Graeme Mardon, Ph.D.
Picture
Positions
- James R. Davis Chair in Pathology and Immunology
-
Baylor College of Medicine
Houston, Texas United States
- Professor
-
Molecular and Human Genetics
Baylor College of Medicine
- Co-Director
-
Graduate Program in Molecular and Human Genetics
Baylor College of Medicine
- Professor
-
Program in Developmental Biology
Baylor College of Medicine
- Professor
-
Neuroscience
Baylor College of Medicine
- Professor
-
Program in Integrative Molecular and Biomedical Sciences
Baylor College of Medicine
- Professor
-
Ophthalmology
Baylor College of Medicine
Education
- BS from Haverford College
- 01/1980 - Haverford, PA United States
- PhD from Massachusetts Institute Of Technology
- 01/1990 - Cambridge, MA United States
- Post-Doctoral Fellowship at University Of California, Berkeley
- 01/1994 - Berkeley, CA United States
Honors & Awards
- Best Lecturer, 8-Stranded Beta-Barrel Jelly Roll Awards, Baylor College of Medicine
- Baylor College of Medicine (01/2008)
- James M. Barr Award for Outstanding Retina Research Achievement
- 01/2006
- James M. Barr Award for Outstanding Retina Research Achievement
- 01/2002
- Marc Dresden Excellence in Graduate Education Award, Baylor College of Medicine
- Baylor College of Medicine (01/2001)
- Brochstein Award for Outstanding Achievement in Retina Research
- 01/1999
Professional Interests
- Retinal cell fate determination, development, and function in Drosophila and vertebrates
Professional Statement
The primary goal of our research is to understand the molecular mechanisms of retinal development with the ultimate goal of improving our ability to prevent, diagnose and treat human retinal disease. To this end, we are using the fruit fly Drosophila melanogaster as a model system to identify and determine the function of conserved genes required for normal retinal development. In spite of substantial differences between vertebrate and insect retinal morphology, genetic mechanisms of retinal development have been conserved for more than 500 million years. Thus, study of the molecular and genetic pathways controlling Drosophila eye development has provided a valuable set of tools with which to decipher the development and function of the vertebrate retina.Our current research begins with the observation that the Epidermal Growth Factor Receptor (Egfr, a receptor tyrosine kinase) signaling pathway is both necessary and sufficient to trigger the differentiation of nearly all cell types in the Drosophila retina. This finding posed the question of how activation of a single pathway could trigger the differentiation of more than ten different cell types in the same tissue at the same time during development. Given the fundamental importance of Egfr signaling throughout higher eukaryotes in cancer, cell differentiation, proliferation and survival, it is of broad significance to unravel this conundrum. To this end, we have generated extensive single cell RNA-sequencing data on multiple stages of the developing and adult Drosophila eye, as well single cell chromatin accessibility data (ATAC-seq), and whole eye disc ChIP-seq for Pointed, the nuclear effector of Egfr signaling. Integration and mining of these data has led to multiple hypotheses of how the Egfr pathway is reiteratively used to regulate retinal cell fate determination which we are currently testing. In addition, these data have revealed many other new insights into Drosophila eye development with unprecedented resolution and provide a fertile starting point for myriad studies.
