Amos Solomon Gaikwad, M.S., Ph.D.
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Positions
- Assistant Professor
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Pediatrics-Hema & Oncology
Baylor College of Medicine
Houston, TX US
- Instructor
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Pediatrics
Hematology Oncology
Baylor College of Medicine
Houston, Texas United States
- Instructor
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Molecular Therapeutics
Cancer Medicine
M D Anderson Cancer Center
Houston, Texas United States
- Postdoctoral Associate
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Pharmacology
Baylor College of Medicine
Houston, Texas United States
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Texas Children's Hosptial (Office)
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Feigin Building
Suite 1130
Houston, TX 77030
United States
Phone: (832) 824-4814
axgaikwa@txch.org
Education
- MS from Pune University
- 04/1986 - Pune, Maharashtra India
- Ph.D. from Indian Institute Of Science
- 01/1991 - Bangalore, India
Websites
Selected Publications
- Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT "A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia.." Haematologica. 2006 Nov;91(11):1542-5. Pubmed PMID: 17082011
- Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU "A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase.." Cell Death Differ.. 2007 Nov;14(11):1948-57. Pubmed PMID: 17690712
- Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M "Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells.." J. Invest. Dermatol.. 2008 Nov;128(11):2728-35. Pubmed PMID: 18496567
- Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M. "Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells.." J Invest Dermatol. 2008 Nov;128(11):2728-35. Pubmed PMID: 18496567
- Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL "Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells.." J. Immunol.. 2010 Apr 15;184(8):4557-67. Pubmed PMID: 20220088
- Gaikwad A, Bonifant CL, Cubbage M, Goltsova T, Mudannayake M, Ringrose J, Punia J, Lopez-Terrada D, Sheehan AM. "Detection of Lymphoid and Myeloid Lineages in Infantile B Acute Lymphoblastic Leukemia with Mixed Lineage Leukemia Rearrangement by Use of Flow Cytometry and Cytogenetics.." Clin Lymphoma Myeloma Leuk. 2014 Sep 14;Suppl; S2-5. Pubmed PMID: 25486951
- Long DJ, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK "Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.." J. Biol. Chem.. 2002 Nov 29;277(48):46131-9. Pubmed PMID: 12351651
- Gutterman JU, Lai HT, Yang P, Haridas V, Gaikwad A, Marcus S "Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast.." Proc. Natl. Acad. Sci. U.S.A.. 2005 Sep 6;102(36):12771-6. Pubmed PMID: 16118282
- Gaikwad AS, Donohue RE, Elghetany MT, Sheehan AM, Lu XY, Gramatges MM, McClain KL, Mistretta TA, Punia JN, Moore TJ, Goltsova T, Cubbage M, Curry CV. "Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia.." Int J Clin Exp Pathol. 2014 Aug 15;7(9):6225-30.. Pubmed PMID: 25337274
- Gaikwad A, Verstovsek S, Yoon D, Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, Prchal JT "Imatinib effect on growth and signal transduction in polycythemia vera.." Exp. Hematol.. 2007 Jun;35(6):931-8. Pubmed PMID: 17533047
- Gaikwad A, Nussenzveig R, Liu E, Gottshalk S, Chang K, Prchal JT "In vitro expansion of erythroid progenitors from polycythemia vera patients leads to decrease in JAK2 V617F allele.." Exp. Hematol.. 2007 Apr;35(4):587-95. Pubmed PMID: 17379069
- Gaikwad A, Long DJ, Stringer JL, Jaiswal AK "In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue.." J. Biol. Chem.. 2001 Jun 22;276(25):22559-64. Pubmed PMID: 11309386
- Iskander K, Gaikwad A, Paquet M, Long DJ, Brayton C, Barrios R, Jaiswal AK "Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis.." Cancer Res.. 2005 Mar 15;65(6):2054-8. Pubmed PMID: 15781611
- Agarwal N, Kutlar F, Mojica-Henshaw MP, Ou CN, Gaikwad A, Reading NS, Bailey L, Kutlar A, Prchal JT "Missense mutation of the last nucleotide of exon 1 (G->C) of beta globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele.." Haematologica. 2007 Dec;92(12):1715-6. Pubmed PMID: 18056002
- Nussenzveig RH, Swierczek SI, Jelinek J, Gaikwad A, Liu E, Verstovsek S, Prchal JF, Prchal JT "Polycythemia vera is not initiated by JAK2V617F mutation.." Exp. Hematol.. 2007 Jan;35(1):32-8. Pubmed PMID: 17198871
- Quintás-Cardama A, Manshouri T, Estrov Z, Harris D, Zhang Y, Gaikwad A, Kantarjian HM, Verstovsek S "Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor.." Invest New Drugs. 2011 Oct;29(5):818-26. Pubmed PMID: 20372971
- Stringer JL, Gaikwad A, Gonzales BN, Long DJ, Marks LM, Jaiswal AK "Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system.." J. Comp. Neurol.. 2004 Apr 5;471(3):289-97. Pubmed PMID: 14991562
- Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR "Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.." Br. J. Haematol.. 2009 Mar;144(6):930-2. Pubmed PMID: 19120350
- Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR. "Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia.." Br J Haematol. 2009 Mar;144(6):930-2. Pubmed PMID: 19120350
- Gaikwad A, Prchal JT "Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera.." Exp. Hematol.. 2007 Nov;35(11):1647-56. Pubmed PMID: 17976517
- Manshouri T, Quintás-Cardama A, Nussenzveig RH, Gaikwad A, Estrov Z, Prchal J, Cortes JE, Kantarjian HM, Verstovsek S "The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation.." Cancer Sci.. 2008 Jun;99(6):1265-73. Pubmed PMID: 18482053
- Gaikwad AS, Cumsky MG "The use of chemical cross-linking to identify proteins that interact with a mitochondrial presequence.." J. Biol. Chem.. 1994 Mar 4;269(9):6437-43. Pubmed PMID: 8119994
- Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, Narog M, Spears E, Zoltaszek R, Walaszek Z, Gutterman JU "Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery.." J. Clin. Invest.. 2004 Jan;113(1):65-73. Pubmed PMID: 14702110
- Gaikwad A, Poblenz A, Haridas V, Zhang C, Duvic M, Gutterman J "Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity.." Clin. Cancer Res.. 2005 Mar 1;11(5):1953-62. Pubmed PMID: 15756021
Skills
- Flow Cytometry
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