Scott A. LeMaire, MD, FACS, FAHA, FCCP
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Scott A. LeMaire, MD, FACS, FAHA, FCCP
Professor and Vice-Chair for Research
Positions
- Professor and Vice-Chair for Research
-
Surgery
Cardiothoracic Surgery
Baylor College of Medicine
- Professor
-
Molecular Physiology & Biophysics
Baylor College of Medicine
- Director of Research
-
Division of Cardiothoracic Surgery
Baylor College of Medicine
- Jimmy and Roberta Howell Professorship in Cardiovascular Surgery
-
Baylor College of Medicine
Addresses
- Baylor College of Medicine Medical Center (Clinic)
-
McNair Campus
7200 Cambridge Street
Houston, TX 77030
United States
Phone: (713) 798-6376
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Education
- B.S. from Quincy College
- 01/1988 - Quincy, IL United States
- M.D. from Northwestern University Medical School
- 01/1992 - Chicago, IL United States
- General Surgery Residency from Baylor College Of Medicine
- 01/1997 - Houston, TX United States
- Thoracic Surgery Residency from Baylor College Of Medicine
- 01/1999 - Houston, TX United States
- Graduate Certificate at Baylor College of Medicine
- 05/2006 - Houston
- Clinical Scientist Training Program (CAQ)
Certifications
- Board Certified
- American Board of Thoracic Surgery
Honors & Awards
- Michael E. DeBakey, M.D., Excellence in Research Award
- BCM (07/2014)
- Thoracic Surgery Foundation for Research and Education Alley-Sheridan Scholarship
- Thoracic Surgery Foundation for Research and Education (01/2013)
- Distinguished Scientist Award
- St. Luke’s Episcopal Hospital (12/2011)
- Elected President
- Association for Academic Surgery (02/2011 - 02/2012)
- Elected Secretary
- Association for Academic Surgery (02/2008 - 02/2010)
- The First Association for Academic Surgery International Visiting Professorship Award
- Association for Academic Surgery (08/2007)
- DeBakey Distinguished Service Award
- Michael E. DeBakey Department of Surgery, BCM (06/2017)
- The James E. Thompson Award for Best Paper by a New Member
- Thoracic aortic aneurysms after dissection: evidence supporting proteolytic mechanisms
- Texas Surgical Society (10/2004)
- Fulbright & Jaworski L.L.P. Faculty Excellence Award
- Baylor College of Medicine (05/2016)
- Jimmy and Roberta Howell Professorship in Cardiovascular Surgery
- Baylor College of Medicine (04/2018)
- AATS Cardiac Surgery Biology Club Cup
- American Association for Thoracic Surgery (04/2018)
- Editor-in-Chief
- Journal of Surgical Research (02/2015)
- Appointed Chair, Literature Selection Technical Review Committee
- National Library of Medicine (06/2020 - 06/2021)
Professional Interests
- Surgical treatment for hyperhidrosis/excessive sweating of palms or axilla
- Aortic surgery
- Ascending aortic replacement
- Aortic arch replacement
- Heart valve repair and replacement
- Thoracoabdominal aortic aneurysm repair
- Aortic dissection
- Aortic root replacement
- Marfan syndrome
Professional Statement
Scott A. LeMaire, M.D., is the Jimmy and Roberta Howell Professor of Cardiovascular Surgery, the Vice Chair for Research in the Michael E. DeBakey Department of Surgery, the Director of Research in the Division of Cardiothoracic Surgery, and Professor of Molecular Physiology and Biophysics at Baylor College of Medicine, as well as a member of the professional staff in the Department of Cardiovascular Surgery at the Texas Heart Institute and Baylor St. Luke’s Medical Center in Houston, Texas. Dr. LeMaire graduated from Northwestern University Medical School in 1992 and completed residency training in cardiothoracic surgery at Baylor College of Medicine in 1999. His primary clinical interest focuses on the management of patients with thoracic aortic disease, with a particular emphasis on the treatment of aortic dissection and thoracoabdominal aortic aneurysms. His corresponding research program focuses on organ protection during aortic surgery, genetic aspects of thoracic aortic disease, and molecular mechanisms of aortic degeneration. He has received funding from the National Institutes of Health (NIH), the American Heart Association (AHA), and the Thoracic Surgery Foundation for his research studying the pathobiology of thoracic aortic aneurysms and aortic dissection. At Baylor, he has received both the Michael E. DeBakey Excellence in Research Award and the Fulbright & Jaworski Faculty Excellence Award for Teaching and Evaluation, among the most prominent awards in research and education given by the College. Dr. LeMaire is a past-president of the Association for Academic Surgery and is the current editor-in-chief of the Journal of Surgical Research.In addition to his clinical interest in aortic disease, Dr. LeMaire’s clinical practice focuses on offering minimally invasive endoscopic thoracic sympathectomy to treat patients with hyperhidrosis who suffer from excessive sweating of the palms and/or axilla. This safe and highly effective outpatient procedure can provide patients with immediate relief from symptoms.
