Chagas Disease Vaccine

Chagas disease (American trypanosomiasis caused by Trypanosoma cruzi), transmitted by triatomines (kissing bugs), affects by some estimates as many as 9-10 million people around the world. In total, combining years of life lost and years lived with disability, Chagas disease causes the loss of approximately 0.6 million disability-adjusted life years, a measure integrating a disease’s morbidity and mortality.

A unique product development partnership seeks to address the need for new therapeutics for Chagas disease by developing and testing vaccine candidate antigens that would eventually comprise a multivalent therapeutic vaccine. One of the components of this vaccine will likely be a unique T. cruzi 24 kDa antigen, Tc24, which is being prepared for clinical testing in Mexico.

As the final product, we envision a stand-alone product to halt the progression of Chagas disease, or a complimentary therapy that will bridge the tolerability and efficacy gaps of current chemotherapy, ultimately delaying or halting the progression of chagasic cardiomyopathy.

In addition, we are investigating other protein and mRNA vaccine antigens in pre-clinical animal models.