyo VM, Kamdar KY, Belmont JW, Scheurer ME, Leisenring WM, Gramatges MM, Okcu MF, Yasui Y, Oeffinger KC, Robison LL, Armstrong GT, Bhatia S "DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study." Genes Chromosomes Cancer. 2019 Jan;58(1):52-59. Pubmed PMID: 30382603
- Brown AL, de Smith AJ, Gant VU, et al. "Inherited genetic susceptibility of acute lymphoblastic leukemia in Down syndrome." Blood. 2019 Jul 26; Pubmed PMID: 31350265
- Arroyo VM, Lupo PJ, Scheurer ME, Rednam SP, Murray J, Okcu MF, Chintagumpala MM, Brown AL "Pilot study of DNA methylation-derived neutrophil-to-lymphocyte ratio and survival in pediatric medulloblastoma." Cancer Epidemiol. 2019 Jan 28;59:71-74. Pubmed PMID: 30703618
- Brown AL, Arroyo VM, Agrusa JE, Scheurer ME, Gramatges MM, Lupo PJ "Survival disparities for second primary malignancies diagnosed among childhood cancer survivors: A population-based assessment." Cancer. 2019 Jun 28; Pubmed PMID: 31251393
- Richard MA, Sok P, Canon S, Brown AL, Peckham-Gregory EC, Nembhard WN, Carmichael SL, Ehli EA, Kallsen NA, Peyton SA, Davies GE, Patel A, Zamilpa I, Wyatt RA, Hobbs CA, Scheurer ME, Lupo PJ "The role of genetic variation in DGKK on moderate and severe hypospadias." Birth Defects Res. 2019 May 18; Pubmed PMID: 31102501
- Foster KL, Kern KD, Chambers TM, Lupo PJ, Kamdar KY, Scheurer ME, Brown AL "Weight trends in a multiethnic cohort of pediatric acute lymphoblastic leukemia survivors: A longitudinal analysis." PLoS One. 2019 May 31;14(5):e0217932 Pubmed PMID: 31150521
Memberships
- American Association for Cancer Research (AACR)
- Member (04/2014)
- American Society of Preventive Oncology (ASPO)
- Member (03/2015)
- International Society of Paediatric Oncology (SIOP)
- Member (10/2016)
- American College of Epidemiology (ACE)
- Associate Member (01/2017)
- Children's Oncology Group
- Member (06/2017)
Funding
- Pharmacometabolomic Biomarkers of Neuropsychological Outcomes following Pediatric Acute Lymphoblastic Leukemia Therapy
- $100,000.00 (07/01/2017 - 06/30/2018) Grant funding from Leukemia Research Foundation
- The major goal of this pilot study is to identify novel biomarkers of chemotherapy-induced neurocognitive impairment among pediatric ALL patients.
- Genetic Determinants of Neuropsychological Performance Following Treatment for Pediatric Embryonal Brain Tumors
- $50,000.00 (08/01/2017 - 07/31/2018) Grant funding from Pablove Foundation
- The major goal of this project is to identify genetic modifiers of therapy-related neurocognitive decline in a prospective cohort of pediatric brain tumor patients treated with cranial radiation therapy.
- Integrative Molecular Epidemiology of Neurocognitive Outcomes in Acute Lymphoblastic Leukemia - #K07CA218362
- $756,746.00 (04/11/2017 - 03/31/2023) Grant funding from National Cancer Institute
- The research objectives of this career development award are to: 1) evaluate the association between patient reported symptoms during childhood leukemia treatment on post-treatment neurocognitive performance, and 2) evaluate potential biomarkers of neurocognitive complications.
- Multi-omic Biomarker Discovery for Therapy-related Neurocognitive Impairment in Childhood Acute Lymphoblastic Leukemia - #RP190132
- $1,187,006.00 (03/01/2019 - 02/28/2023) Grant funding from Cancer Prevention and Research Institute of Texas
- The goal of this project is to assemble a overlapping prospective cohorts of childhood leukemia patients and survivors to explore trajectories in neurocognitive performance and evaluate potential drivers of disparities in cognitive outcomes.
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