Websites
Selected Publications
- Roman D, Zhong H, Yaklichkin S, Chen R, Mardon G "Conditional Loss of Kcnj13 in the Retinal Pigment Epithelium Causes Photoreceptor Degeneration." Exp Eye Res. 2018 Jul 25;176:219-226. Pubmed PMID: 30009826
- Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. "SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.." J Cell Biol. 2018 Aug 6;217(8):2851-2865. Pubmed PMID: 29899041
- Retshabile G, Mlotshwa BC, Williams L, Mwesigwa S, Mboowa G, Huang Z, Rustagi N, Swaminathan S, Katagirya E, Kyobe S, Wayengera M, Kisitu GP, Kateete DP, Wampande EM, Maplanka K, Kasvosve I, Pettitt ED, Matshaba M, Nsangi B, Marape M, et al "Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana.." Am J Hum Genet. 2018 May 3;102(5):731-743. Pubmed PMID: 29706352
- Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G. "Conditional knockout of retinal determination genes in differentiating cells in Drosophila.." FEBS J.. 2016 Aug;283(15):2754-66. Pubmed PMID: 27257739
- Jin M, Mardon G. "Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.." Sci Rep.. 2016 Mar 16;6(23228) Pubmed PMID: 26980695
- Zhong H, Eblimit A, Moayedi Y, Boye SL, Chiodo VA, Chen Y, Li Y, Nichols RM, Hauswirth WW, Chen R, Mardon G "AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa." Gene Ther. 2015 Aug;22:619-627. Pubmed PMID: 25965394
- Zhong H, Chen Y, Li Y, Chen R, Mardon G "CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes." Sci Rep.. 2015 Jul;5:9731. Pubmed PMID: 26177189
- Jusiak B, Wang F, Karandikar UC, Kwak SJ, Wang H, Chen R, Mardon G "Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster." Genom Data. 2014 Dec 1;2:153-5. Pubmed PMID: 25126519
- Yang Z, Zhong H, Chen J, Zhang X, Zhang H, Luo X, Xu S, Chen H, Lu D, Han Y, Li J, Fu L, Qi X, Peng Y, Xiang K, Lin Q, Guo Y, Li M, Cao X, Zhang Y, Liao S, Peng Y, Zhang L, Guo X, Dong S, Liang F, Wang J, Willden A, Seang Aun H, Serey B., et al "A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution.." Mol Biol Evol.. 2016 May;33(5):1177-87. Pubmed PMID: 26744415
- Pepple KL, Anderson AE, Frankfort BJ, Mardon G "A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin.." Genetics. 2007 Jan;175(1):125-41. Pubmed PMID: 17110483
- Gaul U, Mardon G, Rubin GM "A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase.." Cell. 1992 Mar 20;68(6):1007-19. Pubmed PMID: 1547500
- Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G "Characterization of mouse Dach2, a homologue of Drosophila dachshund.." Mech. Dev.. 2001 Apr;102(41276):169-79. Pubmed PMID: 11287190
- Loosli F, Mardon G, Wittbrodt J "Cloning and expression of medaka Dachshund.." Mech. Dev.. 2002 Mar;112(41276):203-6. Pubmed PMID: 11850196
- Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Mardon G, Chen R. "Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice.." Exp Eye Res.. 2018 Jan;166:120-130. Pubmed PMID: 29100828
- Inoue Y, Mito T, Miyawaki K, Matsushima K, Shinmyo Y, Heanue TA, Mardon G, Ohuchi H, Noji S "Correlation of expression patterns of homothorax, dachshund, and Distal-less with the proximodistal segmentation of the cricket leg bud.." Mech. Dev.. 2002 May;113(2):141-8. Pubmed PMID: 11960702
- Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Moayedi Y, Mardon G, Chen R. "Corrigendum to "Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice" [Exp. Eye Res. 166 (2018) 120-130].." Exp Eye Res.. 2018 Jun;171:119. Pubmed PMID: 29579643
- Davis RJ, Shen W, Sandler YI, Amoui M, Purcell P, Maas R, Ou CN, Vogel H, Beaudet AL, Mardon G "Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality.." Mol. Cell. Biol.. 2001 Mar;21(5):1484-90. Pubmed PMID: 11238885
- Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ "Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes.." Mech. Dev.. 2002 Feb;111(41276):75-87. Pubmed PMID: 11804780
- Chen R, Amoui M, Zhang Z, Mardon G "Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila.." Cell. 1997 Dec 26;91(7):893-903. Pubmed PMID: 9428513
- Mardon G, Solomon NM, Rubin GM "dachshund encodes a nuclear protein required for normal eye and leg development in Drosophila.." Development. 1994 Dec;120(12):3473-86. Pubmed PMID: 7821215
