The emergency department is often the first location children with newly-diagnosed diabetes or those with complications from their diabetes, including diabetic ketoacidosis (DKA), receive care. In partnership with colleagues in the Pediatric Emergency Care Applied Research Network (PECARN), Texas Children's Hospital and BCM prospectively enrolled children in a clinical trial to determine the association between fluid composition and volume in correcting DKA and preventing the cognitive sequelae that can be seen with individual and repetitive episodes of DKA.
Faculty with a research focus on endocrinology
- Julie McManemy, M.D., MSPH: fluid resuscitation in children in diabetic ketoacidosis
- Email: Julie.McManemy@bcm.edu
Trainor JL, Glaser NS, Tzimenatos L, Stoner MJ, Brown KM, McManemy JK, Schunk JE, Quayle KS, Nigrovic LE, Rewers A, Myers SR, Bennett JE, Kwok MY, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Team. Clinical and laboratory predictors of dehydration severity in children with diabetic ketoacidosis. Ann Emerg Med. 2023. PMID 37024382.
Ghetti S, Kuppermann N, Rewers A, Myers SR, Schunk JE, Stoner MJ, Garro A, Quayle KS, Brown KM, Trainor JL, Tzimenatos L, DePiero AD, McManemy JK, Nigrovic LE, Kwok MY, Olsen CS, Casper TC, Glaser NS; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Team. Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes. Endocrinol Diabetes Metab. 2023. PMID 36788736.
Glaser NS, Stoner MJ, Kwok MY, Quayle KS, Brown KM, Schunk JE, Trainor JL, McManemy JK, Tzimenatos L, Rewers A, Nigrovic LE, Bennett JE, Myers SR, Smith M, Casper TC, Kuppermann N. Relationships among biochemical measures in children with diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2023. PMID 36637392.
Glaser NS, Quayle KS, McManemy JK, Nigrovic LE, Tzimenatos L, Stoner MJ, Bennett JE, Trainor JL, Rewers A, Schunk JE, Myers SR, Kwok MY, Brown KM, Gheetti S, Casper TC, Olsen CS, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Team. Clinical characteristic of children with cerebral injury preceding treatment of diabetic ketoacidosis. J Pediatr. 2022; PMID 35944716. 8/6/22.
Glaser NS, Stoner MJ, Garro A, Baird S, Myers SR, Rewers A, Brown KM, Trainor JL, Quayle KS, McManemy JK, et al. Serum sodium concentration and mental status in children with diabetic ketoacidosis. Pediatrics. 2021;148(3):e2021050243. E_pub 9/9/21. PMID 34373322.
Rewers A, Kuppermann N, Stoner MJ, Garro A, Bennett JE, Quayle KS, Schunk JE, Myers SR, McManemy JK, et al. Effects of fluid rehydration strategy on correction of acidosis and electrolyte abnormalities in children with diabetic ketoacidosis. Diabetes Care. 2021;44(9):2061-2068. E-pbu /29/21. PMID 34187840.
Myers SR, Glaser NS, Trainor JL, Nigrovic LE, Garro A, Tzimenatos L, Quayle KS, Kwok MY, Rewers A, Stoner MJ, Schunk JE, McManemy JK, Brown KM, DePiero AD, Olsen CS, Casper TC, Ghetti S, Kuppermann N; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group. Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes. JAMA Netw Open. 2020. PMID: 33275152.
Ghetti S, Kuppermann N, Rewers A, Myers SR, Schunk JE, Stoner MJ, Garro A, Quayle KS, Brown KM, Trainor JL, Tzimenatos L, DePiero AD, McManemy JK, Nigrovic LE, Kwok MY, Perry CS 3rd, Olsen CS, Casper TC, Glaser NS; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group. Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes. Diabetes Care. 2020. PMID: 32962981.
DePiero A, Kuppermann N, Brown KM, Schunk JE, McManemy JK, Rewers A, Stoner MJ, Tzimenatos L, Garro A, Myers SR, Quayle KS, Trainor JL, Kwok MY, Nigrovic LE, Olsen CS, Casper TC, Ghetti S, Glaser NS; Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group. Hypertension during Diabetic Ketoacidosis in Children. J Pediatr. 2020. PMID: 32387716.
