Chemical Suppression of Neuroma Formation and Associated Effect on HO

Our previous studies have demonstrated the role of neuroinflammation in BMP2-induced HO. Part of this process is the activation of β3- adrenergic receptor-expressing cells in the perineurium of the peripheral nerves, which causes their replication, mitochondrial expansion, and subsequent formation of a peripheral nerve neuroma.

This current project has identified a few potential drug candidates for the inhibition of this process by blocking either the activation of β3- adrenergic receptor or by interfering with other stages like mast cell degranulation.

Our lab is currently investigating how the suppression of this neuroinflammatory process affects the bone formation typically achieved in our model of BMP2-induced HO.