- Tavsanli BC, Pappu KS, Mehta SQ, Mardon G "Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity.." Genesis. 2001 Nov;31(3):130-6. Pubmed PMID: 11747204
- Karandikar UC, Jin M, Jusiak B, Kwak S, Chen R, Mardon G "Drosophila eyes absent is required for normal cone and pigment cell development." PLoS One. 2014 Jul 24;9(7):e102143. Pubmed PMID: 25057928
- Pesah Y, Pham T, Burgess H, Middlebrooks B, Verstreken P, Zhou Y, Harding M, Bellen H, Mardon G "Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.." Development. 2004 May;131(9):2183-94. Pubmed PMID: 15073152
- Davis RJ, Tavsanli BC, Dittrich C, Walldorf U, Mardon G "Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development.." Dev. Biol.. 2003 Jul 15;259(2):272-87. Pubmed PMID: 12871701
- Haase Gilbert E, Kwak SJ, Chen R, Mardon G "Drosophila signal peptidase complex member spase12 is required for development and cell differentiation.." PLoS ONE. 2013;8(4):e60908. Pubmed PMID: 23573290
- Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G "Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund.." Development. 2005 Jun;132(12):2895-905. Pubmed PMID: 15930118
- Mardon G, Mosher R, Disteche CM, Nishioka Y, McLaren A, Page DC "Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome.." Science. 1989 Jan 6;243(4887):78-80. Pubmed PMID: 2563173
- Atkins M, Jiang Y, Sansores-Garcia L, Jusiak B, Halder G, Mardon G "Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.." PLoS Genet.. 2013;9(8):e1003731. Pubmed PMID: 24009524
- Shen W, Mardon G "Ectopic eye development in Drosophila induced by directed dachshund expression.." Development. 1997 Jan;124(1):45-52. Pubmed PMID: 9006066
- Zhong H, Chen Y, Li Y, Chen R, Mardon G. "Erratum: CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes.." Sci Rep. 2015 Jul 15;5:9731. Pubmed PMID: 26177189
- Wang H, Chen X, Dudinsky L, Patenia C, Chen Y, Li Y, Wei Y, Abboud EB, Al-Rajhi AA, Lewis RA, Lupski JR, Mardon G, Gibbs RA, Perkins BD, Chen R "Exome capture sequencing identifies a novel mutation in BBS4.." Mol. Vis.. 2011;17:3529-40. Pubmed PMID: 22219648
- Rayapureddi JP, Kattamuri C, Steinmetz BD, Frankfort BJ, Ostrin EJ, Mardon G, Hegde RS "Eyes absent represents a class of protein tyrosine phosphatases.." Nature. 2003 Nov 20;426(6964):295-8. Pubmed PMID: 14628052
- Jin M, Jusiak B, Bai Z, Mardon G "Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival.." PLoS ONE. 2013;8(3):e58818. Pubmed PMID: 23554934
- Mardon G, Varmus HE "Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins.." Cell. 1983 Mar;32(3):871-9. Pubmed PMID: 6299579
- Pappu KS, Mardon G "Genetic control of retinal specification and determination in Drosophila.." Int. J. Dev. Biol.. 2004;48(41495):913-24. Pubmed PMID: 15558482
- Ostrin EJ, Li Y, Hoffman K, Liu J, Wang K, Zhang L, Mardon G, Chen R "Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless.." Genome Res.. 2006 Apr;16(4):466-76. Pubmed PMID: 16533912
- Jin M, Aibar S, Ge Z, Chen R, Aerts S, Mardon G. "Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.." Dev Biol.. 2016 Jul 1;415(1):157-67. Pubmed PMID: 27178668
- Schaeffer E, Smith D, Mardon G, Quinn W, Zuker C "Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells.." Cell. 1989 May 5;57(3):403-12. Pubmed PMID: 2720775
- Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM "Isolation of duplicated human c-src genes located on chromosomes 1 and 20.." Mol. Cell. Biol.. 1985 Apr;5(4):831-8. Pubmed PMID: 2581127
- Chen R, Mardon G "Keeping an eye on the fly genome.." Dev. Biol.. 2005 Jun 15;282(2):285-93. Pubmed PMID: 15893305
- Jusiak B, Abulimiti A, Haelterman N, Chen R, Mardon G "MAPK target sites of eyes absent are not required for eye development or survival in Drosophila.." PLoS ONE. 2012;7(12):e50776. Pubmed PMID: 23251383
- Pappu KS, Chen R, Middlebrooks BW, Woo C, Heberlein U, Mardon G "Mechanism of hedgehog signaling during Drosophila eye development.." Development. 2003 Jul;130(13):3053-62. Pubmed PMID: 12756186
- Davis RJ, Shen W, Heanue TA, Mardon G "Mouse Dach, a homologue of Drosophila dachshund, is expressed in the developing retina, brain and limbs.." Dev. Genes Evol.. 1999 Sep;209(9):526-36. Pubmed PMID: 10502109
