Angela M Yu, Ph.D.

Assistant Professor

Email

angela.yu@bcm.edu

Positions

Assistant Professor: Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas, United States

Core Member: Therapeutic Innovation Center
Baylor College of Medicine
Houston, Texas, United States

Faculty Member: Chemical, Physical & Structural Biology Graduate Program
Baylor College of Medicine
Houston, Texas, United States

Faculty Member: Quantitative & Computational Biosciences Graduate Program
Baylor College of Medicine
Houston, Texas, United States

Education

BAS from University of Pennsylvania: 05/2014 - Philadelphia, Pennsylvania, United States; Computational Biology

PhD from Weill Cornell Medicine: 05/2020 - New York, New York, United States; Tri-Institutional Training Program in Computational Biology and Medicine

Postdoctoral Fellowship at University of Washington: Seattle, Washington, United States

Honors & Awards

Washington Research Foundation Postdoctoral Fellow: (01/2021 - 12/2023)

Honorable Mention, NSF Graduate Research Fellowships Program (GRFP), Life Sciences – Bioinformatics and Computational Biology, 2016

Professional Statement

The Yu Lab's mission is to better understand dynamical RNA regulation in human health applications and develop therapeutics based on this knowledge. To achieve our goals, we will leverage techniques spanning artificial intelligence (AI), computational biology, bioinformatics, and bioengineering. We are particularly engaged in studying RNAs during their synthesis to reveal insights into their regulation and structure that may be used in disease treatments.

Websites

Yu Lab

Google Scholar

Selected Publications

Angela M Yu, Paul M. Gasper, Luyi Cheng, Lien B. Lai, Simi Kaur, Venkat Gopalan, Alan A. Chen, and Julius B. Lucks. " Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates " Molecular Cell. 2021 Feb 18; 81 (4) : 870-883. e10.
Pubmed PMID: 33453165.
Liang Liu*, Angela M Yu*, et al.. " The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery " Nature Structural & Molecular Biology. 2023 Dec ; 30 (12) : 1947-1957.
Pubmed PMID: 38087090.
Albert Y Xue*, Angela M Yu*, Julius B Lucks, Neda Bagheri. " DUETT quantitatively identifies known and novel events in nascent RNA structural dynamics from chemical probing data " Bioinformatics. 2019 Dec 15; 35 (24) : 5103-5112.
Pubmed PMID: 31389563.
Kyle E Watters, Eric J Strobel, Angela M Yu, John T Lis, Julius B Lucks. " Cotranscriptional folding of a riboswitch at nucleotide resolution " Nature Structural & Molecular Biology. 2016 Dec ; 23 (12) : 1124-1131.
Pubmed PMID: 27798597.