Email

noah.shroyer@bcm.edu

Positions

Associate Professor

Department of Medicine Section of Gastroenterology and Hepatology
Baylor College of Medicine
Houston, Texas

Adjunct Associate Professor

Department of Pediatrics Division of Gastroenterology, Hepatology & Nutrition Cincinnati Children's Hospital
University of Cincinnati
Cincinnati, Ohio

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Core Director

Digestive Diseases Center
Texas Medical Center

https://www.bcm.edu/research/centers/digestive-disease

Addresses

BCM-Alkek Graduate School (Lab)

Room: BCMN-N1301
Houston, TX 77030
United States

Education

BS from Louisiana State University

Baton Rouge, Louisiana United States

Microbiology and Biochemistry

PhD from Baylor College of Medicine

Houston, Texas United States

Cell and Molecular Biology

Post-Doctoral Fellowship at Baylor College of Medicine

Houston, Texas United States

Molecular and Human Genetics

Professional Interests

• Mechanisms that control intestinal development and homeostasis
• Human Enteroids

Professional Statement

My laboratory is focused on understanding the mechanisms that control intestinal development and homeostasis, and translating this knowledge into novel therapeutic approaches to treat diseases of the intestine such as IBD and colorectal cancer. My laboratory has elucidated roles for epithelial transcription factors such as Atoh1 (Math1), Gfi1, and Spdef in development and differentiation of the intestine. Moreover, my laboratory has translated these findings to human diseases, by showing that Atoh1 and its target Spdef are tumor suppressors that are frequently silenced in colon cancers, and that these genes are essential targets of Notch inhibitory drugs. In addition to these mechanistic studies, we have recently developed novel organ culture methods to direct differentiation of human pluripotent stem cells into intestinal tissue to study intestinal development and disease, and we have used intestinal stem cell-derived organoids in quantitative assays to evaluate intestinal stem cell activity.

Websites

Selected Publications

• Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. "Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.." 2011 Feb; Pubmed PMID: 21151107
• Noah TK, Shroyer NF. "Notch in the intestine: regulation of homeostasis and pathogenesis.." 2013; Pubmed PMID: 23190077
• Lo Y-H., Chung, E., Li, Z., Wan, Y-W., Mahe, M.M., Chen, M-S., Noah, T.K., Bell, K.N., Yalamanchili, H.K., Klisch, T.J., Liu, Z., Park, J-S., Shroyer, N.F. "Transcriptional regulation by ATOH1 and its target SPDEF in the intestine.." Cellular and Molecular Gastroenterology and Hepatology.. 2017;3:51-71. Pubmed PMID: 28174757
• Lo Y-H., Noah, T.K., Chen, M-S., Zou, W., Borras, E., Vilar, E., Shroyer, N.F. "SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin." Gastroenterology. 2017;153:205-218. Pubmed PMID: 28390865