Positions
- Professor
-
University of Washington
- Adjunct Professor
-
Baylor College of Medicine
Addresses
- N326 (Office)
-
Mailstop 358056
Seattle, WA 98109
United States
Phone: (206) 543-6551
xin18@uw.edu
Education
- Post-Doctoral Fellowship at University of California, Los Angeles
- 07/2008 - Los Angeles, CA United States
- PhD from Shanghai Institute of Biochemistry and Cellular Biology, Chinese Academy of Sciences
- 07/2001 - Shanghai, China
- BS from Nanjing University
- 07/1996 - Nanjing, Jiangsu China
Professional Interests
- Prostate stem cells, development and carcinogenesis.
Professional Statement
My lab is interested in using the prostate as a tissue model to study the molecular and cellular mechanisms that regulate development, tissue homeostasis and carcinogenesis. Currently, there are two major research focuses in the lab. The first research focus is to characterize the prostate epithelial lineage hierarchy. We seek to investigate how individual prostate epithelial lineages are maintained in adults by prostate stem cells or progenitors, and to identify master regulators that control adult prostate homeostasis. The second focus of the lab is to investigate the molecular and cellular basis of aggressive prostate cancer. We are interested in determining the function of disease-associated genes in prostate cancer initiation and progression, and characterizing the identity of the cells of origin for prostate cancer. The major approaches that we utilize are cell culture-based prostate stem cell assays, genetically engineered mouse models, and a prostate regeneration method.I have relocated my laboratory to the University of Washington at Seattle since August 1, 2018. https://www.washington.edu/urology/people/li-xin-ph-d/.
Websites
Selected Publications
- Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L "Notch and TGFß Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity.." Cell Stem Cell. 2012 Nov 2;11(5):676-88. Pubmed PMID: 23122291
- Choi N, Zhang B, Zhang L, Ittmann M, Xin L "Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation.." Cancer Cell. 2012 Feb 14;21(2):253-65. Pubmed PMID: 22340597
- Kwon O, Zhang L, Ittmann and Xin L "Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin.." Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E592-600. Pubmed PMID: 24367088
- Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L "Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.." Nature Communications. 2014 Jul 22;5:4416. Pubmed PMID: 25048699
- Kwon O, Zhang L, Wang J, Su Q, Feng Q, Zhang X, Mani SA, Paulter R, Creighton CJ, Ittmann MM and Xin L "Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.." Journal of Clinical Investigation. 2016 Jul 1;126(7):2626-41.
- Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj G, Mauck R, Roehrborn C, Creighton CJ, Strand DW, Ittmann MM, and Xin L "Non-cell-autonomous regulation of prostate epithelial homeostasis by androgen receptor." Molecular Cell. 2016 Sep 15;63(6) Pubmed PMID: 27594448
- Xin L "Cells-of-origin for cancer: an updated view from prostate cancer." Oncogene. 2013 Aug 8;32(32):3655-63. Pubmed PMID: 23178496
- Qingtai Su, Boyu Zhang, Li Zhang, Truong Dong, David Rowley, Michael Ittmann, and Li Xin "Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer.." Oncogene. 2016 Jun 27;
- Zhang B, Chen H, Zhang L, Dakhova A, Zhang Y, Creighton C, Lewis M, Ittmann M, Xin L "A dosage dependent pleiotropic role of Dicer in prostate cancer growth and metastasis.." Oncogene. 2014 Jun 12;33(24):3099-108. Pubmed PMID: 23851498
- Oh-Joon Kwon, Li Zhang, and Li Xin "Stem Cell Antigen-1 Identifies a Distinct Androgen-Independent Murine Prostatic Luminal Cell Lineage with Bipotent Potential.." Stem Cells. 2016 Jan 3;34(1):192-202. Pubmed PMID: 4816225
- Zhang L, Zhang B, Valdez JM, Wang F, Ittmann M, Xin L "Dicer ablation impairs prostate stem cell activity and causes prostate atrophy.." Stem Cells. 2010 Jul;28(7):1260-9. Pubmed PMID: 20517984
- Zhang L, Valdez JM, Zhang B, Wei L, Chang J, Xin L "ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency.." PLoS ONE. 2011;6(3):e18271. Pubmed PMID: 21464902
- Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L "Low-density Taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells.." Prostate. 2010 Feb 15;70(3):297-304. Pubmed PMID: 19827049
- Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, Demayo FJ, Xin L "Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis.." Transgenic Research. 2012 Oct 15;21(5):1117-23. Pubmed PMID: 22350718
- Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM "Wnt and notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation.." Stem Cells. 2011 Apr;29(4):678-88. Pubmed PMID: 21308863
- Xin L "A developmental stage-dependent switch of the mechanisms for prostate epithelial maintenance.." Asian J. Androl.. 2013 Jan;15(1):85-6. Pubmed PMID: 23223032
Memberships
- American Association of Cancer Research
- Society of Basic Urological Research
- International Society for Stem Cell Research
Funding
- The prostate epithelial cell lineage hierarchy - #R01DK092202 Grant funding from NIH/NIDDK
- The Notch signaling in prostate homeostasis and carcinogenesis - #R01CA190378 Grant funding from NIH/NCI
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