Atul Chopra, M.D., Ph.D.
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Atul Chopra, M.D., Ph.D.
Caroline Wiess Law Scholar, Assistant Professor
Positions
- Caroline Wiess Law Scholar, Assistant Professor
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Molecular and Human Genetics, Molecular and Cellular Biology
Baylor College of Medicine
Houston, TX
- Attending Physician
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Pediatric Genetics Clinic
Texas Children's Hospital
Houston, TX
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- 1 Baylor Plaza (Office)
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DeBakey M824
Houston, TX 77030
United States
- 1 Baylor Plaza (Lab)
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DeBakey M825/CHOPRA
Houston, TX 77030
United States
- Texas Children's Hospital (Clinic)
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6701 Fannin Street
Houston, TX 77030
United States
Education
- MD from MIMER Medical College
- 01/2003 - Pune, India
- PhD from Baylor College of Medicine
- 06/2010 - Houston, Texas United States
- Molecular and Cellular Biology
- Internship at Baylor College of Medicine
- 06/2011 - Houston, Texas
- Medicine/Pediatrics
- Residency at Baylor College of Medicine
- 07/2014 - Houston, Texas
- Medical Genetics
Certifications
- Clinical Genetics
- American Board of Medical Genetics and Genomics
Professional Interests
- Energy and metabolic homeostasis, asprosin biology, identification of novel disorders of energy balance in humans
Professional Statement
I am a physician-scientist at Baylor College of Medicine with clinical expertise in Medical Genetics and research expertise in the field of energy homeostasis and metabolic disease. Through the assessment of humans with genetic defects in the processing of energy, we are able to identify new genes and pathways that have escaped attention so far. This not only benefits patients but also allows us to take the discovery into the lab and focus on filling in the gap from the gene to the phenotype. The overarching aim is to help one patient at a time but also a broader swath of humanity via advancing medical knowledge and developing novel therapeutics. As an example of this, by studying a rare genetic disorder - Neonatal Progeroid Syndrome, our lab was the first to identify a novel hormone (that we named asprosin) that modulates hepatic glucose production and appetite stimulation using spatiotemporally distinct mechanisms when dietary fuel is unavailable. In the therapeutic arena, antibodies targeting asprosin are showing considerable promise by acutely lowering blood glucose and appetite, leading over the long term to improvement in type II diabetes and obesity respectively.Selected Publications
- Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR "Asprosin is a centrally acting orexigenic hormone." Nature Medicine. 2017 Nov 6;23(12):1444-1453. Pubmed PMID: 29106398
- Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha PK, Del Solar M, Zhu B, York B, Sarkar P, Rendon DA, Gaber MW, LeMaire SA, Coselli JS, Milewicz DM, Sutton VR, Butte NF, Moore DD, Chopra AR "Asprosin, a Fasting-Induced Glucogenic Protein Hormone." Cell. 2016 Apr 21;165(3):566-579. Pubmed PMID: 27087445
- Chopra AR*, Louet JF*, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW "Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke’s Disease." Science. 2008 Nov 28;322(5906):1395-9. Pubmed PMID: 19039140
- Chopra AR, Kommagani R, Saha P, Song J, Jeong JW, Louet JF, Salazar C, Finegold M, Viollet B, Demayo F, Chan L, Moore D, O'Malley BW "Cellular Energy Depletion Resets Whole-Body Energy by Promoting Coactivator Mediated Dietary Fuel Absorption." Cell Metabolism. 2011 Jan 5;13(1):35-43. Pubmed PMID: 21195347
- Louet JF*, Chopra AR*, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, Demayo F, Xu J, Newgard CB, O'Malley BW "The Coactivator SRC-1 is an Essential Coordinator of Hepatic Glucose Production." Cell Metabolism. 2010 Dec 1;12(6):606-18. Pubmed PMID: 21109193
- Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH "Foxa2-Dependent Hepatic Gene Regulatory Networks Depend on Physiological State." Physiol Genomics. 2009 Jul 9;38(2):186-95. Pubmed PMID: 19417011
- York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW "Ablation of Steroid Receptor Coactivator-3 Resembles the Human CACT Metabolic Myopathy." Cell Metabolism. 2012 May 2;15(5):752-63. Pubmed PMID: 22560224
Funding
- Caroline Wiess Law Scholar Award for Academic Excellence (06/01/2015 Unrestricted funding from The Caroline Wiess Law Endowment
- Chao Physician-Scientist Award (06/01/2014 - 06/01/2015) Unrestricted funding from The Ting Tsung and Wei Fong Chao Foundation
- Clinical Scientist Development Award (K08) - #1K08DK102529 (07/01/2014 - 07/01/2019) Grant funding from The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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