- Davis RJ, Harding M, Moayedi Y, Mardon G "Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development.." Genesis. 2008 Apr;46(4):205-13. Pubmed PMID: 18395837
- Davis RJ, Pesah YI, Harding M, Paylor R, Mardon G "Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function.." Genesis. 2006 Feb;44(2):84-92. Pubmed PMID: 16470613
- Mardon G, Luoh SW, Simpson EM, Gill G, Brown LG, Page DC "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.." Mol. Cell. Biol.. 1990 Feb;10(2):681-8. Pubmed PMID: 2105457
- Li Y, Wang H, Peng J, Gibbs RA, Lewis RA, Lupski JR, Mardon G, Chen R "Mutation survey of known LCA genes and loci in the Saudi Arabian population.." Invest. Ophthalmol. Vis. Sci.. 2009 Mar;50(3):1336-43. Pubmed PMID: 18936139
- Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Nageeb M "Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration.." Nat. Genet.. 2012 Jul 29;44(9):1035-9. Pubmed PMID: 22842230
- Wang H, den Hollander AI, Moayedi Y, Abulimiti A, Li Y, Collin RW, Hoyng CB, Lopez I, Abboud EB, Al-Rajhi AA, Bray M, Lewis RA, Lupski JR, Mardon G, Koenekoop RK, Chen R "Mutations in SPATA7 cause Leber congenital amaurosis and juvenile retinitis pigmentosa.." Am. J. Hum. Genet.. 2009 Mar;84(3):380-7. Pubmed PMID: 19268277
- Eblimit A, Zaneveld SA, Liu W, Thomas K, Wang K, Li Y, Mardon G, Chen R. "NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype.." Exp Eye Res.. 2018 Aug;173:32-43. Pubmed PMID: 29674119
- Li Y, Jiang Y, Chen Y, Karandikar U, Hoffman K, Chattopadhyay A, Mardon G, Chen R. "optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila.." Dev Biol.. 2013 Sep 1;381(1):50-61. Pubmed PMID: 23792115
- Purcell P, Oliver G, Mardon G, Donner AL, Maas RL "Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction.." Gene Expr. Patterns. 2005 Dec;6(1):110-8. Pubmed PMID: 16024294
- Wiszniewski W, Lewis RA, Stockton DW, Peng J, Mardon G, Chen R, Lupski JR "Potential involvement of more than one locus in trait manifestation for individuals with Leber congenital amaurosis.." Hum. Genet.. 2011 Mar;129(3):319-27. Pubmed PMID: 21153841
- McClard CK, Kochukov MY, Herman I, Liu Z, Eblimit A, Moayedi Y, Ortiz-Guzman J, Colchado D, Pekarek B, Panneerselvam S, Mardon G, Arenkiel BR. "POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.." J Neurosci.. 2018 Feb 7;38(6):1443-1461. Pubmed PMID: 29305536
- Schneider-Gädicke A, Beer-Romero P, Brown LG, Mardon G, Luoh SW, Page DC "Putative transcription activator with alternative isoforms encoded by human ZFX gene.." Nature. 1989 Dec 7;342(6250):708-11. Pubmed PMID: 2512506
- Iyer J, Wang Q, Le T, Pizzo L, Grönke S, Ambegaokar SS, Imai Y, Srivastava A, Troisí BL, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Lu B, Kumar JP, Girirajan S. "Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.." G3 (Bethesda). 2016 May 3;6(5):1427-37. Pubmed PMID: 26994292
- Frankfort BJ, Mardon G "R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.." Development. 2002 Mar;129(6):1295-306. Pubmed PMID: 11880339
- Jusiak B, Karandikar UC, Kwak SJ, Wang F, Wang H, Chen R, Mardon G "Regulation of Drosophila eye development by the transcription factor Sine oculis." PLoS One. 2014 Feb 25;9(2):e89695. Pubmed PMID: 24586968
- Domingos PM, Brown S, Barrio R, Ratnakumar K, Frankfort BJ, Mardon G, Steller H, Mollereau B "Regulation of R7 and R8 differentiation by the spalt genes.." Dev. Biol.. 2004 Sep 1;273(1):121-33. Pubmed PMID: 15302602
- H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, et al "Research capacity. Enabling the genomic revolution in Africa.." Science. 2014 Jun 20;344(6190):1346-8. Pubmed PMID: 24948725
- Pappu KS, Mardon G. "Retinal specification and determination in Drosophila.." Int J Dev Biol. 2004;48(8-9):913-24. Pubmed PMID: 15558482
- Jiang Y, Scott KL, Kwak SJ, Chen R, Mardon G "Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.." Oncogene. 2011 Jul 21;30(29):3248-60. Pubmed PMID: 21399659
- Frankfort BJ, Pepple KL, Mamlouk M, Rose MF, Mardon G "Senseless is required for pupal retinal development in Drosophila.." Genesis. 2004 Apr;38(4):182-94. Pubmed PMID: 15083519
- Frankfort BJ, Mardon G "Senseless represses nuclear transduction of Egfr pathway activation.." Development. 2004 Feb;131(3):563-70. Pubmed PMID: 14711872
