Jin Wang Lab

Master
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Dr. Jin Wang
Quantitative Real-Time Imaging of Glutathione in Living Cells
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Quantitative Real-Time Imaging of Glutathione Dynamics
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We developed a glutathione (GSH) probe—RealThiol—that allows real-time monitoring of GSH dynamics in living cells (Nature Communications 2017).

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Jin Wang
Global distribution of GSH probes developed by the Jin Wang group. The GSH probes, including RealThiol (RT) and Mito-RealThiol (Mitro-RT) probes, have been distributed to over 50 institutions worldwide through either MTAs or Kerafast.com.
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Impact of Our GSH Probes

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Global distribution of GSH probes developed by our group. The GSH probes, including RealThiol (RT) and Mito-RealThiol (Mito-RT) probes, have been distributed to over 50 institutions worldwide through either material transfer agreements (MTAs) or Kerafast.com. The map is updated on Dec 27, 2018.

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Targeting SRC-3 shuts down many cancer signaling pathways simultaneously
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Steroid Receptor Coactivator 3 (SRC-3) Small Molecule Inhibitors

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We developed a small molecule inhibitor that can inhibitor SRC-3 and impact many cancer signaling pathways simultaneously (PNAS 2016).

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About the Lab

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We are a highly interdisciplinary group and interested in developing tools for biological and biomedical studies. Currently, our research is mainly focused in three areas:

  • Developing novel fluorescent probes to quantitatively monitor real-time glutathione dynamics in living cells
  • Developing small molecule inhibitor against coactivators to treat breast cancer
  • Developing antibody drug conjugates as novel cancer therapies