Dr. LeMaire’s basic science laboratory research—conducted in the Aortic Disease Research Lab—is currently focusing on the role of various aspects of extracellular matrix metabolism in the development of aortic aneurysms and dissections. In particular, his group is studying the roles of destructive factors, such as inflammatory cells and proteases, as well as reparative mechanisms, such as stem cell recruitment and transformation, during the development of aortic aneurysms and dissections. His lab performed novel experiments demonstrating that ciprofloxacin, a commonly prescribed fluoroquinolone antibiotic, causes severe damage to the aortic wall in susceptible mice, supporting that these drugs should be avoided in patients with or at risk for aortic aneurysms or dissections. Furthermore, his research team has conducted several studies to evaluate the safety profile of surgical adhesives, which are an important adjunct for limiting bleeding complications during aortic repairs.
In 2002, his research group initiated the Thoracic Aortic Disease Tissue Bank, which currently houses samples and corresponding phenotypic data from over 4,000 patients with thoracic aortic disease. The tissue bank has served as a core for the NIH-supported Specialized Center of Clinically Oriented Research in Thoracic Aortic Aneurysms and Dissection as well as a resource for numerous collaborative studies evaluating the genetic factors and molecular mechanisms involved in the development of thoracic aortic disease.
Through an AHA Strategically Focused Vascular Research Network Award, the lab has established the Aortopathy Research Center in partnership with collaborators at the University of Kentucky College of Medicine. The goal of this project is to understand how different types of cells in the aortic wall respond to stress and how these responses differ in men and women.
Websites
Follow Dr. LeMaire on Twitter
Selected Publications
- LeMaire SA, Miller CC, Conklin LD, Schmittling ZC, Köksoy C, Coselli JS "A new predictive model for adverse outcomes after elective thoracoabdominal aortic aneurysm repair." Ann Thorac Surg. 2001 Apr;71(4):1233-8. Pubmed PMID: 11308166
- Shen YH, Zhang L, Ren P, Nguyen MT, Zou S, Wu D, Wang XL, Coselli JS, LeMaire SA "AKT2 Confers Protection Against Aortic Aneurysms and Dissections." Circ Res. 2013 Feb 15;112(4):618-32. Pubmed PMID: 23250987
- Coselli JS, LeMaire SA, Köksoy C, Schmittling ZC, Curling PE "Cerebrospinal fluid drainage reduces paraplegia after thoracoabdominal aortic aneurysm repair: results of a randomized clinical trial." J. Vasc. Surg.. 2002 Apr;35(4):631-9. Pubmed PMID: 11932655
- LeMaire SA, McDonald ML, Guo DC, Russell L, Miller CC, Johnson RJ, Bekheirnia MR, Franco LM, Nguyen M, Pyeritz RE, Bavaria JE, Devereux R, Maslen C, Holmes KW, Eagle K, Body SC, Seidman C, Seidman JG, Isselbacher EM, Bray M, Coselli JS, Estrera AL, Safi H "Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.." Nat. Genet.. 2011;43(10):996-1000. Pubmed PMID: 21909107
