Isamu Aiba, Ph.D.
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Isamu Aiba, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Neurology
Baylor College of Medicine
Houston, Texas
Addresses
- Department of Neurology (Office)
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Baylor College of Medicine
One Baylor Plaza, MS NA200
Houston, TX 77030
United States
Education
- PhD from University of New Mexico
- Albuquerque, New Mexico United States
Professional Interests
- Spreading depolarization
- Epilepsy
- Sudden Unexpected Death in Epilepsy
- Autonomic Dysfunction
Websites
Comprehensive list of publications and presentations
Selected Publications
- Aiba I, Wehrens XH, Noebels JL. "Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.." Proc Natl Acad Sci U S A.. 2016 Aug; Pubmed PMID: 27482086
- Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL. "Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy.." J Neurosci.. 2016 Jan; Pubmed PMID: 26758833
- Aiba I, Noebels JL. "Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models.." Sci Transl Med.. 2015 Apr; Pubmed PMID: 25855492
- Aiba I, Shuttleworth CW. "Characterization of inhibitory GABA-A receptor activation during spreading depolarization in brain slice.." PLoS One. 2014 Oct; Pubmed PMID: 25338191
- Aiba I, West AK, Sheline CT, Shuttleworth CW. "Intracellular dialysis disrupts Zn2+ dynamics and enables selective detection of Zn2+ influx in brain slice preparations.." J Neurochem.. 2013 Jun; Pubmed PMID: 23517525
- Seidel JL, Faideau M, Aiba I, Pannasch U, Escartin C, Rouach N, Bonvento G, Shuttleworth CW. "Ciliary neurotrophic factor (CNTF) activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance.." Glia. 2015 Jan; Pubmed PMID: 25092804
- Aiba I, Shuttleworth CW. "Sustained NMDA receptor activation by spreading depolarizations can initiate excitotoxic injury in metabolically compromised neurons.." J Physiol.. 2012 Nov; Pubmed PMID: 22907056
- Aiba I, Carlson AP, Sheline CT, Shuttleworth CW. "Synaptic release and extracellular actions of Zn2+ limit propagation of spreading depression and related events in vitro and in vivo.." J Neurophysiol.. 2012 Feb; Pubmed PMID: 22131381
- Aiba I, Yamasaki T, Shinki T, Izumi S, Yamamoto K, Yamada S, Terato H, Ide H, Ohyama Y "Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases." Steroids. 2006 Oct; Pubmed PMID: 16842832
- Aiba I, Hossain A, Kuo MT. "Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8.." Mol Pharmacol.. 2008 Sep; Pubmed PMID: 18556457
- Tsai WB, Aiba I, Lee SY, Feun L, Savaraj N, Kuo MT. "Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.." Mol Cancer Ther.. 2009 Dec; Pubmed PMID: 19934275
- Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N, Kuo MT. "Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells.." Cancer Res.. 2012 May; Pubmed PMID: 22461507
- Chen HH, Chen WC, Liang ZD, Tsai WB, Long Y, Aiba I, Fu S, Broaddus R, Liu J, Feun LG, Savaraj N, Kuo MT. "Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.." Expert Opin Ther Targets.. 2015; Pubmed PMID: 26004625
- Carter RE, Aiba I, Dietz RM, Sheline CT, Shuttleworth CW. "Spreading depression and related events are significant sources of neuronal Zn2+ release and accumulation.." J Cereb Blood Flow Metab. 2011 Apr; Pubmed PMID: 20978516
- Durnin L, Dai Y, Aiba I, Shuttleworth CW, Yamboliev IA, Mutafova-Yambolieva VN. "Release, neuronal effects and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD⁺) in the rat brain.." Eur J Neurosci.. 2012 Feb; Pubmed PMID: 22276961
- Aiba I, Shuttleworth CW. "Hypoxia limits inhibitory effects of Zn2+ on spreading depolarizations.." PLoS One. 2013 Nov; Pubmed PMID: 24278106
- Song IS, Chen HH, Aiba I, Hossain A, Liang ZD, Klomp LW, Kuo MT "Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells.." Mol Pharmacol.. 2008 Sep; Pubmed PMID: 18483225
- Isamu Aiba and Jeffrey Noebels "Adrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability." Journal of neurophysiology. 2019;
- Aiba I, Noebels JL "Kcnq2/Kv7.2 controls the threshold and bi-hemispheric symmetry of cortical spreading depolarization." Brain. 2021 Oct 22;
- Hatcher A, Yu K, Meyer J, Aiba I, Deneen B, Noebels JL. "Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model.." J Clin Invest. 2020 May 1;
Funding
- Career Development Award Grant funding from American Heart Association
- Junior Investigator Research Award (07/01/2021 - 06/30/2022) Grant funding from American Epilepsy Society
Languages
Japanese
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