Joseph Michael Hyser, Ph.D.
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Positions
- Assistant Professor
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Virology & Microbiology
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- BCM-Jewish Wing (Lab)
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Room: BCM-824D
Houston, TX 77030
United States
Phone: (713) 798-4514
joseph.hyser@bcm.edu
Education
- Post-doctoral Training from Baylor College Of Medicine
- 01/2010 - Houston, TX United States
- Viroporins, Rotavirus
- Ph.D. from Baylor College Of Medicine
- 01/2007 - Houston, TX United States
- BA from Augustana College
- 05/1999 - Rock Island, IL United States
- Biology, Philosophy
Honors & Awards
- 1st Place Predoctoral Poster Presentation
- Molecular Virology & Microbiology Retreat (11/2003)
- 1st place Post-doctoral Oral Presentation
- Molecular Virology & Microbiology Retreat (12/2007)
- 1st place Post-doctoral Oral Presentation
- Molecular Virology & Microbiology Retreat (11/2008)
- 1st place Post-doctoral Oral Presentation
- Molecular Virology & Microbiology Retreat (11/2009)
- Keynote Speaker for the "Celebration of Learning" Symposium
- Augustana College, Rock Island, IL (05/2009)
- mBio paper “Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity” was chosen as 2010 “Editors’ Pick”
- mBio Journal (10/2010)
- 2nd place Post-doctoral Poster Presentation
- Molecular Virology & Microbiology Retreat (12/2010)
- Awarded a Howard Hughes Medical Institute Scholarship to attend the Cold Spring Harbor Laboratory Ion Channels & Synaptic Transmission course
- Cold Spring Harbor Laboratories (06/2012)
- mBio paper “Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity” was chosen as 2010 “Hot Paper” by a postdoctoral fellow
- Molecular Virology & Microbiology Retreat (11/2011)
Professional Interests
- Enteric Virus Calcium Channel Blockers
- Exploitation of Host Calcium Signaling Pathways by Microbes
- Characterization of Viral Ion Channels (Viroporins)
- Engineering of human intestinal enteroids
Websites
Latest publications
Selected Publications
- 17. J.L. Perry, N.K. Ramachandran, B. Utama, and J.M. Hyser "Use of Genetically-encoded Calcium Indicators for Live Cell Calcium Imaging and Localization in Virus-infected Cells." Methods. 2015 Nov 15;15(90) Pubmed PMID: 26344758
- Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. "Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity." J. Virol.. 2013;87(4):13579-88. Pubmed PMID: 24109210
- 22. A.C. Strtak, J.L. Perry, M.N. Sharp, A.L. Chang-Graham, T. Farkas, J.M. Hyser "Recovirus NS1-2 has viroporin activity that induces aberrant cellular calcium signaling to facilitate virus replication." mSphere. 2019 Sep 18;4(5) Pubmed PMID: 31533997
- 21. A.L. Chang-Graham, J.L. Perry, A.C. Strtak, N.K. Ramachandran, J.M. Criglar, A.A. Philip, J.T. Patton, M.K. Estes, and J.M. Hyser "Rotavirus calcium dysregulation manifests as dynamic calcium signaling in the cytoplasm and endoplasmic reticulum." Sci Rep. 2019 Jul 25;9(1) Pubmed PMID: 31346185
- Hyser JM, Collinson-Pautz MR, Utama B, Estes MK "Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity.." MBio. 2010;1(5) Pubmed PMID: 21151776
- 33. A.L. Chang-Graham, J.L. Perry, M.A. Engevik, K.A. Engevik, F.J. Scribano, J.T. Gebert, H.A. Danhof, J.C. Nelson, J.S. Kellen, A.C. Strtak, N.P. Sastri, M.K. Estes, R.A. Britton, J. Versalovic, J.M. Hyser "Rotavirus induces intercellular calcium waves through ADP signaling." Science. 2020 Nov 20;370:eabc3621. Pubmed PMID: 33214249
Memberships
- American Society for Virology
- American Society for Microbiology
- American Physiology Society
- American Gastroenterological Association
Funding
- Regulation of Enteric Virus Secretory Diarrhea - #R03 DK110270 (04/15/2017 - 03/31/2019) Grant funding from NIH-NIDDK
- Enteric Virus Calcium Channel Blockers (09/15/2012 - 04/30/2017) NIDDK
- Career Development Award (K01)
- Calcium-induced autophagy by HIV-1 Vpu viroporin activity (08/15/2014 - 08/14/2016) Grant funding from Creative and Novel Ideas in HIV Research
- Autophagy is a cellular recycling system induced by HIV-1 through an unknown mechanism that facilitates virus replication. We propose autophagy is induced through elevation of cytoplasmic calcium triggered by Vpu viroporin-mediated release of ER calcium. We will determine how HIV induces autophagy and the role Vpu plays in calcium homeostasis.
- Enteric Virus Calcium Channel Inhibitors (02/15/2011 - 02/14/2012) Texas Medical Center Digestive Diseases Center
- Calcium Gated Viral Calcium Channels (02/15/2012 - 02/14/2013) Texas Medical Center Digestive Diseases Center
- Liposome Dye-release Viroporin Inhibitor Screen (03/23/2012 - 04/27/2012) American Society for Microbiology
- Heatley-Payne Exchange Program for Early Career Scientists. This program funded travel to the University of Leeds, UK to work with Dr. Stephen Griffin. Together we developed his viroporin dye release assay to screen for NSP4 viroporin inhibitor drugs
- Liposome Dye-release Viroporin Inhibitor Screen (01/01/2012 - 06/30/2013) Jack Carter Technology Catalyst Fund
- Research Training in Pediatric Gastroenterology - #T32 DK007664 (01/01/2009 - 12/31/2010) NIDDK
- Postdoctoral training grant (2 years of support)
- Research Training Program in Molecular Virology - #T32 AI07471 (01/01/2008 - 12/31/2008) NIAID
- Postdoctoral training grant (1 year of support)
- Enterocyte Calcium Channels in Rotavirus-mediated Activation of Chloride Secretion (07/01/2014 - 06/30/2015) Grant funding from American Gastroenterological Association
- Diarrheal diseases are a leading cause of morbidity and mortality, particularly among children under five years old in developing countries. Secretory diarrhea due to enteric virus or bacterial infections is caused by increased cyclic nucleotide or calcium signaling that causes chloride secretion by enterocytes. While the molecular mechanisms underlying cyclic nucleotide signaling have been determined using bacterial toxins, such as cholera toxin, much less is known about the mechanisms underlying calcium-induced chloride secretion in the intestine. Rotavirus is an enteric virus that exploits calcium signaling to cause diarrhea and remains a significant public health threat in developing countries. This AGA pilot award supports new research to identify the calcium channels and calcium signaling pathways responsible for activating chloride secretion from rotavirus-infected cells. By mapping the calcium signaling pathways that underlie rotavirus diarrhea, we gain insight into how better to treat infectious diarrhea diseases and potentially develop new therapeutics for next generation anti-diarrheal drugs.
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