- LeMaire SA, Jones MM, Conklin LD, Carter SA, Criddell MD, Wang XL, Raskin SA, Coselli JS "Randomized comparison of cold blood and cold crystalloid renal perfusion for renal protection during thoracoabdominal aortic aneurysm repair." J Vasc Surg. 2009 Jan;49(1):11-9. Pubmed PMID: 19028052
- Köksoy C, LeMaire SA, Curling PE, Raskin SA, Schmittling ZC, Conklin LD, Coselli JS "Renal perfusion during thoracoabdominal aortic operations: cold crystalloid is superior to normothermic blood." Ann Thorac Surg. 2002 Mar;73(3):730-8. Pubmed PMID: 11899174
- LeMaire SA, Carter SA, Volguina IV, Laux AT, Milewicz DM, Borsato GW, Cheung CK, Bozinovski J, Markesino JM, Vaughn WK, Coselli JS "Spectrum of aortic operations in 300 patients with confirmed or suspected Marfan syndrome." Ann Thorac Surg. 2006 Jun;81(6):2063-78; discus. Pubmed PMID: 16731131
- Lemaire SA "Association for Academic Surgery presidential address: Toward self-actualization in academic surgery." J Surg Res. 2012 Nov;178(1):41281. Pubmed PMID: 22947698
- LeMaire SA, Zhang L, Luo W, Ren P, Azares AR, Wang Y, Zhang C, Coselli JS, Shen YH "Effect of ciprofloxacin on susceptibility to aortic dissection and rupture in mice.." JAMA Sure. 2018;153::e181804.
- Wu D, Ren P, Zheng Y, Zhang L, Xu G, Xie W, Lloyd EE, Zhang S, Zhang Q, Curci JA, Coselli JS, Milewicz DM, Shen YH, LeMaire SA. "NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3)–caspase-1 inflammasome degrades contractile proteins: implications for aortic biomechanical dysfunction and aneurysm and dissection formation.." Arterioscler Thromb Vasc Biol. 2017;37:694-706.
- Coselli JS, LeMaire SA, Preventza O, de la Cruz KI, Cooley DA, Price MD, Stolz AP, Green SY, Arredondo CN, Rosengart TK "Outcomes of 3309 thoracoabdominal aortic aneurysm repairs." J Thorac Cardiovasc Surg. 2016;151:1323-38.
- Luo W, Wang Y, Zhang L, Ren P, Zhang C, Li Y, Azares AR, Zhang M, Guo J, Ghaghada KB, Starosolski ZA, Rajapakshe K, Coarfa C, Li Y, Chen R, Fujiwara K, Abe J, Coselli JS, Milewicz DM, LeMaire SA, Shen YH "Critical role of cytosolic DNA and its sensing adaptor STING in aortic degeneration, dissection, and rupture." Circulation. 2020;141:42-66.
Memberships
- Michael E. DeBakey International Surgical Society
- Board of Directors
- American College of Surgeons
- Fellow
- American Surgical Association
- Fellow
- National Marfan Foundation
- Clinical Council
- Society of Thoracic Surgeons
- Texas Medical Association
- Harris County Medical Society
- American Heart Association
- Fellow
- International Society for Applied Cardiovascular Biology
- Association for Academic Surgery
- Past-President
- Houston Surgical Society
- American College of Chest Physicians
- Fellow
- American Association for Thoracic Surgery
- Denton A. Cooley Cardiovascular Surgical Society
- Society of University Surgeons
- Cooley Hands
- Honorary Member
- Surgical Outcomes Club
- Society for Vascular Surgery
- Texas Surgical Society
- President-Elect
- Southern Thoracic Surgical Association
- European Association for Cardio-Thoracic Surgery
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