Theodore Wensel Lab

Master
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About the Lab

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The Wensel Lab research includes the following areas:

  • Visual transduction
  • G protein pathways and proteins that regulate them in the retina and the brain
  • RGS proteins: GAPs for heterotrimeric G proteins
  • Biomembranes
  • Ocular Proteomics
  • Cryo-electron microscopy and tomography
  • Gene repair in neurons
  • Phosphoinositide signaling
  • Super resolution fluorescence microscopy
  • Gene engineering in mice and frogs
  • TRP Channels
  • Primary cilia and retinal ciliopathies
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Dosey et al., 2018, Nature Structural and Molecular Biology
Ribbon diagram of side view, and space-filling model of view from outside cell of TRPV2 an important cation channel required for autoregulation of blood flow.
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Structure of cation channel TRPV2 in open state

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TWFig3D2Rmut
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Enhanced Serotonin Responses in Dopamine Receptor Mutants

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Serotonin responses of dopamine receptors engineered by evolution-guided mutagenesis.

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TWFig1RGS9loc
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Localization of RGS9-2

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Localization of RGS9-2, a regulator of G-protein coupled receptors, in cultured striatal neurons.

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Wensel et al., Progress in Retinal and Eye Research, 2016.
3D structure of a daughter centriole from a mouse rod sensory cilium, determined by cryo-electron tomography and sub-tomogram averaging.
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3D structure of daughter centriole by cryo-ET

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Cryo-electron tomography and sub-tomogram averaging was used to determine 3D structure of a daughter centriole from a mammalian rod sensory cilium.