- Frankfort BJ, Nolo R, Zhang Z, Bellen H, Mardon G "senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye.." Neuron. 2001 Nov 8;32(3):403-14. Pubmed PMID: 11709152
- Simon MA, Carthew RW, Fortini ME, Gaul U, Mardon G, Rubin GM "Signal transduction pathway initiated by activation of the sevenless tyrosine kinase receptor.." Cold Spring Harb. Symp. Quant. Biol.. 1992;57:375-80. Pubmed PMID: 1339672
- Chen R, Halder G, Zhang Z, Mardon G "Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila.." Development. 1999 Feb;126(5):935-43. Pubmed PMID: 9927595
- Atkins M, Mardon G "Signaling in the third dimension: the peripodial epithelium in eye disc development.." Dev. Dyn.. 2009 Sep;238(9):2139-48. Pubmed PMID: 19623613
- Eblimit A, Nguyen TM, Chen Y, Esteve-Rudd J, Zhong H, Letteboer S, Van Reeuwijk J, Simons DL, Ding Q, Wu KM, Li Y, Van Beersum S, Moayedi Y, Xu H, Pickard P, Wang K, Gan L, Wu SM, Williams DS, Mardon G, Roepman R, Chen R. "Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina.." Hum Mol Genet. 2015 Mar 15;24(6):1584-601. Pubmed PMID: 25398945
- Tavsanli BC, Ostrin EJ, Burgess HK, Middlebrooks BW, Pham TA, Mardon G "Structure-function analysis of the Drosophila retinal determination protein Dachshund.." Dev. Biol.. 2004 Aug 1;272(1):231-47. Pubmed PMID: 15242803
- Heanue TA, Reshef R, Davis RJ, Mardon G, Oliver G, Tomarev S, Lassar AB, Tabin CJ "Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.." Genes Dev.. 1999 Dec 15;13(24):3231-43. Pubmed PMID: 10617572
- Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK. "The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.." PLoS Genet. 2014 Jan;10(1):e1004055. Pubmed PMID: 24391519
- Mlotshwa BC, Mwesigwa S, Mboowa G, Williams L, Retshabile G, Kekitiinwa A, Wayengera M, Kyobe S, Brown CW, Hanchard NA, Mardon G, Joloba M, Anabwani G, Mpoloka SW. "The collaborative African genomics network training program: a trainee perspective on training the next generation of African scientists.." Genet Med. 2017 Jul;19(7):826-833. Pubmed PMID: 28383545
- Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG "The Dachshund gene in development and hormone-responsive tumorigenesis.." Trends Endocrinol. Metab.. 2010 Jan;21(1):41-9. Pubmed PMID: 19896866
- Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG. "The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.." Cancer Res. 2015 May 15;75(10):1992-2004. Pubmed PMID: 25769723
- Anderson AE, Karandikar UC, Pepple KL, Chen Z, Bergmann A, Mardon G "The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.." Development. 2011 May;138(10):1957-66. Pubmed PMID: 21490066
- Kaplan JM, Mardon G, Bishop JM, Varmus HE "The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant.." Mol. Cell. Biol.. 1988 Jun;8(6):2435-41. Pubmed PMID: 2841581
- "The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis." ; Pubmed PMID: 30022023
- Martini SR, Roman G, Meuser S, Mardon G, Davis RL "The retinal determination gene, dachshund, is required for mushroom body cell differentiation.." Development. 2000 Jun;127(12):2663-72. Pubmed PMID: 10821764
- Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG "The sex-determining region of the human Y chromosome encodes a finger protein.." Cell. 1987 Dec 24;51(6):1091-104. Pubmed PMID: 3690661
- Mardon G, Page DC "The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers.." Cell. 1989 Mar 10;56(5):765-70. Pubmed PMID: 2493989
- Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon G "Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.." Development. 2008 Dec;135(24):4071-9. Pubmed PMID: 19004852
- Wang X, Wang H, Cao M, Li Z, Chen X, Patenia C, Gore A, Abboud EB, Al-Rajhi AA, A Lewis R, Lupski JR, Mardon G, Zhang K, Muzny D, Gibbs RA, Chen R "Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis.." Hum. Mutat.. 2011 Dec;32(12):1450-9. Pubmed PMID: 21901789
- Pesah Y, Burgess H, Middlebrooks B, Ronningen K, Prosser J, Tirunagaru V, Zysk J, Mardon G "Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila.." Genesis. 2005 Apr;41(4):154-9. Pubmed PMID: 15789427
- Yeung K, Wang F, Li Y, Wang K, Mardon G, Chen R "Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.." Nucleic Acids Res.. 2018;46:11743-11758.
Log In to edit your profile
